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Full-Text Articles in Medicine and Health Sciences
Hearing Studies In Old Mice: The Effect Of Pre-Pulse Inhibition On The Acoustic Startle Response, Ashley B. Hillyard, Nicolette S. Chuss
Hearing Studies In Old Mice: The Effect Of Pre-Pulse Inhibition On The Acoustic Startle Response, Ashley B. Hillyard, Nicolette S. Chuss
Senior Honors Projects, 2010-2019
The purpose of this study pertains to hearing in the species Peromyscus maniculatus (deer mice) — specifically their responses to a startling sound. Approximately seven mice were tested between four and five years of age, approaching the lifespan of this species. By means of an accelerometer, which measures a reflexive, motor response, the mice were presented with an acoustic startle-eliciting stimulus (SES) — that is a loud, startling, unexpected sound. During the study, the mice were also presented with a softer, less-intense stimulus — known as a pre-pulse — slightly before the more intense sound. This pre-pulse stimulus was in …
Effect Of Age On Abrs In Mice With Epha4 Mutations, Melissa M. Teller
Effect Of Age On Abrs In Mice With Epha4 Mutations, Melissa M. Teller
Dissertations, 2014-2019
It is known that EphA4 can influence the establishment of tonotopic pathways in the auditory system. This can be measured by an increase in thresholds on the auditory brainstem response test (ABR) in mice. It is also known that the aging population in humans tends to have poorer thresholds in the high frequency sounds as they age, termed presbycusis or age-related hearing loss. The C57BL/6J background strain of mice that is known to experience a presbycusis-like process, although it is not specified when this process begins and how it progresses through their life span. The goal of this study was …
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice, Kathryn C. Brooks
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice, Kathryn C. Brooks
Senior Honors Projects, 2010-2019
The purpose of my Honors Research Project was to assist Dr. Megan
Klingenberg in completing part of the research in her final dissertation project. Dr.
Klingenberg’s project was based off of a study done by Allen and Ison in 2010.
This study tested the auditory spatial acuity of mice using pre-pulse inhibition of
the startle reflex as the response for detecting the sound stimulus. The goal of
Dr. Klingenberg’s AuD project was “to explore the methodological, functional, and
genetic influences on sound localization using pre-pulse inhibition of the acoustic
startle response in mice”. Dr. Klingenberg’s project was broken into three …
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice: Methodological, Functional, And Genetic Considerations, Megan Klingenberg
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice: Methodological, Functional, And Genetic Considerations, Megan Klingenberg
Dissertations, 2014-2019
Sound localization is an important aspect of normal hearing. The Eph/ephin family of signaling proteins, studied here, is known to guide the formation of central auditory connections in early development, particularly topographic inputs from the lateral superior olive (LSO) to the inferior colliculus (IC). Processing in the LSO and its influences on the IC are known to be heavily involved in sound localization tasks. One way to study sound localization in mice is through pre-pulse inhibition (PPI). PPI is the phenomenon by which a weak prestimulus inhibits the response to a subsequent startle stimulus. In studying sound localization, the prestimulus …
Effects Of Eph/Ephrin Mutations On Pre Pulse Inhibition In Mice, Andrea Marie Liuzzo
Effects Of Eph/Ephrin Mutations On Pre Pulse Inhibition In Mice, Andrea Marie Liuzzo
Dissertations, 2014-2019
The acoustic startle response (ASR) is a reliable reflexive behavioral response in mammals elicited by an unexpected intense acoustic startle eliciting stimulus (SES). It is mediated by a sub-cortical pathway that includes the inferior colliculus (IC). The ASR amplitude can be measured with an accelerometer beneath the subject attached to the cage, and can be decreased in amplitude by presenting a less intense, non-startling stimulus 20-300 ms before the SES. This reflexive decrement in ASR is called pre pulse inhibition (PPI) and indicates that the relatively soft pre pulse was heard. Murine species have been used to study this response …