Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Meta-analysis

2023

Discipline
Institution
Publication
Publication Type

Articles 1 - 20 of 20

Full-Text Articles in Medicine and Health Sciences

Large Multi-Ethnic Genetic Analyses Of Amyloid Imaging Identify New Genes For Alzheimer Disease, Muhammad Ali, Derek B. Archer, Priyanka Gorijala, Daniel Western, Jigyasha Timsina, Maria V. Fernández, Ting Chen Wang, Claudia L. Satizabal, Qiong Yang, Alexa S. Beiser, Ruiqi Wang, Gengsheng Chen, Brian Gordon, Tammie L.S. Benzinger, Chengjie Xiong, John C. Morris, Randall J. Bateman, Celeste M. Karch, Eric Mcdade, Alison Goate, Sudha Seshadri, Richard P. Mayeux, Reisa A. Sperling, Rachel F. Buckley, Keith A. Johnson, Hong-Hee Won, Sang-Hyuk Jung, Hang-Rai Kim, Sang W. Seo, Hee J. Kim, Elizabeth Mormino, Simon M. Laws, Kang-Hsien Fan, M. Ilyas Kamboh, Prashanthi Vemuri, Vijay K. Ramanan, Hyun-Sik Yang, Allen Wenzel, Hema S. R. Rajula, Aniket Mishra, Carole Dufouil, Stephanie Debette, Oscar L. Lopez, Steven T. Dekosky, Feifei Tao, Michael W. Nagle, Timothy J. Hohman, Yun J. Sung, Logan Dumitrescu, Carlos Cruchaga, Knight Alzheimer Disease Research Center (Knight Adrc), The Dominantly Inherited Alzheimer Network (Dian), Alzheimer's Disease Neuroimaging Initiative (Adni), Adni-Dod, A4 Study Team, The Australian Imaging Biomarkers, Lifestyle (Aibl) Study Dec 2023

Large Multi-Ethnic Genetic Analyses Of Amyloid Imaging Identify New Genes For Alzheimer Disease, Muhammad Ali, Derek B. Archer, Priyanka Gorijala, Daniel Western, Jigyasha Timsina, Maria V. Fernández, Ting Chen Wang, Claudia L. Satizabal, Qiong Yang, Alexa S. Beiser, Ruiqi Wang, Gengsheng Chen, Brian Gordon, Tammie L.S. Benzinger, Chengjie Xiong, John C. Morris, Randall J. Bateman, Celeste M. Karch, Eric Mcdade, Alison Goate, Sudha Seshadri, Richard P. Mayeux, Reisa A. Sperling, Rachel F. Buckley, Keith A. Johnson, Hong-Hee Won, Sang-Hyuk Jung, Hang-Rai Kim, Sang W. Seo, Hee J. Kim, Elizabeth Mormino, Simon M. Laws, Kang-Hsien Fan, M. Ilyas Kamboh, Prashanthi Vemuri, Vijay K. Ramanan, Hyun-Sik Yang, Allen Wenzel, Hema S. R. Rajula, Aniket Mishra, Carole Dufouil, Stephanie Debette, Oscar L. Lopez, Steven T. Dekosky, Feifei Tao, Michael W. Nagle, Timothy J. Hohman, Yun J. Sung, Logan Dumitrescu, Carlos Cruchaga, Knight Alzheimer Disease Research Center (Knight Adrc), The Dominantly Inherited Alzheimer Network (Dian), Alzheimer's Disease Neuroimaging Initiative (Adni), Adni-Dod, A4 Study Team, The Australian Imaging Biomarkers, Lifestyle (Aibl) Study

Research outputs 2022 to 2026

Amyloid PET imaging has been crucial for detecting the accumulation of amyloid beta (AB) deposits in the brain and to study Alzheimer’s disease (AD). We performed a genome-wide association study on the largest collection of amyloid imaging data (N = 13,409) to date, across multiple ethnicities from multicenter cohorts to identify variants associated with brain amyloidosis and AD risk. We found a strong APOE signal on chr19q.13.32 (top SNP: APOE 4; rs429358; = 0.35, SE = 0.01, P = 6.2 × 10–311, MAF = 0.19), driven by APOE 4, and five additional novel associations (APOE 2/rs7412; rs73052335/rs5117, rs1081105, …


Endovascular Embolization For Epistaxis: A Single Center Experience And Meta-Analysis, Kareem El Naamani, Charles Morse, Marc Ghanem, Julie Barbera, Abdelaziz Amllay, Grace Severance, Ramon Ruiz, Ahmad Sweid, Michael Gooch, Nabeel Herial, Pascal Jabbour, Robert Rosenwasswer, Gurston Nyquist, Stavropoula Tjoumakaris Nov 2023

Endovascular Embolization For Epistaxis: A Single Center Experience And Meta-Analysis, Kareem El Naamani, Charles Morse, Marc Ghanem, Julie Barbera, Abdelaziz Amllay, Grace Severance, Ramon Ruiz, Ahmad Sweid, Michael Gooch, Nabeel Herial, Pascal Jabbour, Robert Rosenwasswer, Gurston Nyquist, Stavropoula Tjoumakaris

Department of Neurosurgery Faculty Papers

The optimal treatment for intractable epistaxis is still controversial. Various studies have demonstrated high success rates and low complication rates for endovascular embolization. Herein, the authors report an institutional experience and meta-analysis in terms of efficacy and safety of endovascular embolization of intractable epistaxis. This was a retrospective observational study of 35 patients with epistaxis who underwent 40 embolization procedures between 2010 and 2023. The primary outcome was immediate success defined by immediate cessation of epistaxis at the end of the procedure. Immediate success was achieved in most of the procedures (39, 97.5%). During follow-up, three (7.5%) patients experienced a …


Spontaneous Collapse As A Prognostic Marker For Human Blastocysts: A Systematic Review And Meta-Analysis, Kate Bickendorf, Fang Qi, Kelli Peirce, Jay Natalwala, Vincent Chapple, Yanhe Liu Oct 2023

Spontaneous Collapse As A Prognostic Marker For Human Blastocysts: A Systematic Review And Meta-Analysis, Kate Bickendorf, Fang Qi, Kelli Peirce, Jay Natalwala, Vincent Chapple, Yanhe Liu

Research outputs 2022 to 2026

STUDY QUESTION: Is spontaneous collapse (SC) by human blastocysts a prognostic factor in IVF treatment? SUMMARY ANSWER: SC in human blastocyst is associated with reduced euploid embryo and pregnancy rates. WHAT IS KNOWN ALREADY: SC of the human blastocyst is a phenomenon that was revealed relatively recently following the clinical application of time-lapse monitoring in IVF laboratories. The ploidy and clinical prognosis of affected blastocysts are still poorly understood, with inconsistent reports. Systematic reviews and meta-analyses on this topic are currently absent in the literature but its potential as a marker of embryo viability holds great clinical value. In this …


Group 4 Iti Consensus Report: Patient Benefits Following Implant Treatment In Partially And Fully Edentulous Patients., Martin Schimmel, Mauricio Araujo, Samir Abou-Ayash, Ramona Buser, Supriya Ebenezer, Manrique Fonseca, Lisa J. Heitz-Mayfield, Lucrezia Paterno Holtzman, Porawit Kamnoedboon, Robert Levine, Gerry Mckenna, Sabrina Maniewicz, Flavia Matarazzo, Nikos Mattheos, Panos Papaspyridakos, André Barbisan De Souza, Murali Srinivasan, Charlotte Stilwell, Hans Peter Weber Sep 2023

Group 4 Iti Consensus Report: Patient Benefits Following Implant Treatment In Partially And Fully Edentulous Patients., Martin Schimmel, Mauricio Araujo, Samir Abou-Ayash, Ramona Buser, Supriya Ebenezer, Manrique Fonseca, Lisa J. Heitz-Mayfield, Lucrezia Paterno Holtzman, Porawit Kamnoedboon, Robert Levine, Gerry Mckenna, Sabrina Maniewicz, Flavia Matarazzo, Nikos Mattheos, Panos Papaspyridakos, André Barbisan De Souza, Murali Srinivasan, Charlotte Stilwell, Hans Peter Weber

HPD Articles

OBJECTIVES: The aim of Working Group 4 was to address patient benefits associated with implant dentistry. Focused questions on (a) dental patient-reported outcomes (dPROs), (b) improvement in orofacial function, and (c) preservation of orofacial tissues in partially and fully edentulous patients following provision of implant-retained/supported dental prostheses were addressed.

MATERIALS AND METHODS: Three systematic reviews formed the basis for discussion. Participants developed statements and recommendations determined by group consensus based on the findings of the systematic reviews. These were then presented and accepted following further discussion and modifications as required by the plenary of the 7th ITI Consensus Conference, taking …


Surgical Stabilization Of Multiple Rib Fractures In An Asian Population: A Systematic Review And Meta-Analysis, Weiwei He, Yi Yang, Raymark Salonga, Ledford Powell, Patrick Greiffenstein, Jonne T.H. Prins, Stephen Patrick Abella Sep 2023

Surgical Stabilization Of Multiple Rib Fractures In An Asian Population: A Systematic Review And Meta-Analysis, Weiwei He, Yi Yang, Raymark Salonga, Ledford Powell, Patrick Greiffenstein, Jonne T.H. Prins, Stephen Patrick Abella

School of Medicine Faculty Publications

Background: There is no consensus on the effectiveness of surgical stabilization in multiple rib fractures in Asia, especially among patients with a non-flail rib fracture pattern. We aim to synthesize the evidence on the effectiveness of surgical stabilization of rib fractures (SSRF) in an Asian population with multiple nonflail rib fractures. Methods: The MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Cochrane Database of Systematic Reviews were searched in this systematic literature review and meta-analysis to identify studies conducted in Asia that included patients with multiple non-flail rib fractures in at least one of their treatment groups. The …


The Predictive Validity Of Individualised Load–Velocity Relationships For Predicting 1rm: A Systematic Review And Individual Participant Data Meta-Analysis, Leon Greig, Rodrigo R. Aspe, Andy Hall, Paul Comfort, Kay Cooper, Paul A. Swinton Sep 2023

The Predictive Validity Of Individualised Load–Velocity Relationships For Predicting 1rm: A Systematic Review And Individual Participant Data Meta-Analysis, Leon Greig, Rodrigo R. Aspe, Andy Hall, Paul Comfort, Kay Cooper, Paul A. Swinton

Research outputs 2022 to 2026

Background: Load–velocity relationships are commonly used to estimate one-repetition maximums (1RMs). Proponents suggest these estimates can be obtained at high frequencies and assist with manipulating loads according to session-by-session fluctuations. Given their increasing popularity and development of associated technologies, a range of load–velocity approaches have been investigated. Objective: This systematic review and individual participant data (IPD) meta-analysis sought to quantify the predictive validity of individualised load–velocity relationships for the purposes of 1RM prediction. Methods: In September 2022, a search of MEDLINE, SPORTDiscus, Web of Science and Scopus was conducted for published research, with Google Scholar, CORE and British Ethos also …


Pengaruh Terapi Metotreksat Pada Pasien Artritis Reumatoid Terhadap Penurunan Fungsi Kognitif: Meta-Analisis Berdasarkan Telaah Sistematik, Fara Fauzia, Nurhayati Adnan Prihartono, Rudy Hidayat, Abirianti P. Araminta Jun 2023

Pengaruh Terapi Metotreksat Pada Pasien Artritis Reumatoid Terhadap Penurunan Fungsi Kognitif: Meta-Analisis Berdasarkan Telaah Sistematik, Fara Fauzia, Nurhayati Adnan Prihartono, Rudy Hidayat, Abirianti P. Araminta

Jurnal Penyakit Dalam Indonesia

Introduction. Rheumatoid arthritis (RA) is a systemic and chronic autoimmune disease involving the joints disorder as the main manifestations. Methotrexate (MTX) is currently still the drug of choice for RA treatment due to the good clinical response. However, there was a case reported by the American Geriatric Society in 2015 regarding the presence of reversible dementia after treatment with low-dose oral methotrexate. This study aimed to identify the effect of MTX treatment on cognitive disorder in RA patients.

Methods. The study protocol was registered with PROSPERO (CRD42023414937). A systematic literature search was conducted in Medline Embase database, Scopus, CENTRAL …


Global Health Governance And Its Role In Health Equity: The Case Of Covid-19, Wafa Abu El Kheir-Mataria Jun 2023

Global Health Governance And Its Role In Health Equity: The Case Of Covid-19, Wafa Abu El Kheir-Mataria

Theses and Dissertations

In the globalized world, we are living in, health became the joint responsibility of individuals, their governments, and the global health governance system. Moreover, based on the right to health, health equity is increasingly in demand, and adopting it to a global level has become an even more complex task to realize. This thesis is focuses on health equity at a global level. The main research questions addressed are: Is health equity present at an intercountry /global level? how is it related to Global Health Governance (GHG)? Is GHG performing well in achieving health equity? what are the reasons behind …


Extrinsic Allergic Alveolitis: A Systematic Review Of Hla-Dr In Pigeon Breeder’S Disease, Dylan Thibaut, Ryan A. Witcher, Anitha Kunnath, James Toldi Jun 2023

Extrinsic Allergic Alveolitis: A Systematic Review Of Hla-Dr In Pigeon Breeder’S Disease, Dylan Thibaut, Ryan A. Witcher, Anitha Kunnath, James Toldi

Advances in Clinical Medical Research and Healthcare Delivery

Abstract

Introduction: Pigeon Breeder’s Pneumonitis (PBP) results due to a complex pathophysiology that includes exposure to avian antigens. Susceptibility has been linked to human leukocyte antigen (HLA) class II, though consensus has not been reached. The goal of this systematic review is to further elucidate the association between PBP and HLA-DR subtypes.

Methods: Databases utilized included PubMed, Google Scholar, ScienceDirect, and Cochrane Library. Inclusion required a minimum of three studies in English presenting HLA-DR alleles of PBP and control subgroups. Exclusion was due to insufficient data or non-feasible control groups. Forest plots were created for HLA-DR subtypes’ association …


Measurement Models Matter: How Retrospective Calendar Versus Global Reports Yield Different Estimates Of Treatment Outcome, Margaret L. Paul Bs, Maria E. Meinerding Ms, Jeremiah Weinstock Phd, Meredith K. Ginley, James P. Whelan Phd, Rory A. Pfund May 2023

Measurement Models Matter: How Retrospective Calendar Versus Global Reports Yield Different Estimates Of Treatment Outcome, Margaret L. Paul Bs, Maria E. Meinerding Ms, Jeremiah Weinstock Phd, Meredith K. Ginley, James P. Whelan Phd, Rory A. Pfund

International Conference on Gambling & Risk Taking

Abstract: Retrospective reports are less accurate than objective measures of behavior and must be interpreted with consideration of the amount of distortion and error introduced by this methodology. The Gambling-Timeline Followback (G-TLFB) method is the gold standard retrospective assessment tool that is designed to minimize such error by asking for a specific recall of precise gambling behavior day-by-day using recall aids as compared to a global summation over time (e.g., how many gambling days in last month, how much money gambled in the last month). It remains an empirical question whether this difference in measurement format, G-TLFB versus global reports, …


Effects Of Exercise On Cardiopulmonary Function In Patients With Obstructive Sleep Apnea: A Systematic Review And Meta-Analysis, Jiale Peng, Hong Ren Feb 2023

Effects Of Exercise On Cardiopulmonary Function In Patients With Obstructive Sleep Apnea: A Systematic Review And Meta-Analysis, Jiale Peng, Hong Ren

International Journal of Physical Activity and Health

Obstructive sleep apnea (OSA) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Snoring and daytime sleepiness are the most common manifestations of OSA. Patients with OSA are considered to have poor cardiopulmonary function. Exercise has been proposed as a treatment for OSA that could lower apnea hypopnea indices (AHI) and improve sleep quality. Study shows that constantly aerobic exercise improved cardiopulmonary function in patients with chronic heart failure. However, whether exercise training will benefit cardiopulmonary functioning in patients with OSA is still in doubt. The purpose of this review is to investigate the …


Influence Of Physical Activity On Heart Rate Variability In Physically Inactive Adults: A Meta-Analysis, Lingsong Kong, Qin Yang Feb 2023

Influence Of Physical Activity On Heart Rate Variability In Physically Inactive Adults: A Meta-Analysis, Lingsong Kong, Qin Yang

International Journal of Physical Activity and Health

This meta-analysis aimed to examine the influences of physical activity (PA) interventions on heart rate variability (HRV) among healthy but physically inactive adults aged 18 to 65 years old. PubMed, SPORTDiscus and Web of Science online databases were searched in September 2021. The eligibility criteria were: (1) peer-reviewed articles in English; (2) randomized controlled trials; (3) healthy but physically inactive adults aged 18 to 65 years; (4) at least two-week PA intervention; (5) available frequency domain result. The data were extracted to a pre-designed form. The primary outcome of this study was the frequency domain of HRV, which included natural …


Modifiable Health Disparities And Cardiovascular Disease Risk Factors In Latino Migrant Seasonal Farmworkers: A Meta-Analysis, Cindy Mendez Jan 2023

Modifiable Health Disparities And Cardiovascular Disease Risk Factors In Latino Migrant Seasonal Farmworkers: A Meta-Analysis, Cindy Mendez

Nursing Theses and Dissertations

BACKGROUND: Cardiovascular disease is the leading cause of death in the United States (U.S.). Existing literature concluded that Latino migrant seasonal farmworkers endure higher rates of adverse health disparities and chronic diseases than the general U.S. population. However, research on the Latino migrant seasonal farmworkers’ modifiable health disparities (i.e., alcohol use and smoking) and cardiovascular disease risk factors (i.e., high cholesterol, diabetes mellitus, hypertension, and overweight/obesity) is scarce, particularly studies comparing male and female Latino migrant seasonal farmworkers. PURPOSE: This meta-analysis had two aims. First, examine whether male or female Latino migrant seasonal farmworkers in the U.S. have …


Neural Systems Underlying Rdoc Social Constructs: An Activation Likelihood Estimation Meta-Analysis, Rosario Pintos Lobo, Katherine L. Bottenhorn, Michael C. Riedel, Afra I. Toma, Megan M. Hare, Donisha D. Smith, Alexandra C. Moor, Isis K. Cowan, Javier A. Valdes, Jessica E. Bartley, Taylor Salo, Emily R. Boeving, Brianna Pankey, Matthew T. Sutherland, Erica D. Musser, Angela R. Laird Jan 2023

Neural Systems Underlying Rdoc Social Constructs: An Activation Likelihood Estimation Meta-Analysis, Rosario Pintos Lobo, Katherine L. Bottenhorn, Michael C. Riedel, Afra I. Toma, Megan M. Hare, Donisha D. Smith, Alexandra C. Moor, Isis K. Cowan, Javier A. Valdes, Jessica E. Bartley, Taylor Salo, Emily R. Boeving, Brianna Pankey, Matthew T. Sutherland, Erica D. Musser, Angela R. Laird

Psychology Faculty Publications

Neuroscientists have sought to identify the underlying neural systems supporting social processing that allow interaction and communication, forming social relationships, and navigating the social world. Through the use of NIMH’s Research Domain Criteria (RDoC) framework, we evaluated consensus among studies that examined brain activity during social tasks to elucidate regions comprising the “social brain”. We examined convergence across tasks corresponding to the four RDoC social constructs, including Affiliation and Attachment, Social Communication, Perception and Understanding of Self, and Perception and Understanding of Others. We performed a series of coordinate-based meta-analyses using the activation likelihood estimate (ALE) method. Meta-analysis was performed …


Meta-Analytic Connectivity Modelling Of Healthy Swallowing, Chris R. Tilton Jan 2023

Meta-Analytic Connectivity Modelling Of Healthy Swallowing, Chris R. Tilton

Honors Theses and Capstones

A quantitative, voxel-wise meta-analysis was performed to investigate the brain regions involved in healthy human swallowing. Studies included in the meta-analysis (1) examined water swallowing, saliva swallowing, or both, (2) included healthy, normal subjects, and (3) reported stereotaxic brain activation coordinates in standard space. Following these criteria, a systematic literature review identified 8 studies that met the criteria. An activation likelihood estimation (ALE) meta-analysis and meta-analytic connectivity modelling (MACM) analysis were performed with BrainMap software. Ten clusters with high activation likelihood were found in the bilateral precentral gyri, right insula, left declive, right medial frontal gyrus, right dorsal nucleus of …


Inferior Pedicle Breast Reduction In Egyptian Research: A Meta-Analysis Study, Ahmed Abd-Elrahman El-Shaboury, Mohammed Ibrahim Zidan, Al-Sayed Hussein El-Sharkawy Jan 2023

Inferior Pedicle Breast Reduction In Egyptian Research: A Meta-Analysis Study, Ahmed Abd-Elrahman El-Shaboury, Mohammed Ibrahim Zidan, Al-Sayed Hussein El-Sharkawy

Al-Azhar International Medical Journal

Background: Macromastia or breast hypertrophy is a common problem in the general female population, leading to debilitating symptoms and poor quality of life. Breast reduction surgery relieves disabling symptoms with great satisfaction, even though postoperative complications regularly occur.

Objective: The present study aimed to examine the inferior pedicle technique's reliability, safety, and effectiveness in breast reduction for female patients with macromastia in Egyptian patients.

Methods: We performed a systematic literature search on MEDLINE, Scopus, and Google Scholar for prospective and retrospective studies evaluating the inferior pedicle technique for breast reduction in Egypt.

Results: A total of 431 patients from 14 …


Tfos Lifestyle - Evidence Quality Report: Advancing The Evaluation And Synthesis Of Research Evidence, Laura E. Downie, Alexis Ceecee Britten-Jones, Ruth E. Hogg, Isabelle Jalbert, Tianjing Li, Gareth Lingham, Su-Hsun Liu, Riaz Quereshi, Ian J. Saldanha, Sumeer Singh, Jennifer P. Craig Jan 2023

Tfos Lifestyle - Evidence Quality Report: Advancing The Evaluation And Synthesis Of Research Evidence, Laura E. Downie, Alexis Ceecee Britten-Jones, Ruth E. Hogg, Isabelle Jalbert, Tianjing Li, Gareth Lingham, Su-Hsun Liu, Riaz Quereshi, Ian J. Saldanha, Sumeer Singh, Jennifer P. Craig

Articles

Evidence-based practice is a dominant paradigm in healthcare that emphasizes the importance of ensuring the translation of the best available, relevant research evidence into practice. An Evidence Quality Subcommittee was established to provide specialized methodological support and expertise to promote rigorous and evidence-based approaches for the Tear Film and Ocular Surface Society (TFOS) Lifestyle Epidemic reports. The present report describes the purpose, scope, and activity of the Evidence Quality Subcommittee in the undertaking of high-quality narrative-style literature reviews, and leading prospectively registered, reliable systematic reviews of high priority research questions, using standardized methods for each topic area report. Identification of …


The Potential And Peculiarities Of Perma: A Meta-Analysis Of Two Well-Being Measures With Working Samples, William P. Jimenez, Xiaoxiao Hu, Rebecca Garden, Asiye Zeytonli Jan 2023

The Potential And Peculiarities Of Perma: A Meta-Analysis Of Two Well-Being Measures With Working Samples, William P. Jimenez, Xiaoxiao Hu, Rebecca Garden, Asiye Zeytonli

Psychology Faculty Publications

In the first meta-analysis of the PERMA well-being framework (i.e., positive emotions, engagement, positive relationships, meaning, accomplishment), we cumulated 692 effect sizes (k = 33 independent samples, N = 10,050 workers). Average reliability did not meet the conventional ɑ = .70 threshold for engagement measured with the PERMA-Profiler or the Workplace PERMA Profiler or for negative emotions measured with the former. Overall, PERMA dimensions were strongly intercorrelated, and model comparisons suggested multidimensionality. We also summarized PERMA’s relationships with some conceptual antecedents (conscientiousness, loneliness); correlates (happiness, negative emotions); and outcomes (physical health, depressive symptoms, overall …


A Meta-Analysis Of Standard Versus Ultrasound-Assisted Catheter-Directed Thrombolysis In The Management Of Acute Pulmonary Embolism, Elizabeth S. Bruno, Mark Terence P. Mujer, Parth V. Desai, Yevgeniy Brailovsky, Amir Darki Jan 2023

A Meta-Analysis Of Standard Versus Ultrasound-Assisted Catheter-Directed Thrombolysis In The Management Of Acute Pulmonary Embolism, Elizabeth S. Bruno, Mark Terence P. Mujer, Parth V. Desai, Yevgeniy Brailovsky, Amir Darki

Division of Cardiology Faculty Papers

Background: Standard catheter-directed thrombolysis (SCDT) harnesses the therapeutic benefit of systemic thrombolytics while minimizing bleeding complications in patients presenting with pulmonary embolism (PE). Ultrasound-assisted catheter-directed thrombolysis (USAT) theoretically improves upon SCDT by disrupting fibrin and increasing the surface area exposed to thrombolytic agent. However, it is unclear if this translates into improved outcomes.

Methods: A systematic search of prior publications comparing SCDT and USAT in patients with intermediate or high-risk PE was conducted. Primary outcomes of interest were bleeding events, ICU and hospital length of stay. Secondary outcomes included changes in pulmonary artery systolic pressure (PASP), mean pulmonary artery pressure …


Exploring Demographic, Clinical And Exercise Prescription Moderators Of Resistance Exercise Effects On Objectively Measured And Patient-Reported Outcomes In Men With Prostate Cancer, Pedro Lopez Da Cruz Jan 2023

Exploring Demographic, Clinical And Exercise Prescription Moderators Of Resistance Exercise Effects On Objectively Measured And Patient-Reported Outcomes In Men With Prostate Cancer, Pedro Lopez Da Cruz

Theses: Doctorates and Masters

Information on specific prognostic factors such as the association of body composition with survival and tailored strategies considering demographic and clinical factors as well as the influence of exercise tolerance and compliance are required to establish targeted exercise prescription in men with prostate cancer. As a result, the purpose of this doctoral research is to: (i) investigate the role of body composition on overall survival in men with prostate cancer; (ii) determine which type of exercise/physical activity and/or dietary intervention is most effective for improving body composition outcomes in this population; (iii) examine the demographic and clinical characteristics of resistance …