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Full-Text Articles in Medicine and Health Sciences
Dietary Fish Oil Is Anti-Hypertrophic But Does Not Enhance Post-Ischemic Myocardial Function In Female Mice, Catherine E. Huggins, Claire L. Curl, Ruchi Patel, Peter L. Mclennan, Mandy L. Theiss, Thierry Pedrazzini, Salvatore Pepe, Lea M.D. Delbridge
Dietary Fish Oil Is Anti-Hypertrophic But Does Not Enhance Post-Ischemic Myocardial Function In Female Mice, Catherine E. Huggins, Claire L. Curl, Ruchi Patel, Peter L. Mclennan, Mandy L. Theiss, Thierry Pedrazzini, Salvatore Pepe, Lea M.D. Delbridge
Graduate School of Medicine - Papers (Archive)
Clinically and experimentally, a case for omega-3 polyunsaturated fatty acid (PUFA) cardioprotection in females has not been clearly established. The goal of this study was to investigate whether dietary omega-3 PUFA supplementation could provide ischemic protection in female mice with an underlying genetic predisposition to cardiac hypertrophy. Mature female transgenic mice (TG) with cardiac-specific overexpression of angiotensinogen that develop normotensive cardiac hypertrophy and littermate wild-type (WT) mice were fed a fish oil-derived diet (FO) or PUFA-matched control diet (CTR) for 4 wk. Myocardial membrane lipids, ex vivo cardiac performance (intraventricular balloon) after global no-flow ischemia and reperfusion (15/30 min), and …