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Full-Text Articles in Medicine and Health Sciences
Thiazolidinediones Inhibit Lipoprotein Lipase Activity In Adipocytes, Subramanian Ranganathan, Philip A. Kern
Thiazolidinediones Inhibit Lipoprotein Lipase Activity In Adipocytes, Subramanian Ranganathan, Philip A. Kern
Clinical and Translational Science Faculty Publications
The thiazolidinediones troglitazone and BRL 49653 improve insulin sensitivity in humans and animals with insulin resistance. Adipose tissue lipoprotein lipase is an insulin-sensitive enzyme. We examined the effects of thiazolidinediones on lipoprotein lipase expression in adipocytes. When added to 3T3-F442A, 3T3-L1, and rat adipocytes in culture, troglitazone and BRL 49653 inhibited lipoprotein lipase activity. This inhibition was observed at concentrations as low as 0.1 μM and within 2 h after addition of the drug. Lipoprotein lipase activity was inhibited in differentiated adipocytes as well as the differentiating cells. Despite this decrease in enzyme activity, these drugs increased mRNA levels in …
Diet Adherence Factors Affecting Diabetic Older Adults, Laurie Schluter
Diet Adherence Factors Affecting Diabetic Older Adults, Laurie Schluter
MSN Research Projects
Diabetes is a chronic disease which affects a significant portion of the United States population. Effective management requires adherence to a prescribed dietary regimen. Many diabetics have difficulty adhering to their recommended diet. This descriptive study explored diabetic diet adherence in older adults. The following research question guided the study: What are the factors that affect diabetic diet adherence in older adults? Sr. Callista Roy's adaptation theory provided direction for the study. Thirty two diabetic patients age 45 years and older in Louisiana comprised the sample. The sample included rural and urban patients of a home health agency and a …
Impact Of A Multidisciplinary Education Class On Knowledge And Health-Promoting Behaviors In Persons With Type 2 Diabetes Mellitus In Rural Mississippi, Carmen Leigh Parks
Impact Of A Multidisciplinary Education Class On Knowledge And Health-Promoting Behaviors In Persons With Type 2 Diabetes Mellitus In Rural Mississippi, Carmen Leigh Parks
MSN Research Projects
Prevalence rates of known diabetes mellitus continue to increase in the United States. However, studies show that people can reduce their risks of long-term complications by maintaining adequate blood sugar control. Good metabolic control, however, can be very difficult for persons with diabetes because it requires knowledge, motivation, lifestyle adjustments, close monitoring, and ongoing support from a health care team. The purpose of this quasi-experimental pretest/posttest study was to determine the impact of a multidisciplinary education class on knowledge and health-promoting behaviors in persons with type 2 diabetes in rural Mississippi. Pender's Health Promotion Model was used as the theoretical …
Effects Of Tumor Necrosis Factor-Α On Glucose Metabolism In Cultured Human Muscle Cells From Nondiabetic And Type 2 Diabetic Subjects, Theodore P. Ciaraldi, Leslie Carter, Sunder Mudaliar, Philip A. Kern, Robert R. Henry
Effects Of Tumor Necrosis Factor-Α On Glucose Metabolism In Cultured Human Muscle Cells From Nondiabetic And Type 2 Diabetic Subjects, Theodore P. Ciaraldi, Leslie Carter, Sunder Mudaliar, Philip A. Kern, Robert R. Henry
Clinical and Translational Science Faculty Publications
The effects of tumor necrosis factor-a (TNFα) on glucose uptake and glycogen synthase (GS) activity were studied in human skeletal muscle cell cultures from nondiabetic and type 2 diabetic subjects. In nondiabetic muscle cells, acute (90-Min) exposure to TNFα (5 ng/ml) stimulated glucose uptake (73 ± 14% increase) to a greater extent than insulin (37 ± 4%; P < 0.02). The acute uptake response to TNFα in diabetic cells (51 ± 6% increase) was also greater than that to insulin (31 ± 3%; P < 0.05). Prolonged (24-h) exposure of nondiabetic muscle cells to TNFα resulted in a further stimulation of uptake (152 ± 31%; P < 0.05), whereas the increase in cells from type 2 diabetics was not significant compared with that in cells receiving acute treatment. After TNFα treatment, the level of glucose transporter-1 protein was elevated in nondiabetic (4.6-fold increase) and type 2 (1.7-fold) cells. Acute TNFα treatment had no effect on the fractional velocity of GS in either nondiabetic or type 2 cells. Prolonged exposure reduced the GS fractional velocity in both nondiabetic and diabetic cells. In summary, both acute and prolonged treatment with TNFα up-regulate glucose uptake activity in cultured human muscle cells, but reduce GS activity. Increased skeletal muscle glucose uptake in conditions of TNFα excess may serve as a compensatory mechanism in the insulin resistance of type 2 diabetes.
Diabetic Complications In Experimental Models, Yusuf Öztürk, V. Melih Altan, Nuray Ari
Diabetic Complications In Experimental Models, Yusuf Öztürk, V. Melih Altan, Nuray Ari
Turkish Journal of Medical Sciences
In this review, the aim is to focus on diabetic complications in experimental models of diabetis. For this purpose, com-plications, chiefly seen in log-term periods in various systems of animals, such as cardio vascular and nervous systems, gastrointestinal, urogenital and respiratory tracts, etc., have been stated. Furthermore, novel and conventional therapeutic approaches in their management have also been briefly discussed.