Medicine and Health Sciences Commons^™

The Nature And Meaning Of Insulin Pump Use In Emerging Adults With Type 1 Diabetes, Donna G. Hood

Nursing Theses and Dissertations

Emerging adults (ages 18-25) with type 1 diabetes are a vulnerable population as they transition from the family home and their pediatric healthcare providers and deal with multiple competing demands. There is very little literature addressing those in this developmental group who use insulin pump technology for diabetes self-management. Listening to the voices of emerging adults who use insulin pump technology will increase our understanding of their experience and will give health care providers the opportunity to develop evidence based practice based on their lived experiences. The qualitative research, using the hermeneutic phenomenological approach described by Max van Manen, provides …

Elucidating The Function Of Transplanted Islets Of Langerhans And Predicting Their Ability To Reverse Diabetes, Andrew R. Pepper

Electronic Thesis and Dissertation Repository

Type 1 diabetics require daily injections of exogenous insulin to control hyperglycemia. Unfortunately, patients are still plagued by vascular and hypoglycemic complications. Beta cell replacement therapy by either whole organ pancreas or islet transplantation has been shown to restore carbohydrate control to these patients. A major barrier to successful islet transplantation is the lack of a reliable pre-transplant assay of post-transplant function thus providing an objective measure of whether a particular islet isolation should be transplanted. Such an assay would also prove to be a valuable tool in the experimental evaluation of innovative islet isolation strategies and technologies. The initial …

The Use Of Provider Audit And Feedback On Improving Hypertension Control In The Type 2 Diabetic Population, Kara Painton

Evidence-Based Practice Project Reports

As the seventh leading cause of death, diabetes affects more than 25 million Americans and contributes to major cardiovascular diseases and complications (CDC, 2011). The cost of care for these Americans is astounding: $174 billion dollars was spent on diabetes care in 2007 (ADA, 2011). Furthermore, an estimated 75% of patients with type 2 diabetes have concomitant hypertension, and nearly one-half of these patients have uncontrolled hypertension (Thomas & Kodack, 2011; USDHHS, 2011). An initial chart audit at an outpatient, rural clinic in east central Illinois revealed that 90% of the type 2 diabetic population had concomitant hypertension, and only …

Inpatient Glycemic Management: Glucose Control Relationship With Hospital Variables, Discharge Planning And Education, Crisamar Javellana-Anunciado Phd, Fnp-Bc, Rn

Dissertations

This dissertation study examined the relationship of glucose control with clinical outcomes, costs, discharge planning and education. Extant studies showed that hyperglycemia, in the presence or absence of a diabetes diagnosis, is prevalent in hospitalized patients. Hyperglycemia is found in one-third of all hospital admissions and is linked to poor clinical outcomes and increased healthcare costs. Furthermore, clinical evidence suggests that lack of discharge coordination associated with medical errors and readmission. This entire body of work contains three distinct sections: Two manuscripts and a grant proposal. The two manuscripts in this study were based on more current retrospective data at …

Beta-2-Adrenergic Receptor Regulates Insulin Signaling To Reduce Cell Death In Müller Cells, Robert Jason Walker

Theses and Dissertations (ETD)

No abstract provided.

Understanding The Roles Of Non-Homologous End Joining And P53 After Dna Damage, Omid Tavana

Dissertations & Theses (Open Access)

The inability to maintain genomic stability and control proliferation are hallmarks of many cancers, which become exacerbated in the presence of unrepaired DNA damage. Such genotoxic stresses trigger the p53 tumor suppressor network to activate transient cell cycle arrest allowing for DNA repair; if the damage is excessive or irreparable, apoptosis or cellular senescence is triggered. One of the major DNA repair pathway that mends DNA double strand breaks is non-homologous end joining (NHEJ). Abrogating the NHEJ pathway leads to an accumulation of DNA damage in the lymphoid system that triggers p53-mediated apoptosis; complete deletion of p53 in this system …

Determination Of The Molecular Mechanisms Of Hyperglycemia-Induced Changes In Cav3.2 Calcium Channel Properties, Ginny Marie Keeling

Master's Theses

Hyperglycemia can cause altered excitability due to increased CaV3.2 T-type calcium channel function, bestowing diabetics an increased neuropathy risk. The objective of this study was to understand the molecular mechanisms of increased CaV3.2 function during hyperglycemia in vitro, which leads to a 58% increase in current density and increased channel open probability (PO), among other changes. Two major findings are reported in this study:

1) The enzymatic elimination of extracellular N-acetylneuraminic acid (NANA) moieties reversed the increase in current density and the shift in PO, showing that hyper-glycosylation alters channel function in disease.

2) Treatment with GM1 (a ganglioside highly …

Self-Care Agency And Self-Care Practice Of Adult African Americans With Type 2 Diabetes, Martha Eddings

Nursing Theses and Capstone Projects

The purpose of the study was to identify and examine the concepts of self-care agency and self-care practice of African American adults diagnosed with type 2 diabetes, living in the local community. The research questions addressed were: 1) What is the self-care agency of adult African Americans diagnosed with type 2 diabetes? 2) What is the self-care practice of adult African Americans diagnosed with type 2 diabetes? 3) Is there a relationship between self-care agency and self-care practice in adult African Americans diagnosed with type 2 diabetes? The Denyes Self-Care Agency Instrument (DSCAI-90) and the Denyes Self-Care Practice Instrument (DSCPI-90) …

Type 2 Diabetes And Insomnia: Impact On Metabolic Control, Cheryl Lee Tannas

Wayne State University Dissertations

Diabetes is one of the most serious health challenges in the United States, affecting nearly 21 million Americans. The goal of diabetes management is to maintain the blood glucose close to normal to prevent diabetic complications and therefore extending life expectancy and improving quality of life. Research now indicates a relationship of the quantity and quality of sleep to glycemic control in type 2 diabetics. No research on the impact of insomnia on diabetes prevention and/or management was found in the literature. The purpose of this 11 week intervention study was to examine the effects of participation in Cognitive Behavioral …

The Role Of Vascular Endothelial Growth Factor At The Blood-Brain Barrier In Diabetes, Aileen J. Marcelo

Theses, Dissertations and Capstones

Diabetes is a risk factor for stroke and vascular dementia. Clinical studies using gadolinium-magnetic resonance imaging techniques have shown diabetic patients exhibit a permeability increase at the blood-brain barrier (BBB) (Starr et al, 2003). The BBB, a vascular interface at the level of brain microvascular vessels, functions to provide nutrients and oxygen from the peripheral circulation, mediates waste efflux from the brain, and protects the brain from toxins. These functions are due to the presence of tight junction proteins. Animal studies have shown increased BBB permeability is due to a decrease in these proteins (Hawkins et al, 2007). Based on …

Barriers To Diabetes Self-Management In African American Women, Christine Little-Gregory

Nursing Theses and Capstone Projects

Diabetes is a global epidemic and is a leading cause of disease-related death. In the United States, diabetes is the most common chronic disease affecting 23.6 million Americans or 7.8% of the population (Centers for Disease Control, 2010a). African American women have the highest prevalence of diabetes. Health promotion in the form of diabetes self-management is the key to reducing this urgent disparity. This descriptive study sought to identify barriers to diabetes self-management and identify relationships associated with self-management in this population. This study was conducted using a convenience sampling of African American women with diabetes who were surveyed to …

Do Inhaled Corticosteroids Cause An Increased Risk For Developing Or Worsening A Patient’S Diabetes Mellitus?, Jarrod R. Luttjohann

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE The objective of this selective EBM review is to determine whether or not inhaled corticosteroids (ICS) cause an increased risk for developing or worsening a patient’s diabetes mellitus (DM).

STUDY DESIGN Review of three English language primary studies published in 1993, 2009 and 2010.

DATA SOURCES A nested case-control analysis, a randomized control trial and a prospective randomized, doubleblind, double-dummy, placebo-controlled, crossover investigation comparing the onset and/or progression of diabetes mellitus in patients using ICS were found using Ovid MEDLINE, PubMed, and Cochrane databases.

OUTCOMES MEASURED Incidence or progression of diabetes was measured using a combination of oral glucose …

Is Acupuncture An Effective Treatment For Diabetic Peripheral Neuropathy?, Sherri A. Kowalczuk

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not acupuncture is an effective treatment for diabetic peripheral neuropathy

STUDY DESIGN: Review of three English language primary studies, one published in 2007 and two of which were published in 2010.

DATA SOURCES: Randomized controlled trials investigating the use of acupuncture for the treatment of diabetic peripheral neuropathy (DPN). Sources were found using PubMed and Cochrane databases.

OUTCOMES MEASURED: The outcomes measured include the severity of pain from DPN, blood glucose control, and effects on quality of life such as sleep, mood states, and gain or loss …

Sugar Consumption And Cognitive Aging In The Swedish Adoption/Twin Study Of Aging, Shyam Seetharaman

USF Tampa Graduate Theses and Dissertations

Abstract

Consumption of foods high in sugar content has been linked with the development of metabolic abnormalities such as cardiovascular disease and type II diabetes, major sources of global health concerns. Although the detrimental consequences of high intake of sugar on abnormal metabolic processes are established, it is not known how this association affects (or accelerates) cognitive aging.

The current project was based on data from the Swedish Adoption/Twin Study of Aging (SATSA) to test the hypothesis that high refined sugar intake contributes to accelerated trajectories of cognitive decline assessed longitudinally. Trajectories of cognitive change were assessed as a function …

Effectiveness Of Insulin Pump Use In Controlling Blood Glucose In Type 1 Diabetes Mellitus Patients, Nadia M. Saad

Master's Theses and Doctoral Dissertations

No abstract provided.

Access And Barriers To Diabetic Self Care Education And Support Groups In A Rural Southern Minnesota Community, Elizabeth Waters

All Graduate Theses, Dissertations, and Other Capstone Projects

Diabetic education and support groups promote self care, improve health outcomes, and decrease health care costs. Self care, an important aspect of diabetes care, can be promoted through diabetes education and support groups. Few studies have been done to explore rural population's access to and attendance of diabetes self care education and support groups. The purpose of this qualitative study was to determine if residents of a rural southern Minnesota community have access to diabetes education and support groups and what barriers they face to attending the groups. The understanding gained through this study will help to develop nursing interventions …

Targeting Mitochondrial Function In Diabetic Nephropathy, Colin Reily

All ETDs from UAB

TARGETING MITOCHONDRIAL FUNCTION IN DIABETIC NEPHROPATHY The incidence of diabetes has increased to epidemic proportions over the last 50 years, due to a complex interaction of lifestyle and dietary factors. Changes in physical activity, caloric intake, and the composition of foods consumed over the last century are thought to interact with metabolic syndrome prone subpopulations leading ultimately to diabetes. It is widely accepted that chronic hyperglycemia in the blood characterizes the diabetic condition. Since the discovery of insulin therapy in the first half of the 20th century, diabetics have extended their lifespan considerably, but at the cost of increased morbitity …

Life Course Socio-Economic Measures As Predictors Of Bmi Trajectories And Prevalence Of Diabetes In Adult Life, Tabassum Zarina Insaf

Legacy Theses & Dissertations (2009 - 2024)

Few studies have analyzed the effect of lifecourse socioeconomic position (LSEP) on racial disparities in body mass index (BMI) trajectories and Diabetes. Four waves of the Americans' Changing Lives study (1986-2002) were used to compute BMI trajectories and diabetes prevalence for 3497 Black and White participants. Multivariate associations of LSEP variables (father's education, perceived childhood SEP, education, income, wealth and financial stress) with baseline BMI and BMI change were assessed using mixed models. We also evaluated whether disparate LSEP predictors are influential in Blacks as compared to Whites. Finally we evaluated the presence of latent, pathway and cumulative models of …