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Full-Text Articles in Medicine and Health Sciences
The Role Of Trib3 In Insulin Resistance: Its Action As Nutrient Sensor And Regulator Of Insulin Action, Jiarong Lamiquiz
The Role Of Trib3 In Insulin Resistance: Its Action As Nutrient Sensor And Regulator Of Insulin Action, Jiarong Lamiquiz
All ETDs from UAB
THE ROLE OF TRIB3 IN INSULIN RESISTANCE: ITS ACTION AS NUTRIENT SENSOR AND REGULATOR OF INSULIN ACTION JIARONG LIU LAMIQUIZ PATHOLOGY ABSTRACT Insulin resistance is a hallmark of Type 2 diabetes (T2DM). A reduced capacity for insulin to stimulate increases in glucose uptake and glucose oxidation in insulin sensitive tissues, such as skeletal muscle and adipose tissue, are common defects in patients with insulin resistance, T2DM, and other related diseases. Tribbles homolog 3 (TRIB3) has been demonstrated to play a role in insulin resistance by serving as a negative regulator of Akt in mouse liver, fat, and pancreas. In a …
Vitamin D And Insulin Sensitivity Among African American And European American Adolescents And Adults, Jessica Alejandra Alvarez
Vitamin D And Insulin Sensitivity Among African American And European American Adolescents And Adults, Jessica Alejandra Alvarez
All ETDs from UAB
Adequate vitamin D status is associated with a reduced risk for type 2 diabetes (T2DM); the relationship may be mediated by insulin sensitizing effects of vitamin D. African Americans (AA) are at a greater risk for T2DM and insulin resistance, as well as vitamin D deficiency, compared to European Americans (EA). The primary objective of this dissertation was to investigate the independent relationships of vitamin D with various measures of insulin sensitivity. Investigations were performed in a series of studies involving adolescent and adult female cohorts. The intravenous glucose tolerance test-derived insulin sensitivity index (SI) or the oral glucose tolerance …