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Full-Text Articles in Medicine and Health Sciences
Effects Of Short Term High Fat Diet On Obesity And Perivascular Adipose Structure And Function In Mice : Role Of Aldose Reductase, And Aldehyde Metabolizing Enzyme., Daniel Alan Murphy
Effects Of Short Term High Fat Diet On Obesity And Perivascular Adipose Structure And Function In Mice : Role Of Aldose Reductase, And Aldehyde Metabolizing Enzyme., Daniel Alan Murphy
College of Arts & Sciences Senior Honors Theses
This study was undertaken to determine the effects of high fat diet and aldose reductase deficiency on the structure and function of murine perivascular adipose tissue. Wild type (WT) (C57 bl/6) and aldose reductase knockout (AR-null) mice were aged to 8 or 18 weeks on a normal chow diet then some were switched to a high fat diet for 4 weeks while others remained on the control diet for the same amount of time. Following 4 weeks, mice were euthanized PVAT was analyzed. High fat feeding significantly increased body fat percentage in both age groups of mice and the area …
Cardiovascular Disease Among Diabetic Women With Bilateral Oophorectomy., Duke Appiah
Cardiovascular Disease Among Diabetic Women With Bilateral Oophorectomy., Duke Appiah
Electronic Theses and Dissertations
Cardiovascular Disease (CVD) is the leading cause of death in women and the risk is increased threefold in diabetics. In postmenopausal diabetics, the ovary responds to hyperinsulinemia by increasing secretion of testosterone precursors which increases the risk of CVD. Data from the National Health and Nutrition Examination Survey (1988-2010) and the Study of Osteoporotic Fractures were used to test the hypothesis that a history of bilateral oophorectomy -surgical removal of both ovaries-would decrease the risk of CVD among postmenopausal diabetic women due to reduced androgen levels. Logistic regression, discrete time logit model, B-Spline regression and Cox proportional hazards models were …