Medicine and Health Sciences Commons^™

The Effect Of Depression And Antidepressants On Cost, Survival And Adherence To Hormone Therapy In Breast Cancer, Virginia Noxon

Theses and Dissertations

Introduction: Breast cancer patients with a depression diagnosis before or after cancer diagnosis have increased cost, shorter survival time and reduced adherence to hormone therapy. Treating depression in these patients should improve these outcomes; however, there is scarce literature on this topic. Currently, no study has determined the association of concurrent depression while adjusting for a history of depression or treating depression with antidepressants with cost, survival and adherence to hormone therapy. This study has two objectives: 1) to determine the association of concurrent depression with cost, survival and adherence to hormone therapy adjusting for a history of depression 2) …

A Brief Rational Disputation Exercise Enhances Cardiovascular, Anxiety, And Affective Recovery Following Worry-Recall, Michelle Rosalie Di Paolo

Theses and Dissertations

Rational Emotive Behavior Therapy (REBT) (Ellis, 1958), educates a client on the relationship between one’s irrational beliefs (IBs) and the dysfunctional emotional/behavioral consequences of maintaining those beliefs such as symptoms of anxiety, depression, and sleep dysfunction (Ellis, Gordan, Neenan, & Palmer, 1997), symptoms also commonly correlated with high trait perseverative cognition (PC; Verkuil, Brosschot, de Beurs, & Thayer, 2009). In addition to symptoms of anxiety and depression, high levels of PC, a construct comprised of measures of trait worry and rumination, have been linked to acute cardiovascular (CV) health concerns that overtime when left unmitigated may lead to chronic conditions …

The Relationship Between The Poor Parenting In Childhood And Current Adult Symptoms Of Anxiety And Depression: Attachment As A Mediator, Kayla Lynn Burningham

Theses and Dissertations

Both anxiety and depression have been shown to be a result of early negative attachment experiences. The quality of parenting is one variable that affects attachment security, therefore correlating with the development of anxiety and depression in adulthood. The purpose of this study was to examine the mediating effect of attachment in the relationship between mother and father's parenting in childhood and adult symptoms of anxiety and depression. The study focused on 680 married or remarried heterosexual couples that took the RELATE questionnaire between 2011 and 2013. Results indicated insecure attachment mediates the relationship between poor parenting and symptoms of …

Exploring The Concept Of Human Oct3 Inhibitors As A Novel Class Of Antidepressants, Kavita A. Iyer

Theses and Dissertations

The Dukat laboratory developed 2-amino-6-chloro-3,4-dihydroquinazoline (A6CDQ) as a 5-HT₃ receptor ligand. A6CDQ and one of its positional isomers, the 7-chloro analog A7CDQ, produced antidepressant-like effects in the mouse tail suspension test (TST). We investigated and systematically ruled out a solely 5-HT₃ receptor or hSERT mediated mechanism of antidepressant-like effect for both A6CDQ and A7CDQ.

The role of organic cation transporter 3 (OCT3) as an alternative mechanism in the regulation of neurotransmitters including serotonin (5-HT) and the therapeutic potential of targeting hOCT3 to achieve antidepressant effects has been established. By virtue of possessing protonatable nitrogen atoms, 2-aminodihyroquinazolines could potentially …

Behaviorally Induced Insufficient Sleep Syndrome And Insomnia: Prevalence And Relationship To Depression In College Students, Allison Baylor

Theses and Dissertations

Background: College students are at increased risk for general sleep issues as well as specific disorders, including Behaviorally Induced Insufficient Sleep Syndrome (BISS) and insomnia. These disorders can have deleterious daytime consequences, which can be compounded by exacerbating depression. The present study aims to establish college prevalence of BISS/insomnia, to characterize sleep characteristics in this sample, and to compare depression across BISS/insomnia.

Methods: Data from a college risk behaviors and health study (n=989) was used. Insomnia and BISS were defined as mutually exclusive disorders, using ICD-10/DSM-5 criteria, and Pittsburg Sleep Quality Index items.

Results: Overall, the results of this study …

Depression Among Pregnant Latinas In South Carolina, Andrew Fogner

Theses and Dissertations

The aim of the study was to determine the prevalence of depression among pregnant Latinas. To bring to light the importance of prenatal depression prevention, we assessed the effect of the quality of healthcare providers among South Carolina Latinas (n=171). Women answered a validated CES-D and were categorized as depressed (score >16). In multivariate analyses, good perception of quality of healthcare was more likely among women who were not depressed; adjusted odds ratio of 0.75, 95% confidence interval 0.37 – 1.55. The findings show the need for tailoring healthcare to Latinas with prenatal depression prevention. It is imperative to understand …