Medicine and Health Sciences Commons^™

The Predictability Of C-Reactive Protein, Lipoprotein-Associated Phospholipase A2, And Depression On Later Health Outcomes In Patients Experiencing A First-Time Stroke, Mary King Brethour

All ETDs from UAB

Stroke is the third leading cause of death and the most common cause of neurologic disability for adults in developed nations. Strokes trigger an acute inflammatory response prompted by brain tissue injury at the infarct site and the surrounding ischemic penumbra raising plasma levels of inflammatory markers. C-reactive protein (CRP), an acute-phase inflammatory marker, has been significantly correlated with infarct size and post-stroke complications. Lipoprotein-associated phospholipase A2 (Lp-PLA2) may also predict long-term cardiovascular risk in the stroke population. In addition to physiologic changes, up to 60% of all stroke survivors are known to experience depression, which may contribute to decreased …