Medicine and Health Sciences Commons^™

Is S-Adenosylmethionine (Same) An Effective Drug To Help Treat Patients With Depression?, Cassidy M. Flanigan

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of the selective EBM review is to determine whether or not “Is Sadenosylmethionine (SAMe) an Effective Drug to Help Treat Patients with Depression?”

Study Design: A systematic review of three randomized controlled trials (RCTs) published between 2016-2020.

Data Sources: All three RCTs were discovered using PubMed. The articles were published in English in peer-reviewed journals and selected based on applicability to the clinical question.

Outcome Measured: A reduction in depressive symptoms was the outcome measured in all three studies using the Montgomery-Asbery Depression Rating Scale (MADRS). The mean change in baseline was calculated once intervention was received. …

Do Probiotics Decrease Depressive Symptoms In Patients With Low Mood?, Kaitlyn Talt

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine, “Do probiotics decrease depressive symptoms in patients with low mood?”

Study Design: A systematic review of three double blind, randomized control trials (RCTs) published between 2016 and 2019.

Data Sources: All three RCTs were found using PubMed and published in English in peer-reviewed journals. The articles were chosen based on their attention to patient-oriented evidence that matters (POEMS) and their relevance to the clinical question.

Outcome Measured: All three articles utilized either the Beck Depression Index (BDI) and/or the Depression Anxiety Stress Scale (DASS) to measure the severity of …

Does Yoga Decrease Self-Report Of Antenatal Depression Among Healthy Pregnant Women Aged 18-40 Years Old In The 2nd And 3rd Trimesters?, Emily J. Moore

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not yoga decreases self-report of antenatal depression among healthy pregnant women aged 18-40 years old in the 2nd and 3rd trimesters.

Study Design: Review of three randomized controlled trials (RCTs) published in peer reviewed journals in 2013 and one RCT published in a peer reviewed journal in 2012 were used.

Data Source: Data sources included articles published in English in peer reviewed journals found using PubMed. Articles were selected based on their relevance to my clinical question.

Outcomes Measured: All four studies measured self-report of symptoms of …

Is Dance/Movement Therapy An Effective Treatment For Depression In Students?, Jillian R. Ranker

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective evidence-based medicine (EBM) review is to determine whether or not Dance/Movement Therapy (DMT) is an effective treatment for depression in students.

STUDY DESIGN: Systematic review of three published, randomized controlled trials (RCTs) between 2005 and 2013, all English language

DATA SOURCES: Three RCTs analyzing DMT use in depression were found using PudMed

OUTCOMES MEASURED: Decrease in depressive symptoms, measured by the Beck Depression Scale, a self-rated health questionnaire, and Symptom Check List-90-Revision (SCL- 90-R)

RESULTS: DMT resulted in lessened depressive symptoms for students in all three RCTs. Jeong et al. observed a significant decrease …

Does Exogenous Melatonin Improve Quality Of Sleep In Patients Experiencing Sleep Disturbances Secondary To Chronic Diseases?, Blessen B. Thomas

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Does exogenous melatonin improve quality of sleep in patients experiencing sleep disturbances secondary to chronic diseases?”

Study Design: Three Randomized, placebo-controlled studies (RCT) published in 2010, 2013 and 2008. Data Sources: All RCTs searched and located using PubMed database.

Outcomes Measured: Clinical outcome for all three articles using quality of sleep or quality of life questionnaires such as the Leeds Sleep Evaluation. All of which evaluated POEMs, and were self reported by participants.

Results: In a randomized control study (RCT) by Serfaty et al, sleep quality …

Is Crocus Sativus L. As Effective As Fluoxetine For The Treatment Of Mild To Moderate Depression In Adults Aged 18-55?, Mobina A. Noory

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this EBM review is to determine whether or not Crocus Sativus L. is as effective as Fluoxetine for the treatment of mild to moderate depression in adults aged 18-55.

Study Design: Systematic review of three English language, double-blind randomized controlled trials published between 2005-2007.

Data Source: Three double-blind randomized controlled trials published in peer-reviewed journals comparing the effectiveness of Crocus Sativus L. vs. Fluoxetine or placebo for the treatment of mild to moderate depression in adults were found using PubMed and Ebscohost.

Outcomes Measured: In all three articles the outcomes measured were improvement in depression symptoms …

Does Black Cohosh Improve Anxiety/Depression Symptoms In Women Who Are Postmenopausal?, Priya Patel

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this systematic review is to determine is Black Cohosh effective for reducing anxiety/depression symptoms in postmenopausal women?

DESIGN: Review of three English language primary randomized controlled studies published from 2005-2009.

DATA SOURCES: Randomized, double blind, placebo-controlled trials comparing Black Cohosh to placebo or hormonal therapies were found using PubMed and Cochrane databases.

OUTCOMES MEASURED: Each of the three trials assessed the efficacy and clinical improvement in anxiety symptoms with the use of Black Cohosh. Studies utilized to measure change in anxiety symptoms included Harrison Anxiety Rating (HAM), Symptom Rating Test (SRT), and Kupperman Test.

RESULTS: Two …

Do N3 Fatty Acid Supplements Effect Depressive Symptoms Post Cardiovascular Event In Men And Women Ages 40 And Older?, Lindsey G. Caton

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not n-3 fatty acids have an effect on depressive symptoms post cardiovascular event in men and women ages 40 and older.

STUDY DESIGN: Systematic review of three English language random controlled trials published between 2011-2012.

DATA SOURCES: Two randomized controlled trials published after 2011 comparing the effects of n-3 fatty acid supplementation on depressive symptoms post cardiovascular event and one randomized controlled trial comparing n-3 fatty acid supplementation effects on depressive symptoms in elderly patients with diagnosed depression. The studies were obtained using the …

Does The Use Of Varenicline For Smoking-Cessation Therapy Create Or Increase Depression In Patients Without Existing Depressive Illness?, Brett R. Brown

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not the use of varenicline for smoking-cessation therapy creates or increases depression in patients without existing depressive illness.

STUDY DESIGN: Review of two randomized controlled trials published in 2011 and one observational cohort study published in 2009, all English language.
DATA SOURCES: Two randomized, double-blind, controlled clinical trials comparing varenicline to placebo in smoking cessation, and one observational cohort study comparing varenicline use within subjects. All articles were found using PubMed and EBSCO.

OUTCOMES MEASURED: Changes in depression was evaluated using the MontgomeryÅsberg Depression Rating Scale …

Does Laughter Therapy Improve Symptoms Of Depression Among The Elderly Population?, Audrey L. Shaw

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or
not laughter therapy improves symptoms of depression among the elderly population.

STUDY DESIGN: A review of three studies written in the English language published between 2007 and 2011.

DATA SOURCES: Two randomized controlled trials and one pilot study comparing the effect of laughter therapy on depression were found using PubMed, Medline, OVID, and Cochrane databases.

OUTOMES MEASURED: Outcomes measured in the studies included depression, quality of life, and life satisfaction.

RESULTS: Laughter therapy was shown to be beneficial as both an independent …

Is Hypnotherapy An Effective Treatment For Depression?, Simone Youssef

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this EBM paper is to determine whether or not hypnotherapy is an effective treatment for depression.

STUDY DESIGN: Review of two English language randomized controlled trials and one case study published in 2007, 2009, and 2010.

DATA SOURCES: Two randomized controlled trials and one case study reviewing the effectiveness of hypnotherapy on depression were found using PubMed, Medline, and CINAHL.

OUTCOMES MEASURED: Depression was measured through the Beck Depression Inventory (BDI- II), which is a 21-question multiple choice self-report inventory based on scores of 0-63, with higher scores signifying more severe depressive …

Does Fish Oil Supplementation (Omega-3 Pufa) Cause Mood Improvement In Adults With Depression, Lauren Cabana

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this systematic review is to determine whether or not “Does fish oil supplementation (omega-3 PUFA) cause mood improvement in adults with depression?”