Medicine and Health Sciences Commons^™

Generation Of Crispr Knockout Of Idh1 In Pancreatic Ductal Adenocarcinoma Cell Line: An Optimal Model To Study Pancreatic Cancer Metabolic Reprogramming, Katerina Dukleska, Md, Mahsa Zarei, Phd, Ali Vaziri-Gohar, Phd, Charles J. Yeo, Md, Jonathan Brody, Md, Jordan M. Winter, Md

Department of Surgery Posters

Introduction

• Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related death in the US.

• PDA is resistant to conventional chemotherapy; however, mechanisms that contribute to this chemoresistance are not well-described.

• The tumor microenvironment in PDA has a dense stromal reaction, which is thought to result in low oxygen and low nutrient conditions (Feig, C., et al. 2012).

• Isocitrate Dehydrogenase 1 (IDH1) has been identified as an enzyme that plays an important role in chemoresistance in PDA (Zarei, M., et al. In progress).

• We sought to establish an IDH1 knockout cell line to further …

Total Parenteral Nutrition In Patients Following Pancreaticoduodenectomy: Lessons From 1184 Patients, Cullen Worsh, Talar Tatarian, Md, Pgy-4, Awinder Singh, Michael J. Pucci, Md, Jordan M Winter, Md, Charles J. Yeo, Md, Harish Lavu, Md

Department of Surgery Posters

Poster presented at Sigma XI Student Research Day at Thomas Jefferson University.

Background:

Total parenteral nutrition (TPN) has historically been used conservatively in the management of patients after pancreaticoduodenectomy (PD).

In this study, we evaluate the indications for and outcomes associated with TPN use in a high-volume pancreatic surgery center.

Surgical Apgar Score (Sas) Predicts Perioperative Morbidity And Length Of Stay In Patients Undergoing Esophagectomy At A High-Volume Center, Danica Giugliano, Md, Andrew Morgan, Francesco Palazzo, Md, Nathaniel R. Evans Iii, M.D., Ernest L Rosato, Md, Adam C. Berger, Md, Benjamin E Leiby, Phd

Department of Surgery Posters

Background:

Esophagectomy is a procedure that carries considerable morbidity. Many studies have evaluated factors to predict patients at risk and improve clinical outcomes. The aim of this study was to determine whether the SAS predicts complications, length of stay, and anastomotic leak for patients undergoing esophagectomy at a high-volume institution.

Evaluating The Sensitivity Of The Nanostrong Ncounter® Analysis System To Determine Gene Expression Changes Associated With Chemotherapy Treatment, Katerina Dukleska, Md, Christopher W. Schultz, Bs, Mahsa Zarei, Phd, David Mckeown, Md, Charles J. Yeo, Md, Jonathan Brody, Phd, Jordan M. Winter, Md

Department of Surgery Posters

Introduction

• Pancreatic ductal adenocarcinoma (PDA) remains a deadly disease with a 5-year survival of 8% for all stages combined (Siegel RL et al.). Currently, it’s the third leading cause of cancer-related deaths in the United States and by 2020 it is projected to become the second leading cause (Rahib L, et al).
• The poor prognosis in PDA is in part due to the limited therapies that are currently available.
• This highlights the importance of high-throughput technologies for gene expression analyses and drug screens.
• A recently developed NanoString Technologies nCounter® analysis system, an example of high-throughput technology, utilizes a color-coded barcode …