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Monitoring Carboplatin Ototoxicity With Distortion-Product Otoacoustic Emissions In Children With Retinoblastoma, Shaum Bhagat, Johnnie Bass, Stephanie White, Ibrahim Qaddoumi, Matthew Wilson, Jianrong Wu, Carlos Rodriguez-Galindo

Faculty Publications

ObjectiveCarboplatin is a common chemotherapy agent with potential ototoxic side effects that is used to treat a variety of pediatric cancers, including retinoblastoma. Retinoblastoma is a malignant tumor of the retina that is usually diagnosed in young children. Distortion-product otoacoustic emission tests offer an effective method of monitoring for ototoxicity in young children. This study was designed to compare measurements of distortion-product otoacoustic emissions obtained before and after several courses of carboplatin chemotherapy in order to examine if (a) mean distortion-product otoacoustic emission levels were significantly different; and (b) if criterion reductions in distortion-product otoacoustic emission levels were observed in …