Medicine and Health Sciences Commons^™

Alterations In Calcium Homeostasis And The Insulin-Like Growth Factor Signaling Pathway Induced By Carcinogenic Polycyclic And Halogenated Aromatic Hydrocarbons In Human Mammary Epithelial Cells, Stacey L. Tannheimer

Pharmaceutical Sciences ETDs

Breast cancer is a major health concern for women, with only a small percent of the risk factors currently identified. It has been estimated that environmental factors may contribute to up to 80% of breast cancer cases. Many environmental carcinogens, such as polycyclic and halogenated aromatic hydrocarbons (PAHs and HAHs), are proven mammary carcinogens in animal models. Therefore, these studies were conducted to elucidate potential roles of PAHs and HAHs in alterations in known signaling pathways in human mammary epithelial cells (HMEC). Carcinogenic PAHs have previously been shown to produce sustained alterations in the calcium (Ca2') homeostasis of lymphocytes Therefore, …

Coping Mechanisms Utilized By Women Survivors Of Breast Cancer, Elizabeth Polk Thomas

MSN Research Projects

The suspected and confirmed diagnosis of breast cancer evokes feelings of fear, anxiety, guilt, frustration, and vulnerability in an individual. A woman diagnosed with breast cancer may utilize a variety of coping mechanisms. This descriptive study sought to identify the most common and most effective coping mechanisms utilized by women survivors of breast cancer answering the following research question: Which coping mechanisms are most effective and most frequently utilized by women survivors of breast cancer? This study used the theory of Lazarus and Folkman (1984) as a framework for understanding coping. The final sample (N = 20) consisted of women …

The Cellular And Molecular Dynamics Of The Queuosine Modification In Transfer Rna: Definition, Modulation, Deficiencies And Effect Of The Queuosine Modification System, Rana C. Morris

Theses and Dissertations in Biomedical Sciences

The presence of the queuosine modification in the wobble position of tRNA^asn, tRN^asp, tRNA^his, and tRNA^tyr is associated with a decrease in cellular growth rate, an increase in the ability to withstand environmental stress, and differentiation of pleuripotent cells into mature phenotypes. The loss of this normal modification is strongly correlated with neoplastic transformation and tumor progression of a wide variety of cancers.

The "normal" system for formation of the queuosine modification in tRNA was studied in human fibroblast cell cultures and in mouse, rat and human liver tissues. The queuosine modification system …

What Is The Intimate Experience Of Couples Following The Woman's Cancer-Related Breast Surgery?, Lynne Amor

Theses: Doctorates and Masters

The purpose of this phenomenological study is to describe and interpret the experience of couples following the woman's surgery for breast cancer, in order to gain an in depth understanding of how this mutilating surgery affects their everyday lives. Breast cancer is the most prevalent form of cancer in Australian women, and in most industrialised nations. Women in Australia have a one in fourteen lifetime risk of developing the disease. Little is known concerning what meanings this surgery brings to the intimacy experienced between partners. It is important to seek knowledge of the phenomenon of intimacy, how the couples understand …