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In Vitro Comparative Studies On The Effect Of Vinblastine Sulfate And Hyperthermia On Normal And Transformed Human Lung Fibroblasts, Fernando Alberto Duk

University of the Pacific Theses and Dissertations

Although the differential response of malignant cells to hyperthermia was observed at the end of the last century, few investigations into the phenomenon were made until fairly recently. At first the results obtained were inconsistent due mostly to the inefficient techniques in use at the time. The advent of cell and tissue culture, increased knowledge in tumor biology, advances in molecular biology, and the development of equipment which could raise and monitor the temperature of tumors during hyperthermic treatments, have made the study of the effects of supranormal temperature on malignant neoplasias substantially more reliable.

The effectiveness of the combined …