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Articles 1 - 8 of 8
Full-Text Articles in Medicine and Health Sciences
A Phenomenological Study Of Faith In Catholic Persons Living With The Diagnosis Of Cancer, Macrina Reyes
A Phenomenological Study Of Faith In Catholic Persons Living With The Diagnosis Of Cancer, Macrina Reyes
Seton Hall University Dissertations and Theses (ETDs)
Background: There were an estimated 1.9 million new cases of cancer diagnosed the United States and over 600,000 deaths from cancer in 2022. Cancer is also known as the 2nd most common cause of death behind heart disease in the US. In 2019, there were an estimated 16.9 million cancer survivors in the US. Furthermore, the number of cancer survivors is expected to increase to 22.2 million by 2030. Unfortunately, the persons' spiritual needs are not being addressed or considered by healthcare practitioners as part of the plan of care, especially Catholics. In order to truly provide person-centered care, healthcare …
Synthesis, Characterization And Biological Evaluation Of Polyarginine Derived Bone-Targeting Peptides, Gina L. Antuono
Synthesis, Characterization And Biological Evaluation Of Polyarginine Derived Bone-Targeting Peptides, Gina L. Antuono
Seton Hall University Dissertations and Theses (ETDs)
Osteoblast-targeting peptides in the treatment of bone disease is a new and novel approach to offering effective treatment of various cancers and can be used in bio-medical, medicinal chemistry and biotechnology applications. By targeting adhesion proteins produced by osteoblast cells, certain cancers which migrate and metastasize to the bone may be more effectively treated. An osteoblast-targeting peptide composed of Ser-Asp-Ser-Ser-Asp (SDSSD) which selectively binds to osteoblast cells via periostin has recently been identified. This peptide was functionalized with polyurethane, generating nanomicelles which encapsulated RNA for the therapeutic treatment of osteoporosis. This study has served as the basis for the research …
Standardized Patient Education For Patients' Initial Chemotherapy Through An Integrated Telemedicine Platform, Karen D. Dougherty
Standardized Patient Education For Patients' Initial Chemotherapy Through An Integrated Telemedicine Platform, Karen D. Dougherty
Seton Hall University Dissertations and Theses (ETDs)
Telemedicine has demonstrated a high level of satisfaction in a variety of health settings as a safe and efficient method of delivering healthcare. The purpose of this project was to implement an Advanced Practice-led Quality Improvement (QI) initiative pilot to evaluate the standardization of chemotherapy education through an integrated telemedicine platform. This Doctor of Nursing Practice (DNP) project used interventions noted in the literature review to assess and evaluate core concepts of knowledge, satisfaction, utilization, and program acceptance. This project aimed to utilize evidence-based processes to increase knowledge about the chemotherapy treatment routine, to raise awareness and develop skills to …
Cancer-Targeting Immunostimulatory Peptides As An Immunotherapeutic Approach To Cancer, Rachel Montel
Cancer-Targeting Immunostimulatory Peptides As An Immunotherapeutic Approach To Cancer, Rachel Montel
Seton Hall University Dissertations and Theses (ETDs)
This dissertation reports the synthesis and biological applications of bifunctional trimeric peptides with B7H6-derived NKp30 binding motifs that serve to activate an immunocytotoxic response in natural killer cells and a GRP78-binding motif that can target tumors that express surface GRP78. In this manner the cancer-targeting immunostimulatory peptides are anticipated to directly bind and activate effector NK92-MI cells while also recognizing and binding to target A549 tumor cells to facilitate NK cell-dependent immunocytotoxicity of the targeted tumors. The NKp30 binding peptide motifs are derived from the tumor associated B7H6 antigen that is often downregulated or shed from the surface of tumors …
B7h6: A Cancer Biomarker For The Development Of Novel Immunotherapy Approaches, Mariana Phillips
B7h6: A Cancer Biomarker For The Development Of Novel Immunotherapy Approaches, Mariana Phillips
Seton Hall University Dissertations and Theses (ETDs)
Cancer-based immunotherapy has led the evolution of biologics that can stimulate immune responses towards tumor eradication. The synthesis of small to intermediate size molecules with the targeting and effector functions of mAb may represent a novel class of immunotherapeutics that may overcome the limitations of their biological counterparts.Towards this objective, B7H6 has been identified as a protein ligand localized on the cell surface of transformed tumor cells. B7H6 binds specifically to the activating receptor NKp30, constitutively expressed on all resting and active NK cells. Upon ligand:receptor binding, B7H6 triggers NK cell activation and release of chemokines and pro-inflammatory cytokines such …
Mental Health Screening Of Veterans Diagnosed With Cancer: Analyzing Psychological Distress And Attitudes Towards Seeking Professional Psychological Help, Jessica Jean Baptiste
Mental Health Screening Of Veterans Diagnosed With Cancer: Analyzing Psychological Distress And Attitudes Towards Seeking Professional Psychological Help, Jessica Jean Baptiste
Seton Hall University Dissertations and Theses (ETDs)
Studies analyzing mental health care utilization in veterans with a co-occurrence of a medical and psychological diagnosis are still underrepresented in the literature. The primary purpose of this study is to examine psychological screening methods of veterans diagnosed with cancer and determining when these veterans are more likely to endorse psychological symptoms. This information can contribute to the discussion of effective ways of integrating mental health screening in specialty care settings. A correlational, causal-comparative research design is employed to answer the study research questions and hypotheses. The participants include Vietnam, Korean, and World War II veterans seeking oncology services at …
Rna Interference Targeting Glucose-Regulated-Protein 78 Induces Hepg2 Cell Apoptosis, Brittany Blackman
Rna Interference Targeting Glucose-Regulated-Protein 78 Induces Hepg2 Cell Apoptosis, Brittany Blackman
Seton Hall University Dissertations and Theses (ETDs)
Cancer is a complex genetic disease that is driven by genetic mutations resulting in chronic, inappropriate cell proliferation. Many current cancer therapies lack specificity towards tumor tissues, ultimately leading to adverse side effects and limited clinical efficacy. Recently, selective cancer cell therapy has examined a well-characterized cell surface marker that is preferentially expressed on tumor cells. The over-expression of an endoplasmic reticulum chaperone protein, 78-kDa glucose-regulated-protein (GRP78), has been observed on the surface of cancer cells, but not on normal tissues. By selectively targeting GRP78 with short-interfering RNA (siRNA), potent GRP78 silencing is anticipated by the RNA interference (RNAi) pathway. …
The Relationship Between Cancer-Related Fatigue And Upper Extremity Function In Breast Cancer Survivors, Meryl Marger Picard
The Relationship Between Cancer-Related Fatigue And Upper Extremity Function In Breast Cancer Survivors, Meryl Marger Picard
Seton Hall University Dissertations and Theses (ETDs)
Background: Cancer-related fatigue (CRF) and arm morbidity constitute the two most common symptom complexes impacting breast cancer survivors (BCS) following surgery and adjuvant treatment, but these multifaceted entities have traditionally been researched as if they were separately occurring events in the survivor’s recovery. Objective: This study examined the relationship between breast cancer survivors’ perceptions of CRF and upper extremity function one to six years post-diagnosis. The study further investigated the impact of multiple adjuvant therapies, node dissection procedures, caring for dependent children, and physical aspects of employment on CRF and upper extremity function. Methods: One hundred fifty-eight BCS responded to …