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An In Vitro Study On The Detection Of Ovarian Cancer Using A Novel Ph-Specific Targeting Polypyrrole Nanocontrasting Agent., Phillip Chuong

College of Arts & Sciences Senior Honors Theses

Longitudinal tracking and accumulation of polymeric nanoparticles in the context of cancer has largely occurred through identification of a fluorescent cargo. In this study, we created a dual extracellular acidic pH targeted polypyrrole-based hollow nanoparticle as a theranostic (maintain both therapeutic and diagnostic capabilities) agent for improved detection and treatment of ovarian cancer. Polypyrrole-hollow nanospheres (PPy-CS) were fabricated through the removal of a silver chloride (AgCl) core, which served as a template, followed by coating with chitosan and further tumor targeted with a pH low insertion peptide, V7. We exploited the NIR-absorbing property of polypyrrole to track both the nanoparticle …