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Articles 1 - 9 of 9
Full-Text Articles in Medicine and Health Sciences
T Cell Therapy: Underlying Mechanisms And Current Advancements, Griffin Mccloy
T Cell Therapy: Underlying Mechanisms And Current Advancements, Griffin Mccloy
Senior Honors Theses
As the second leading cause of death in 2016, cancer is one of the most serious diseases facing the world today. T cell therapy is a current area of research attempting to address the disease with two primary division: CAR-T and TCR-T cell therapy. The immune system naturally produces T lymphocytes to aid in the recognition and removal of cells infected with viruses or transformed into cancer. Under normal circumstances, T lymphocytes identify and destroy cancerous cells; however, some cancerous cell types can evade this system. With the use of genetic editing technology, T lymphocytes can gain the ability to …
The Role Of Mtorc1 In Autophagy As It Relates To Cancer, Olivia Robinson
The Role Of Mtorc1 In Autophagy As It Relates To Cancer, Olivia Robinson
Senior Honors Theses
The mammalian target of rapamycin complex 1, mTORC1, is composed of several subunit proteins with many cellular responsibilities including participation in a complex cell signaling cascade leading to autophagy, which is the regulated degradation of cell components. mTORC1 is frequently mutated or dysregulated within human cancer. Normally, mTORC1 functions to provide efficient regulation of autophagy according to intracellular levels of growth factors, amino acids, nutrients, oxygen levels, and more that can either inhibit mTORC1 and upregulate autophagy or activate mTORC1 and downregulate autophagy. A better understanding of mTORC1 is imperative to preparing cancer therapy treatments. Various cancerous tissue types require …
Spiritual And Religious Interventions For Medically High-Risk Adults: A Systematic Review, Nathanael J. Strissel
Spiritual And Religious Interventions For Medically High-Risk Adults: A Systematic Review, Nathanael J. Strissel
Senior Honors Theses
This systematic review is an update and expansion to the population and methods of a previous systematic review concerning spiritual and religious interventions for the well-being of terminally ill adults. After expanding the criteria to incorporate a more diverse population and including non-randomized experimental studies that contained relatively few concerns of bias, the results of the review are inconclusive due to insufficient data. The lack of usable data in the field highlights the ethical and theoretical issues with the use of experimental trials in analyzing the efficacy of spiritual and religious interventions. The development of spirituality in healthcare will remain …
Genetic Relationships And Therapeutic Options For Relapsed Acute Lymphoblastic Leukemia, Hailie Shertzer
Genetic Relationships And Therapeutic Options For Relapsed Acute Lymphoblastic Leukemia, Hailie Shertzer
Senior Honors Theses
Acute lymphoblastic leukemia (ALL) is the most common form of cancer among children and can be lethal to the adult population. Though 80% of patients with ALL reach complete remission after treatment, about 20% of those diagnosed fail to remain cancer-free. Genetic rearrangements are the hallmark of relapsed ALL, but the mechanism by which these rearrangements occur is still unclear. Recent research suggests these mutations may be detectable during initial diagnosis. If researchers are able to accurately assess the probability of relapse during diagnosis by analyzing the genome of the leukemic cells, the likelihood of administering effective therapy would increase. …
A Literature Review On Intermittent Fasting, Kylie Carrero
A Literature Review On Intermittent Fasting, Kylie Carrero
Senior Honors Theses
Intermittent fasting has been instructed in the Bible as an implied part of daily living. This paper has reviewed the physical benefits of intermittent fasting. In healthy test subjects, it has led to higher levels of autophagy, gut health, and lifespan. In non-healthy test subjects, it has proven beneficial in cancer treatment, as well as in protection against and/or attenuation of the effects of neurodegeneration, metabolic disorders, and cardiovascular diseases. The possible mechanisms underlying these benefits have been discussed in this review.
An Analysis Of Major Issues For Culturally-Minded Professionals In Women's Health Care, Victoria Clark
An Analysis Of Major Issues For Culturally-Minded Professionals In Women's Health Care, Victoria Clark
Senior Honors Theses
Women's health care professionals, such as general physicians, obstetricians and gynecologists, midwives, nurses, and doulas, in the US need to be aware of cultural issues and disparities. Minorities and migrant women experience cultural challenges and disparities when receiving health care in the US. Without cultural sensitivity, patient care is compromised. Pregnancy and childbirth practices vary widely by culture, and potential differences in perspectives, beliefs, and treatment of these are critical issues for women’s health care professionals to study. Female genital cutting (FGC), obstetric fistulas (OF), and female cancer are also discussed in this paper.
Health Effects Of A Vegan Diet And Pediatric Cancer Prevention, Lindsay Wisehart
Health Effects Of A Vegan Diet And Pediatric Cancer Prevention, Lindsay Wisehart
Senior Honors Theses
Veganism is a diet which excludes consumption of all animal products. With proper planning and vitamin supplementation to ensure adequate intake of protein, fat, calcium, zinc, iron, and vitamins D and B12, a vegan diet is widely accepted as suitable for growing and developing children. The decreased levels of dairy, red and processed meats, fat, and protein, and increased levels of fruits and vegetables characteristic of a vegan diet have been shown to reduce risk of mortality and a number of diseases including adult and childhood cancer. Childhood cancer is the second leading cause of childhood death in Western society. …
Pain Interventions In Pediatric Oncology Patients, Allison P. Mcconnell
Pain Interventions In Pediatric Oncology Patients, Allison P. Mcconnell
Senior Honors Theses
Managing pain in the pediatric oncology population can be a daunting task. Often pain in these patients is severe and often not adequately treated or assessed. Studies have found that the reason for this disconnect is due to the impulse to follow unsubstantiated fears and myths held by healthcare professionals and even by the caregivers of the patients. For this reason, many pediatric oncology patients suffer from unnecessary pain when there are both pharmacological and non-pharmacological means available to intervene. The diagnosis and treatment of childhood cancer is multidimensional; however, it can be managed based on recent research and evidence-based …
The Effects Of Vitamin C On Cancer: A Cellular And Epidemiological Perspective, Amy C. Mclaughlin
The Effects Of Vitamin C On Cancer: A Cellular And Epidemiological Perspective, Amy C. Mclaughlin
Senior Honors Theses
While vitamin C has been proven to benefit the immune system during acute infections, there are now many studies to support the findings that vitamin C may also contribute to more effective chemotherapy and lessened damage on the body as a result of chemotherapy. This thesis investigates the impact of vitamin C on many components of cancer such as C-reactive protein, interleukins, reactive oxygen species, and many types of antioxidants and examines vitamin C's ability to inhibit or promote these agents' functions in the body. In addition, this thesis evaluates the ability of vitamin C to keep tumor cells from …