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Articles 1 - 21 of 21
Full-Text Articles in Medicine and Health Sciences
Patient-Centered Communication And Prognosis Discussions With Cancer Patients, Cleveland G. Shields, Casey J. Coker, Shruti S. Poulsen, Jennifer M. Doyle, Kevin Fiscella, Ronald M. Epstein, Jennifer J. Griggs
Patient-Centered Communication And Prognosis Discussions With Cancer Patients, Cleveland G. Shields, Casey J. Coker, Shruti S. Poulsen, Jennifer M. Doyle, Kevin Fiscella, Ronald M. Epstein, Jennifer J. Griggs
Shruti Poulsen
To examine physician communication associated with prognosis discussion with cancer patients.
Targeting Dusps In Glioblastomas–Wielding A Double‐Edged Sword, Sheila Abraham, Swapna Asuthkar, William Lee, Srinivasulu Chigurupat, Andrew Tsung, Kiran Kiran
Targeting Dusps In Glioblastomas–Wielding A Double‐Edged Sword, Sheila Abraham, Swapna Asuthkar, William Lee, Srinivasulu Chigurupat, Andrew Tsung, Kiran Kiran
Sheila Prabhakar Abraham
Several dual-specificity phosphatases (DUSPs) that play key roles in the direct or indirect inactivation of different MAP kinases (MAPKs) have been implicated in human cancers over the past decade. This has led to a growing interest in identifying DUSPs and their specific inhibitors for further testing and validation as therapeutic targets in human cancers. However, the lack of understanding of the complex regulatory mechanisms and cross-talks between MAPK signaling pathways, combined with the fact that DUSPs can act as a double-edged sword in cancer progression, calls for a more careful and thorough investigation. Among the various types of brain cancer, …
Post-Operative Extended Volume External Beam Radiation Therapy In High Risk Esophageal Cancer Patients: A Prospective Experience, E. Yu, P. Tai, J. Younus, R. Malthaner, P. Truong, L. Stitt, G. Rodrigues, R. Ash, R. Dar, B. Yaremko, A. Tomiak, B. Dingle, M. Sanatani, M. Vincent, W. Kocha, D. Fortin, R. Inculet
Post-Operative Extended Volume External Beam Radiation Therapy In High Risk Esophageal Cancer Patients: A Prospective Experience, E. Yu, P. Tai, J. Younus, R. Malthaner, P. Truong, L. Stitt, G. Rodrigues, R. Ash, R. Dar, B. Yaremko, A. Tomiak, B. Dingle, M. Sanatani, M. Vincent, W. Kocha, D. Fortin, R. Inculet
Richard A. Malthaner
Background and purpose: Extended volume external beam radiation therapy (RT) following esophagectomy is controversial. This prospective study evaluates the feasibility of extended volume RT treatment in high-risk esophagectomy patients with cervical anastomosis receiving post–operative combined chemo-radiation therapy. Patients and methods: From 2001-2006, 15 patients with resected esophageal cancer were prospectively accrued to this pilot study, to evaluate the adverse effects of extended volume RT. Eligibility criteria were pathologically proven esophageal malignancy, T3-4, N0-1, disease amenable to surgical resection and esophagectomy with or without resection margin involvement. Patients with distant metastases (M1) and patients treated with previous RT were excluded. All …
Post-Operative Extended Volume External Beam Radiation Therapy In High Risk Esophageal Cancer Patients: A Prospective Experience, E. Yu, P. Tai, J. Younus, R. Malthaner, P. Truong, L. Stitt, G. Rodrigues, R. Ash, R. Dar, B. Yaremko, A. Tomiak, B. Dingle, M. Sanatani, M. Vincent, W. Kocha, D. Fortin, R. Inculet
Post-Operative Extended Volume External Beam Radiation Therapy In High Risk Esophageal Cancer Patients: A Prospective Experience, E. Yu, P. Tai, J. Younus, R. Malthaner, P. Truong, L. Stitt, G. Rodrigues, R. Ash, R. Dar, B. Yaremko, A. Tomiak, B. Dingle, M. Sanatani, M. Vincent, W. Kocha, D. Fortin, R. Inculet
Richard A. Malthaner
Background and purpose: Extended volume external beam radiation therapy (RT) following esophagectomy is controversial. This prospective study evaluates the feasibility of extended volume RT treatment in high-risk esophagectomy patients with cervical anastomosis receiving post–operative combined chemo-radiation therapy. Patients and methods: From 2001-2006, 15 patients with resected esophageal cancer were prospectively accrued to this pilot study, to evaluate the adverse effects of extended volume RT. Eligibility criteria were pathologically proven esophageal malignancy, T3-4, N0-1, disease amenable to surgical resection and esophagectomy with or without resection margin involvement. Patients with distant metastases (M1) and patients treated with previous RT were excluded. All …
Implantable Polymer/Metal Thin Film Structures For The Localized Treatment Of Cancer By Joule Heating, Nima Rahbar, Kwabena Kan-Dapaah, Christian Theriault, Wole Soboyejo
Implantable Polymer/Metal Thin Film Structures For The Localized Treatment Of Cancer By Joule Heating, Nima Rahbar, Kwabena Kan-Dapaah, Christian Theriault, Wole Soboyejo
Nima Rahbar
This paper presents an implantable polymer/metal alloy thin film structure for localized post-operative treatment of breast cancer. A combination of experiments and models is used to study the temperature changes due to Joule heating by patterned metallic thin films embedded in poly-dimethylsiloxane. The heat conduction within the device and the surrounding normal/cancerous breast tissue is modeled with three-dimensional finite element method (FEM). The FEM simulations are used to explore the potential effects of device geometry and Joule heating on the temperature distribution and lesion (thermal dose). The FEM model is validated using a gel model that mimics biological media. The …
Omega-3 Fatty Acids To Augment Cancer Therapy, W. Hardman
Omega-3 Fatty Acids To Augment Cancer Therapy, W. Hardman
Elaine Hardman Ph.D.
The results of animal studies have demonstrated that the consumption of omega-3 fatty acids can slow the growth of cancer xenografts, increase the efficacy of chemotherapy and reduce the side effects of the chemotherapy or of the cancer. Molecular mechanisms postulated to contribute to the multiple benefits of omega-3 fatty acids include 1) suppressing the expression of cyclooxygenase-2 in tumors, thus decreasing proliferation of cancer cells and reducing angiogenesis in the tumor; 2) decreasing the expression of AP-1 and ras, two oncogenes implicated in tumor promotion; 3) inducing differentiation of cancer cells; 4) suppressing nuclear factor--kB activation and bcl-2 expression, …
Examining Cancer And Cardiovascular Risk Behaviours In People Attending Residential Substance Abuse Treatment, Peter Kelly, A Baker, Frances Kay-Lambkin, Frank Deane, Billie Bonevski
Examining Cancer And Cardiovascular Risk Behaviours In People Attending Residential Substance Abuse Treatment, Peter Kelly, A Baker, Frances Kay-Lambkin, Frank Deane, Billie Bonevski
Peter Kelly
No abstract provided.
Review And Critique Of The Quality Of Exercise Recommendations For Cancer Patients And Survivors, Nancy Humpel, Donald Iverson
Review And Critique Of The Quality Of Exercise Recommendations For Cancer Patients And Survivors, Nancy Humpel, Donald Iverson
Don C. Iverson
The benefit of exercise for cancer patients is starting to become recognized. The purposes of this paper were to review the literature to examine whether research findings are being converted into guidelines for patients and survivors and to examine the quality of evidence on which they were based. A computer search of major health databases was conducted for peer-reviewed literature and books on exercise and cancer, and an Internet search was conducted for cancer websites reporting any exercise guidelines/recommendations for cancer patients. Seven peer-reviewed articles, eight books and eight cancer websites were identified that suggested exercise guidelines for cancer patients …
The Danger Of Applying Uniform Clincal Policies Across Populations: The Case Of Breast Cancer In American Indians, Paul Nutting, Ned Calonge, Donald Iverson, Larry Green
The Danger Of Applying Uniform Clincal Policies Across Populations: The Case Of Breast Cancer In American Indians, Paul Nutting, Ned Calonge, Donald Iverson, Larry Green
Don C. Iverson
OBJECTIVES. This study examined the implications of annual screening mammography for cost and mortality in American Indian populations with differing baseline breast cancer rates. METHODS. A decision tree compared annual screening mammography and screening clinical breast examination with referral for diagnostic mammography when appropriate. The decision tree was constructed to examine the effect of different base-line cancer rates, stage at diagnosis, and stage-specific survival. Outcomes included 5-year relative survival, deaths prevented at 5 years, cost per death prevented, and total costs. RESULTS. The findings suggest that the total cost of breast cancer is 3.6 times higher with the screening mammography …
Workgroup Iv: Public Education. Uicc International Workshop On Facilitating Screening For Colorectal Cancer, Oslo, Norway 2002, R Hiatt, J Wardle, S Vernon, J Austoker, L Bistanti, S Fox, R Gnauck, Donald Iverson
Workgroup Iv: Public Education. Uicc International Workshop On Facilitating Screening For Colorectal Cancer, Oslo, Norway 2002, R Hiatt, J Wardle, S Vernon, J Austoker, L Bistanti, S Fox, R Gnauck, Donald Iverson
Don C. Iverson
The Workgroup on public education was brought together to formulate an international perspective on public education for the important public health challenge of increasing colorectal cancer screening. The focus of the group did not include professional education, which is an important channel for public education, since another Workgroup covered that topic. The results of the Workgroup represent an expression of expert opinion and did not include a comprehensive review of the literature. However, the recommendations for further research may stimulate a more in-depth examination of the literature in some areas and generate ideas for investigation.
Involving Providers And Patients In Cancer Control And Prevention Efforts. Barriers To Overcome, Donald Iverson
Involving Providers And Patients In Cancer Control And Prevention Efforts. Barriers To Overcome, Donald Iverson
Don C. Iverson
Although progress has been made in providing cancer prevention and control services to the population, there remain sizeable segments of the population that are either uninvolved or underinvolved with national and state efforts. One method of reaching most of the population, including those segments currently not involved or underinvolved, is through primary care clinicians. Effective, albeit imperfect, strategies to increase the involvement of primary care clinicians in cancer prevention and control are available, and there is emerging evidence that these strategies are making a difference. Unfortunately, the progress made to date is at risk of being lost because of economic …
Feasibility Studies Of Low-Fat Diet To Prevent Or Retard Breast Cancer, P Greenwald, C Clifford, R Butrum, Donald Iverson
Feasibility Studies Of Low-Fat Diet To Prevent Or Retard Breast Cancer, P Greenwald, C Clifford, R Butrum, Donald Iverson
Don C. Iverson
No abstract provided.
Sleep Quality, Fatigue And Physical Activity Following A Cancer Diagnosis, Nancy Humpel, Donald Iverson
Sleep Quality, Fatigue And Physical Activity Following A Cancer Diagnosis, Nancy Humpel, Donald Iverson
Don C. Iverson
Research on physical activity for cancer survivors suggests a relationship with improved quality of life. The aim of this study was to explore if there was also a relationship of physical activity with sleep difficulties and fatigue, common effects of cancer and its treatments. Recruitment was by posters and flyers in medical waiting rooms and by letter of invitation. Thirty-two breast and 59 prostate cancer survivors completed the questionnaire. Poor sleep quality was reported by 57.8%. A greater proportion of breast cancer (36.7%) than prostate cancer survivors (15.5%) reported poor sleep latency, and sleep disturbance (48.4% vs. 17.2%). The mean …
Australian Women's Awareness Of Breast Cancer Symptoms And Responses To Potential Symptoms, Sandra Jones, Parri Gregory, Caroline Nehill, Lance Barrie, Karen Luxford, A. Nelson, Helen Zorbas, Donald Iverson
Australian Women's Awareness Of Breast Cancer Symptoms And Responses To Potential Symptoms, Sandra Jones, Parri Gregory, Caroline Nehill, Lance Barrie, Karen Luxford, A. Nelson, Helen Zorbas, Donald Iverson
Don C. Iverson
Poor awareness of breast cancer symptoms has been associated with patient delay in seeking help; thus reduced survival, more aggressive treatment, and fewer treatment choices. The aim of this study was to develop a representative picture of Australian women’s knowledge of symptoms, experienced potential symptoms, and behavioral responses. A general population sample of approximately 3,000 women aged 30–69 completed a telephone survey; results were compared to previous surveys conducted in 1996 and 2003. The most commonly cited potential symptom of breast cancer was a lump in the breast, identified by 86% of respondents (an increase from 75% in 2003). Other …
Prostate Cancer Screening In The Midst Of Controversy: Canadian Men's Knowledge, Beliefs, Utilization, And Future Intentions, Shawna Mercer, Vivek Goel, Isra Levy, F Ashbury, Donald Iverson, Neill Iscoe
Prostate Cancer Screening In The Midst Of Controversy: Canadian Men's Knowledge, Beliefs, Utilization, And Future Intentions, Shawna Mercer, Vivek Goel, Isra Levy, F Ashbury, Donald Iverson, Neill Iscoe
Don C. Iverson
Despite controversy about prostate cancer screening, administrative data show that the use of prostate specific antigen (PSA) testing in Canada has increased. This study sought to determine awareness and knowledge of prostate cancer and screening, use to date, and future intentions to have a digital rectal examination (DRE) and PSA test among Canadian men aged 40 and over. Data were collected through a Canada-wide cross-sectional random digit dial telephone survey of 629 men. Awareness of DRE and PSA, use to date, and future intended use varied with age and education. Although only 9% of respondents had had PSA testing for …
Defining Research Priorities For Pancreatic Cancer In Australia: Results Of A Consensus Development Process, Monica Robotin, Sandra Jones, Andrew Biankin, Louise Waters, Donald Iverson, Helen Gooden, Bruce Barraclough, Andrew Penman
Defining Research Priorities For Pancreatic Cancer In Australia: Results Of A Consensus Development Process, Monica Robotin, Sandra Jones, Andrew Biankin, Louise Waters, Donald Iverson, Helen Gooden, Bruce Barraclough, Andrew Penman
Don C. Iverson
Introduction: Pancreatic cancer (PC) is the sixth leading cause of cancer death in Australia and the fourth in the United States, yet research in PC is lagging behind that in other cancers associated with a high disease burden. In the absence of agreed processes to reliably identify research areas which can deliver significant advances in PC research, the Cancer Council NSW established a strategic partnership with the NSW Pancreatic Cancer Network to define critical research issues and opportunities that could accelerate progress in this field in Australia. Materials and methods: The process consisted of five distinct stages: a literature review …
A Balancing Act—Telehealth Cancer Genetics And Practitioners’ Experiences Of A Triadic Consultation, Elvira Zilliacus, Bettina Meiser, Elizabeth Lobb, Kristine Barlow-Stewart, Katherine Tucker
A Balancing Act—Telehealth Cancer Genetics And Practitioners’ Experiences Of A Triadic Consultation, Elvira Zilliacus, Bettina Meiser, Elizabeth Lobb, Kristine Barlow-Stewart, Katherine Tucker
Katherine L. Tucker
Telehealth is increasingly used for outreach service in cancer genetic counseling; however what occurs during the consultation and the roles practitioners adopt is largely unknown. Fifteen practitioners participated in semi-structured interviews that explored their roles within telehealth, compared to face-to-face consultations, and the relationship between practitioners during telehealth. As they were not physically present with the patient, most participants felt that telehealth altered the genetic clinician’s role to one of a ‘visiting specialist’. Genetic counselors described undertaking multiple roles during the telehealth process. Two models of interaction were observed. The medical model reduced the interaction to a dyadic consultation by …
Articulating Confocal Endoscope For Imaging Cancers In Vivo, Gary Peterson, Michael Prince, Charles Dimarzio, Frank Dibella, Melind Rajadhyaksha
Articulating Confocal Endoscope For Imaging Cancers In Vivo, Gary Peterson, Michael Prince, Charles Dimarzio, Frank Dibella, Melind Rajadhyaksha
Michael J. Prince
Skin cancers are among the highest incidence cancers, with 1.2 million new cases detected each year in the United States. To detect these new cases, 5.5 million biopsies are performed. Of these 5.5 million biopsies, approximately 4.3 million cases turn out to be normal. These 4.3 million biopsies, which may potentially be avoided, costs US healthcare more than $2 billion every year. Similarly, oral cancers are among the highest incidence cancers worldwide, with an estimated 274,000 new cases detected. Biopsies are invasive, painful, destroy the site under study and leaves scarring. Often, the best areas to biopsy are difficult to …
A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale
A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale
Edward Yu
The focus of this review is on the relationships between autoimmune diseases and cancer from two closely related perspectives: 1.Those autoimmune diseases which are often associated with malignancies. 2.Those prevalent cancers which may increase the risks of developing autoimmune disorders. The review concludes with a brief discussion of some selected innovative approaches to cancer immunotherapy.
Post-Operative Extended Volume External Beam Radiation Therapy In High Risk Esophageal Cancer Patients: A Prospective Experience, E. Yu, P. Tai, J. Younus, R. Malthaner, P. Truong, L. Stitt, G. Rodrigues, R. Ash, R. Dar, B. Yaremko, A. Tomiak, B. Dingle, M. Sanatani, M. Vincent, W. Kocha, D. Fortin, R. Inculet
Post-Operative Extended Volume External Beam Radiation Therapy In High Risk Esophageal Cancer Patients: A Prospective Experience, E. Yu, P. Tai, J. Younus, R. Malthaner, P. Truong, L. Stitt, G. Rodrigues, R. Ash, R. Dar, B. Yaremko, A. Tomiak, B. Dingle, M. Sanatani, M. Vincent, W. Kocha, D. Fortin, R. Inculet
Edward Yu
Background and purpose: Extended volume external beam radiation therapy (RT) following esophagectomy is controversial. This prospective study evaluates the feasibility of extended volume RT treatment in high-risk esophagectomy patients with cervical anastomosis receiving post–operative combined chemo-radiation therapy. Patients and methods: From 2001-2006, 15 patients with resected esophageal cancer were prospectively accrued to this pilot study, to evaluate the adverse effects of extended volume RT. Eligibility criteria were pathologically proven esophageal malignancy, T3-4, N0-1, disease amenable to surgical resection and esophagectomy with or without resection margin involvement. Patients with distant metastases (M1) and patients treated with previous RT were excluded. All …
Infrared Imaging Of The Breast: Initial Reappraisal Using High-Resolution Digital Technology In 100 Successive Cases Of Stage I And Ii Breast Cancer, J. Keyserlingk, P. Ahlgren, E. Yu, N. Belliveau
Infrared Imaging Of The Breast: Initial Reappraisal Using High-Resolution Digital Technology In 100 Successive Cases Of Stage I And Ii Breast Cancer, J. Keyserlingk, P. Ahlgren, E. Yu, N. Belliveau
Edward Yu
There is a general consensus that earlier detection of breast cancer should result in improved survival. Current breast imaging relies primarily on mammography. Despite better equipement and regulation, variability in interpretation and tissue density still affect accuracy. A number of adjuvant imaging techniques are currently being used, including doppler ultrasound and gadolinium-enhanced MRI, which can detect cancer-induced neovascularity. In order to assess the potential contribution of currently available high-resolution digital infrared technology capable of recognizing minute regional vascular flow related temperature variation, we retrospecitively reviewed the relative ability of our preoperative clinical exam, mammography, and infrared imaging to detect 100 …