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Full-Text Articles in Medicine and Health Sciences
Autophagy Modulation And Its Implications On Glioblastoma Treatment, Johnny Chen, Andrea Salinas Rodriguez, Maximiliano Arath Morales, Xiaoqian Fang
Autophagy Modulation And Its Implications On Glioblastoma Treatment, Johnny Chen, Andrea Salinas Rodriguez, Maximiliano Arath Morales, Xiaoqian Fang
School of Medicine Publications and Presentations
Autophagy is a vital cellular process that functions to degrade and recycle damaged organelles into basic metabolites. This allows a cell to adapt to a diverse range of challenging conditions. Autophagy assists in maintaining homeostasis, and it is tightly regulated by the cell. The disruption of autophagy has been associated with many diseases, such as neurodegenerative disorders and cancer. This review will center its discussion on providing an in-depth analysis of the current molecular understanding of autophagy and its relevance to brain tumors. We will delve into the current literature regarding the role of autophagy in glioma pathogenesis by exploring …
Human Macrophages Exhibit Gm-Csf Dependent Restriction Of Mycobacterium Tuberculosis Infection Via Regulating Their Self-Survival, Differentiation And Metabolism, Abhishek Mishra, Vipul K. Singh, Chinnaswamy Jagannath, Margaret Sunitha Selvaraj, Selvakumar Subbian, Blanca I. Restrepo, Marie-Claire Gauduin, Arshad Khan
Human Macrophages Exhibit Gm-Csf Dependent Restriction Of Mycobacterium Tuberculosis Infection Via Regulating Their Self-Survival, Differentiation And Metabolism, Abhishek Mishra, Vipul K. Singh, Chinnaswamy Jagannath, Margaret Sunitha Selvaraj, Selvakumar Subbian, Blanca I. Restrepo, Marie-Claire Gauduin, Arshad Khan
School of Medicine Publications and Presentations
GM-CSF is an important cytokine that regulates the proliferation of monocytes/macrophages and its various functions during health and disease. Although growing evidences support the notion that GM-CSF could play a major role in immunity against tuberculosis (TB) infection, the mechanism of GM-CSF mediated protective effect against TB remains largely unknown. Here in this study we examined the secreted levels of GM-CSF by human macrophages from different donors along with the GM-CSF dependent cellular processes that are critical for control of M. tuberculosis infection. While macrophage of different donors varied in their ability to produce GM-CSF, a significant correlation was observed …
Human Monocyte-Derived Macrophage Responses To M. Tuberculosis Differ By The Host’S Tuberculosis, Diabetes Or Obesity Status, And Are Enhanced By Rapamycin, Blanca I. Restrepo, Arshad Khan, Vipul K. Singh, Erica De Leon, Genesis P. Aguillón-Durán, Eder Ledezma-Campos, David H. Canaday, Chinnaswamy Jagannath
Human Monocyte-Derived Macrophage Responses To M. Tuberculosis Differ By The Host’S Tuberculosis, Diabetes Or Obesity Status, And Are Enhanced By Rapamycin, Blanca I. Restrepo, Arshad Khan, Vipul K. Singh, Erica De Leon, Genesis P. Aguillón-Durán, Eder Ledezma-Campos, David H. Canaday, Chinnaswamy Jagannath
School of Medicine Publications and Presentations
Human macrophages play a major role in controlling tuberculosis (TB), but their anti-mycobacterial mechanisms remain unclear among individuals with metabolic alterations like obesity (TB protective) or diabetes (TB risk). To help discern this, we aimed to: i) Evaluate the impact of the host’s TB status or their comorbidities on the anti-mycobacterial responses of their monocyte-derived macrophages (MDMs), and ii) determine if the autophagy inducer rapamycin, can enhance these responses. We used MDMs from newly diagnosed TB patients, their close contacts and unexposed controls. The MDMs from TB patients had a reduced capacity to activate T cells (surrogate for antigen presentation) …
Cordycepin Inhibits Human Ovarian Cancer By Inducing Autophagy And Apoptosis Through Dickkopf-Related Protein 1/Β-Catenin Signaling, Hyun-Jin Jang, Kyeong Eun Yang, In-Hu Hwang, Yang Hoon Huh, Dae Joon Kim, Hwa-Seung Yoo, Soo Jung Park, Ik-Soon Jang
Cordycepin Inhibits Human Ovarian Cancer By Inducing Autophagy And Apoptosis Through Dickkopf-Related Protein 1/Β-Catenin Signaling, Hyun-Jin Jang, Kyeong Eun Yang, In-Hu Hwang, Yang Hoon Huh, Dae Joon Kim, Hwa-Seung Yoo, Soo Jung Park, Ik-Soon Jang
School of Medicine Publications and Presentations
Cordycepin, the major active component from Cordyceps militaris, has been reported to significantly inhibit some types of cancer; however, its effects on ovarian cancer are still not well understood. In this study, we treated human ovarian cancer cells with different doses of cordycepin and found that it dose-dependently reduced ovarian cancer cell viability, based on Cell counting kit-8 reagent. Immunoblotting showed that cordycepin increased Dickkopf-related protein 1 (Dkk1) levels and inhibited β-catenin signaling. Atg7 knockdown in ovarian cancer cells significantly inhibited cordycepin-induced apoptosis, whereas β-catenin overexpression abolished the effects of cordycepin on cell death and proliferation. Furthermore, we found …