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Full-Text Articles in Medicine and Health Sciences
Regaining Effort-Based Food Motivation: The Drug Methylphenidate Reverses The Depressive Effects Of Tetrabenazine In Female Rats, Deanna Pietrorazio
Regaining Effort-Based Food Motivation: The Drug Methylphenidate Reverses The Depressive Effects Of Tetrabenazine In Female Rats, Deanna Pietrorazio
Honors Scholar Theses
Tetrabenazine (TBZ), a vesicular monoamine transporter type 2 (VMAT-2) inhibitor, depletes dopamine and induces motivational deficits and other depressive symptoms in humans. Methylphenidate (MPH) is a dopamine transport blocker that is used to enhance motivational function. Previous studies have shown that in male rats, TBZ induces a shift in effort-related choice such that a low-effort bias is induced. In male rats this occurs at a dose range of 0.75-1.0 mg/kg TBZ, and this effect is reversible with co-administration of MPH. Recent studies have shown that females need a higher dose of TBZ (2.0 mg/kg) to show the low-effort bias. The …
A Preliminary Investigation On Patterns Of Physical Activity In Cancer Patients Receiving Chemotherapy And Immunotherapy In Relation To Quality Of Life And Depression Rates, Pranav Seshadri
Holster Scholar Projects
Abstract of project: Introduction: Patients undergoing chemotherapy or immunotherapy for cancer tend to remain sedentary following diagnosis. They also suffer from low quality of life (QoL) and increased rates of depression/depressive symptomology. Recent studies indicate that physical activity (PA) may improve QoL and reduce depression rates. The exact patterns of PA in this subject population are unknown. This study investigates patterns of PA in cancer patients receiving treatment to understand how level of PA and types of PA relate to QoL and depressive symptomology. Methods: A cross-sectional survey study was conducted between June and July 2022 at the UConn Health …