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Full-Text Articles in Medicine and Health Sciences
Reinvigorating Immune Response To Advanced Melanoma
Reinvigorating Immune Response To Advanced Melanoma
Thomas Jefferson University Research Magazine
Melanoma represents a small fraction of skin cancerrelated malignancies, yet accounts for the majority of its mortalities—and the incidence of cutaneous melanoma is rising. While treatments using smalltargeted inhibitors and immune checkpoint antibodies have increased long-term survival in advancedstage cutaneous melanoma, many patients still do not realize any benefit from the treatments. Another group of patients initially have beneficial results but ultimately find their disease progressing, in part due to cancer cells’ acquired resistance to immune response. And still other patients have difficulty with the treatment’s high toxicity.
Emad Alnemri, PhD, Thomas Eakins Professor of Biochemistry and Molecular Biology, and …
Striving To Understand Disparities In Cancer Care
Striving To Understand Disparities In Cancer Care
Thomas Jefferson University Research Magazine
A key element of the mission of the Sidney Kimmel Cancer Center–Jefferson Health—and an objective of many researchers across the University—is to understand and mitigate the disparities in cancer incidence, treatment and outcome too often experienced by patients who are African American or Latinx, have low incomes or have limited access to care.
In the Philadelphia region, for example, prostate cancer incidence and mortality rates are significantly higher for African Americans than Caucasians, but the causes of this major disparity are unknown. Many researchers have believed that the difference in outcomes results from African American men’s poor clinical response to …