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2022

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Full-Text Articles in Medicine and Health Sciences

Prevalence And Evaluation Of Multidrug Resistance Pattern Of Pseudomonas Aeruginosa Among Critical And Non-Critical Areas At A Tertiary Care Hospital Of Multan, Romah Ishfaq, Hubza Ruatt Khan, Mehvish Javeed, Muhammad Ikrama Tanveer, Asma Ashraf Dec 2022

Prevalence And Evaluation Of Multidrug Resistance Pattern Of Pseudomonas Aeruginosa Among Critical And Non-Critical Areas At A Tertiary Care Hospital Of Multan, Romah Ishfaq, Hubza Ruatt Khan, Mehvish Javeed, Muhammad Ikrama Tanveer, Asma Ashraf

Journal of Bioresource Management

Pseudomonas aeruginosa is an extremely wide spread microorganism linked to nosocomial illnesses. Effective inspection of variations in antimicrobial resistance patterns of P. aeruginosa is vital for selecting suitable antimicrobial drugs for pragmatic treatment. The current research has been performed for assessing antimicrobial sensitivity profile of P. aeruginosa isolated as of a variety of medical specimens collected from critical and non-critical admitted patients of Nishtar Hospital, Multan. The isolates were detected utilizing standard lab practices, as well as the sensitivity was examined employing Kirby-Bauer disk diffusion method corresponding to Clinical and Laboratory Standard Institute (CLSI) recommendations 2019. Out of 373 samples, …


Risk Factors For Emergency Medical Care Or Hospitalization Due To Heat-Related Illness Or Injury: A Systematic Review, Blair Litwiller, Amber N. Barnes Dec 2022

Risk Factors For Emergency Medical Care Or Hospitalization Due To Heat-Related Illness Or Injury: A Systematic Review, Blair Litwiller, Amber N. Barnes

Florida Public Health Review

Background: Temperatures globally have been predicted to increase due to changes in the climate. As the earth gets warmer, it is expected that heat-related illness will also increase worldwide. An effective and appropriate public health response will be critical. Purpose: The aim of this review was to identify risk factors associated with heat-related illness and injury to provide target areas for future interventions. Methods: A review of existing literature was analyzed for risk factors that may increase the likelihood of being admitted to an emergency department for a heat related illness or injury. Results: Of the …


The Acute Effects Of Talocrural Mwm Compared With The Application Of Soft-Tissue Of The Plantarfascia On Chronic Lateral Ankle Sprains For Ankle Dorsiflexion R.O.M., Peter Hempenstall, Brian O'Rourke Dec 2022

The Acute Effects Of Talocrural Mwm Compared With The Application Of Soft-Tissue Of The Plantarfascia On Chronic Lateral Ankle Sprains For Ankle Dorsiflexion R.O.M., Peter Hempenstall, Brian O'Rourke

SURE Journal: Science Undergraduate Research Experience Journal

Previous research has looked at various treatment remedies for improving acute ankle Dorsiflexion Range of Motion (DFROM) post chronic Lateral Ankle Sprain (LAS). Mulligan’s Mobilisation with Movement (MWM) appears frequently however, the significance and mechanism remain quite conflicting (Gilbreath et al., 2015). It is also known that after a LAS, the Lateral Ligament Complex (LLC) is compromised and the calcaneus inverts, increasing stiffness of plantarfascia (Al-Mohrej & Al-Kenani, 2016, Denegar et al., 2002, Loudon & Bell, 1996). The objective of this study was to further explore the effectiveness of MWM compared with soft-tissue (ST) application of the plantarfascia on acute …


Therapies For Mitochondrial Disorders, Kayli Sousa Smyth, Anne Mulvihill Dec 2022

Therapies For Mitochondrial Disorders, Kayli Sousa Smyth, Anne Mulvihill

SURE Journal: Science Undergraduate Research Experience Journal

Mitochondria are cytoplasmic, double-membrane organelles that synthesise adenosine triphosphate (ATP). Mitochondria contain their own genome, mitochondrial DNA (mtDNA), which is maternally inherited from the oocyte. Mitochondrial proteins are encoded by either nuclear DNA (nDNA) or mtDNA, and both code for proteins forming the mitochondrial oxidative phosphorylation (OXPHOS) complexes of the respiratory chain. These complexes form a chain that allows the passage of electrons down the electron transport chain (ETC) through a proton motive force, creating ATP from adenosine diphosphate (ADP). This study aims to explore current and prospective therapies for mitochondrial disorders (MTDS). MTDS are clinical syndromes coupled with abnormalities …


Anthelmintic Resistance In Sheep Across Ireland And The Uk: A Literature Review Of The In Vivo Versus In Vitro Methods, Megan Tumulty Dec 2022

Anthelmintic Resistance In Sheep Across Ireland And The Uk: A Literature Review Of The In Vivo Versus In Vitro Methods, Megan Tumulty

SURE Journal: Science Undergraduate Research Experience Journal

Background: The animal welfare and production consequences of gastrointestinal nematode infections, namely Nematodirus battus, on sheep are compelling. The control of gastrointestinal infections has been heavily reliant on the administration of anthelmintics since their introduction into mainstream use in 1960. However, their frequent and often excessive use has resulted in anthelmintic resistance being reported extensively in several gastrointestinal nematode species. The prevalence of anthelmintic resistance as well as the increase in the number of cases of multiple-drug resistance in nematode populations now poses substantial hindrance on the viability of sheep production systems. However, despite the threat N. battus poses …


Doctoral Studies As Learning To Rename The World, Hyleen Mariaye Dec 2022

Doctoral Studies As Learning To Rename The World, Hyleen Mariaye

Journal of Multicultural Affairs

The reflective experience documented in this paper engages with doctoral learning from Freire’s (1968/2000) conceptual lens of naming the world. Written from the narrative lens of the supervisor, it considers how doctoral level studies in education can position both the supervisor and the candidates as agents actively reconstructing their understanding of the world and their place in it. The doctoral journey is viewed as praxis compelling researchers to expand their frames for reading the world, accommodating the other, including multiple voices and thus demonstrating commitment to a global and yet constantly contested notion of citizenship.


Poetry And Praxis: Lessons From An Activist Educator, Dr. Emmanuel Tabi Dec 2022

Poetry And Praxis: Lessons From An Activist Educator, Dr. Emmanuel Tabi

Journal of Multicultural Affairs

Drawing on data from a narrative multi-case study based in Toronto, Canada, this article discusses the lived experiences of one Black activist. Utilizing critical race theory, new literacy studies and the rhetoric of cultural production as theoretical frameworks, the article foregrounds the work of Ebele, a Toronto activist whose work supported the educational trajectories and emotional well-being of Black students, many of whom reported being marginalized in school. Through his creative labor, Ebele directly addressed the sociology of anti-Black racism that deeply influences the lives of Afrodiasporic people in Canada. This article continues the conversation about what it means to …


Does The Anastatica Hierochuntica Plant Shorten The Duration Of Labour? A Prospective Observational Study, Filiz Okumuş, Halime Öncü-Çelik, Nevin Şahin Dec 2022

Does The Anastatica Hierochuntica Plant Shorten The Duration Of Labour? A Prospective Observational Study, Filiz Okumuş, Halime Öncü-Çelik, Nevin Şahin

Journal of Asian Midwives (JAM)

Objective: This study aims to investigate the effect of Anastatica Hierochuntica L. on the duration of labour in primiparous women.
Methods: A prospective, case-controlled study with an intervention (n=28) and control (n=29) group. Participants were not randomized; their preferences related to the use of the A. Hierochuntica L. determined the group in which they would be included. In the intervention group, Anastatica Hierochuntica L. was used by all women. Standard care continued for both the intervention and control group. The duration of the first and second stage of labour were evaluated and compared between groups.
Results: Participants’ mean of age …


Potential Risks Inherent In Robotic Process Automation, Colin L. Robinson, David Y. Chan Dec 2022

Potential Risks Inherent In Robotic Process Automation, Colin L. Robinson, David Y. Chan

Journal of Vincentian Social Action

Robotic process automation (RPA) uses automation technologies to perform tasks typically performed by humans. Although such technology has been instrumental in expediting business operations and lowering costs, it has also created several risks that warrant scrutiny. When discussing the drawbacks of automation, many will point to the number of jobs lost to the influx of automation. However, there are technology risks that organizations must consider such as fraud and cybersecurity. Fraudsters may utilize RPA to commit more novel and subtle technological and cyber security fraud. Organizations may implement internal control measures to prevent or mitigate such schemes, segregation of duties, …


Consumer Boycotts In The Time Of War Crisis: An Efficient Citizenship Strategy Or A Temporary Spurt Of Solidarity, Jolanta Zralek Dec 2022

Consumer Boycotts In The Time Of War Crisis: An Efficient Citizenship Strategy Or A Temporary Spurt Of Solidarity, Jolanta Zralek

Journal of Vincentian Social Action

By drawing from the theory of consumer citizenship, collective activism, and consumer boycotts, this article strives to understand the nature of the current calls for consumer resistance and the following consumers’ actions that resulted from the Russian invasion of Ukraine. In particular, by utilizing Friedman’s (1991) taxonomy of boycotts, we aimed to identify the character, motives, and tools of ongoing boycotts and thus estimated their actual and probable effectiveness. The main research questions in this paper concern what type of consumer boycotts we currently observe, what the aims and motives are of current boycotting, and whether the noticed boycotting attempts …


Leveraging Next-Gen Technology For Supply Chain Security, Thomas Drape, Reginald P. Parker Dec 2022

Leveraging Next-Gen Technology For Supply Chain Security, Thomas Drape, Reginald P. Parker

Journal of Vincentian Social Action

Global supply chain disruptions continue as part of both a national and global discussion. There is a need for a greater focus on supply chain security as part of this discussion as there is an increasing amount of counterfeit parts and goods within global supply chains. While counterfeit activity is an economic burden to companies and the global market, there are also legitimate concerns on consumer safety, consumer trust and company brand management.

The aim for this paper is to identify the concern and extent of the counterfeit problem and identify the use of next-gen technologies to provide brand protection …


Sustainability Across The Supply Chain: A Case Study In The Automotive Industry, Jane Siegler, Angelyn Bidlack, Sarah Harrison Dec 2022

Sustainability Across The Supply Chain: A Case Study In The Automotive Industry, Jane Siegler, Angelyn Bidlack, Sarah Harrison

Journal of Vincentian Social Action

The United Nations Sustainable Development Goals have been widely adopted and implemented by organizations worldwide. However, with 17 goals and 169 targets, the decision on what to focus on and invest in are not trivial tasks. This research focuses on a major Tier-1 automotive supplier, here identified as CMF. With annual sales of 16 billion euros (2021), one in every three vehicles in the world is equipped with some form of CMF technology. The objective of this research was to evaluate CMF’s value chain and understand the challenges and opportunities related to the United Nations 17 Sustainability Development Goals (SDGs). …


Covid-19 And Culture: Individualism Versus Collectivism, Short-Term Versus Long-Term Orientation, And Indulgence Versus Restraint, Charles Lanier, Navpreet Pooni Dec 2022

Covid-19 And Culture: Individualism Versus Collectivism, Short-Term Versus Long-Term Orientation, And Indulgence Versus Restraint, Charles Lanier, Navpreet Pooni

Journal of Vincentian Social Action

To some degree, all social behaviors may be affected by cultural influences. So which national cultures could be positive influences or negative influences on the prevention of a contagion? (Roser et al., 2020). This paper explores regression models for predicting initial Covid-19 cases per capita by country utilizing only Hofstede’s six Cultural Dimensions (Hofstede et al., 2010).

Regression techniques were applied to develop predictive models for initial Covid-19 rates. Two proposed models were found that explained 54% and 60% of the variability in numbers of initial Covid-19 cases by country: The first model included only Individualism, and the second included …


Study Of The Impact Of Working At Home And The Fears Of Returning To Work Among Managers And Professionals Who Are In Virtual Congruent Jobs And Who Are High Growth/Achievement Oriented, Carmine Gibaldi, Gerald Cusack, Niall Hegarty Dec 2022

Study Of The Impact Of Working At Home And The Fears Of Returning To Work Among Managers And Professionals Who Are In Virtual Congruent Jobs And Who Are High Growth/Achievement Oriented, Carmine Gibaldi, Gerald Cusack, Niall Hegarty

Journal of Vincentian Social Action

Using two surveys, this article examines employee opinions on working from home during the Covid-19 pandemic. In March 2020 we chronicled the experience and reactions of 478 managers and professionals to the mandate they work at home. We found that a large portion of the respondents felt no significant loss in productivity and no reduction in job satisfaction. Most of the challenges they faced had involved efforts required to establish a facilitating home working environment and disruptions in the ease of collaboration with others. The opportunities overwhelmingly focused on the benefits of having more time to rebalance their work and …


Economic Implications Of State-Wide Covid-19 Response Aggressiveness, Bryan Foltice, Michael Edward Parker Dec 2022

Economic Implications Of State-Wide Covid-19 Response Aggressiveness, Bryan Foltice, Michael Edward Parker

Journal of Vincentian Social Action

This paper aims to evaluate how the aggressiveness of each state’s response to the Covid-19 pandemic affected their respective economies from Q2, 2020 through Q2, 2021. In our study, we utilize the scale developed by McCann (2021, April 6), which ranks the least aggressive state response to the most aggressive state response at three different points of the pandemic. Through this methodology, we test the impact of the aggressiveness of each state governments’ response with the resulting economic impact within that state. Namely, we examine how this level of response affected each state’s unemployment rate, gross domestic product growth, and …


Building A Better Future: Restoration, Resilience, And Sustainability, Biagio Pilato, Igor Tomic Dec 2022

Building A Better Future: Restoration, Resilience, And Sustainability, Biagio Pilato, Igor Tomic

Journal of Vincentian Social Action

No abstract provided.


Toc Dec 2022

Toc

Journal of Vincentian Social Action

No abstract provided.


Editors Dec 2022

Editors

Journal of Vincentian Social Action

No abstract provided.


Cover Dec 2022

Cover

Journal of Vincentian Social Action

No abstract provided.


Comparison Of Supine And Vertical Bioimpedance Measurements In Young Adults, Jeremy B. Ducharme, Chloe Clark, Jonathan M. Houck, Holly Hall, Avadney Gerard-Osbourne, Ann Gibson Dec 2022

Comparison Of Supine And Vertical Bioimpedance Measurements In Young Adults, Jeremy B. Ducharme, Chloe Clark, Jonathan M. Houck, Holly Hall, Avadney Gerard-Osbourne, Ann Gibson

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 3: Issue 1, Article 11, 2022. Bioelectrical impedance analysis (BIA) methods estimate health parameters such as phase angle (PhA) and body fat percentage (%BF) from various positional and electrode configurations. PhA and %BF are known biological markers of cellular and physical health, respectively, and can be used to predict various health-related conditions and therefore require accurate assessment. The purpose of this study was to evaluate the effect of body position during BIA by investigating the difference and agreement between PhA and %BF using RJL (supine) and InBody (vertical) analyzers. Thirty-eight young adults (23.4 …


Healthfulness Of Fast-Food And Full-Service Restaurants In 16 Georgia Counties After Mandatory Menu Labeling, Janani Rajbhandari-Thapa, Donglan Zhang, Nicole Katapodis, Dana Alvin, Melanie Andrews Dec 2022

Healthfulness Of Fast-Food And Full-Service Restaurants In 16 Georgia Counties After Mandatory Menu Labeling, Janani Rajbhandari-Thapa, Donglan Zhang, Nicole Katapodis, Dana Alvin, Melanie Andrews

Journal of the Georgia Public Health Association

Background: Despite that the effect of menu labeling on consumer choices has been studied, there are gaps in the research on the healthfulness of the restaurant food environment post-mandatory menu labeling, specifically in the Southern United States. This study aims to assess the healthfulness of fast-food and full-service chain restaurant environments after compliance with mandatory menu labeling.

Methods: The healthfulness of 46 representative fast-food and full-service chain restaurants in 16 Georgia counties was examined using the Nutritional Environment Measures in Restaurants (NEMS-R) survey. The scores were compared between full-service and fast-food restaurants using t-tests across several healthfulness measures such as …


Cervical Muscle Strength And Kinematics During An Unanticipated Perturbation In University Aged Male And Female Rugby Athletes, Abigail Ruppert, Lauren J. Lattimer Dec 2022

Cervical Muscle Strength And Kinematics During An Unanticipated Perturbation In University Aged Male And Female Rugby Athletes, Abigail Ruppert, Lauren J. Lattimer

Journal for Sports Neuroscience

Introduction: Female athletes participating in contact sports demonstrate a concussion injury risk factor that is two times greater than their age-matched male counterparts. Recent literature has outlined the importance of neck muscle strength and neuromuscular characteristics in the mitigation of excessive head kinematics. Rugby is a contact sport in which tackles comprise the mechanism for concussion, which is caused by inertial impacts. Females exhibit higher measurements of acceleration and investigating potential gender differences in dynamic stabilization of the head is warranted in rugby. Methods: Twenty-three (15 female, 8 male) university-aged rugby athletes participated in kinematic analysis; and a series of …


Full Issue, Volume 10, Number 3, Journal Of Human Sciences And Extension Dec 2022

Full Issue, Volume 10, Number 3, Journal Of Human Sciences And Extension

Journal of Human Sciences and Extension

No abstract provided.


Traditional And Virtual Hypertension Self-Management Health Education Program Delivered Through Cooperative Extension, Michelle Parisi, Ellie Lane, Cheryl J. Dye Dr., Rhonda Matthews, Danielle Mcfall, Ethan Bain, Windsor W. Sherrill Dec 2022

Traditional And Virtual Hypertension Self-Management Health Education Program Delivered Through Cooperative Extension, Michelle Parisi, Ellie Lane, Cheryl J. Dye Dr., Rhonda Matthews, Danielle Mcfall, Ethan Bain, Windsor W. Sherrill

Journal of Human Sciences and Extension

Fewer than 25% of individuals in the United States with hypertension have controlled blood pressure (Centers for Disease Control and Prevention, 2021). Hypertension Management Program (HMP) adopted the Health Coaches for Hypertension Control© (HCHC©) curriculum and adapted it for delivery by Extension agents. Eight lessons with intermittent health coaching calls were delivered. Pre/post-participation surveys determined changes in knowledge and self-reported weight, systolic (SBP), and diastolic blood pressure (DBP). The pandemic forced a shift in methodology from in-person to virtual delivery, and results were compared. In both traditional and virtual programs, significant differences were found in weight, knowledge …


The Expression Of Acat1 In Oral Squamous Cell Carcinoma And The Adjacent Pre-Tumour Tissue, Hadis Firouzpour, Seyed Mohammad Shokrolahi, Ekaterina Bourova-Flin, Samira Derakhshan, Zahra Shahsavari, Abbas Karimi, Hassan Mir Mohammad Sadeghi, Afsaneh Goudarzi Nov 2022

The Expression Of Acat1 In Oral Squamous Cell Carcinoma And The Adjacent Pre-Tumour Tissue, Hadis Firouzpour, Seyed Mohammad Shokrolahi, Ekaterina Bourova-Flin, Samira Derakhshan, Zahra Shahsavari, Abbas Karimi, Hassan Mir Mohammad Sadeghi, Afsaneh Goudarzi

BioMedicine

Background: Altered acetyl CoA acetyltransferase 1 (ACAT1) expression has been reported in diverse cancers. However, the expression of ACAT1 and its prognostic value in oral squamous cell carcinoma (OSCC) has remained unexplored. Materials and methods: In this study, the expression of ACAT1 was analysed by immunohistochemistry (IHC) in 61 OSCC patients and compared between OSCC and adjacent pre-tumour tissue of 21 patients. Results: The expression of ACAT1 in OSCC tumours is heterogeneous between patients. More specifically, 52.38% of the patients show low expression of ACAT1 in both tumour and adjacent pre-tumour tissues, 9.52% of the patients show high expression of …


The Effect Of Ghrelin On Antioxidant Status In The Rat’S Model Of Alzheimer's Disease Induced By Amyloid-Beta, Fatemeh Sarlaki, Zahra Shahsavari, Fatemeh Goshadrou, Faezeh Naseri, Mohammad Keimasi, Majid Sirati-Sabet Dr Nov 2022

The Effect Of Ghrelin On Antioxidant Status In The Rat’S Model Of Alzheimer's Disease Induced By Amyloid-Beta, Fatemeh Sarlaki, Zahra Shahsavari, Fatemeh Goshadrou, Faezeh Naseri, Mohammad Keimasi, Majid Sirati-Sabet Dr

BioMedicine

Alzheimer's disease (AD) is a neurodegenerative disorder associated with amyloid-beta (Aβ) plaque formation and oxidative stress in the brain. Ghrelin has been proven to exert antioxidant activity and neuroprotection in different neurological diseases. This study is going on to examine the effect of ghrelin on antioxidant status in the rat’s model of AD induced by Aβ. Cognitive impairment was induced by intra-hippocampal administration of Aβ (10 µg) in Wistar rats and ghrelin (80 μg/kg) was administrated intraperitoneal for ten consecutive days. Behavior was assessed with Morris water maze and passive avoidance tests. Malondialdehyde (MDA) level as a marker of lipid …


Clinicopathological And Prognostic Significance Of Cxcr4 Expression In Osteosarcoma: A Meta-Analysis, I Gusti Ngurah Ananda Wira Kusuma, Grace Yulia Alphani Yapson, John Nolan, I Gede Eka Wiratnaya, I Gede Putu Supadmanaba Nov 2022

Clinicopathological And Prognostic Significance Of Cxcr4 Expression In Osteosarcoma: A Meta-Analysis, I Gusti Ngurah Ananda Wira Kusuma, Grace Yulia Alphani Yapson, John Nolan, I Gede Eka Wiratnaya, I Gede Putu Supadmanaba

BioMedicine

Background: The C-X-C Motif Chemokine Receptor (CXCR4) is an oncogene that has been widely studied and associated with worse clinicopathological features and prognosis outcomes in many types of cancer. Besides that, significance of CXCR4 expression on clinicopathological features and prognostic factors in osteosarcoma (OS) requires further validation.

Aim: We conducted a meta-analysis to evaluate the association between positive CXCR4 expression with clinicopathological features and prognosis in OS.

Methods: Literature searches on Pubmed, Cochrane Library, and Web of Science were conducted systematically up to December 2021 to find relevant references. The effects of CXCR4 expression on clinicopathological characteristics and prognostic were …


Analysis Of Antiquorum-Sensing And Antibiofilm Activity By Pomelo Peel Extract (Citrus Maxima) On Multidrug-Resistance Pseudomonas Aeruginosa, I Gede Krisna Arim Sadeva, Putri Ayu Wulandari, Aizar Vesa Prasetyo, Luh Putu Nike Wahyuntika, Putu Nindya Krisnadewi Rahadi, I Gede Aswin Parisya Sasmana, I Made Rhamandana Putra, Agus Eka Darwinata Nov 2022

Analysis Of Antiquorum-Sensing And Antibiofilm Activity By Pomelo Peel Extract (Citrus Maxima) On Multidrug-Resistance Pseudomonas Aeruginosa, I Gede Krisna Arim Sadeva, Putri Ayu Wulandari, Aizar Vesa Prasetyo, Luh Putu Nike Wahyuntika, Putu Nindya Krisnadewi Rahadi, I Gede Aswin Parisya Sasmana, I Made Rhamandana Putra, Agus Eka Darwinata

BioMedicine

Pseudomonas aeruginosa is gram-negative bacteria with high adaptability by forming biofilms and quorum-sensing mechanisms to avoid immune responses and antimicrobial agents which tend to develop into Multidrug Resistance (MDR) related to Healthcare-Associated Infection (HAI) with a prevalence of 3,8% in Indonesia and a mortality of up to 69%. Polyphenol compounds found in pomelo peels (Citrus maxima) have been shown to have antibiofilm and antiquorum-sensing effects but are less investigated. Therefore, this study aimed to investigate those effects on MDR P. aeruginosa. In vitro study design is performed to evaluate the inhibition effect of ethanolic extract on bacterial …


Crosstalk Between Fatty Acid Metabolism And Tumour-Associated Macrophages In Cancer Progression, Noorzaileen Eileena Zaidi, Nur Aima Hafiza Shazali, Thean Chor Leow, Mohd Azuraidi Osman, Kamariah Ibrahim, Nik Mohd Afizan Nik Abd Rahman Nov 2022

Crosstalk Between Fatty Acid Metabolism And Tumour-Associated Macrophages In Cancer Progression, Noorzaileen Eileena Zaidi, Nur Aima Hafiza Shazali, Thean Chor Leow, Mohd Azuraidi Osman, Kamariah Ibrahim, Nik Mohd Afizan Nik Abd Rahman

BioMedicine

Over the last few decades, cancer has been regarded as an independent and selfsustaining progression. The earliest hallmarks of cancer comprise of sustaining proliferative signalling, avoiding growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Nonetheless, two emerging hallmarks are being described: aberrant metabolic pathways and evasion of immune destruction. Changes in tumour cell metabolism are not restricted to tumour cells alone; the products of the altered metabolism have a direct impact on the activity of immune cells inside the tumour microenvironment, particularly tumour-associated macrophages (TAMs). The complicated process of cancer growth is orchestrated …


Is Autologous Platelet Activation The Key Step In Ovarian Therapy For Fertility Recovery And Menopause Reversal?, Natalie S. Rickers, E. Scott Sills Nov 2022

Is Autologous Platelet Activation The Key Step In Ovarian Therapy For Fertility Recovery And Menopause Reversal?, Natalie S. Rickers, E. Scott Sills

BioMedicine

Platelets are a uniquely mammalian physiologic feature. As the only non-marine vertebrates to experience menopause, humans have a substantial post-reproductive lifespan and are believed to have a limited, non-renewable oocyte supply. Ovarian reserve typically declines after about age 35yrs, marking losses which cannot be recovered by available fertility medications. When in vitro fertilization fails due to low or absent ovarian response, gonadotropin adjustments are often ineffectual and if additional oocytes are occasionally harvested, egg quality is usually poor. This problem was confronted by Greek researchers who developed a new surgical method to insert autologous platelet-rich plasma (PRP) into ovaries; the …