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Full-Text Articles in Medicine and Health Sciences
The Global Burden Of Cancer Attributable To Risk Factors, 2010–19: A Systematic Analysis For The Global Burden Of Disease Study 2019, Gbd 2019 Cancer Risk Factors Collaborators, Ali Artaman
The Global Burden Of Cancer Attributable To Risk Factors, 2010–19: A Systematic Analysis For The Global Burden Of Disease Study 2019, Gbd 2019 Cancer Risk Factors Collaborators, Ali Artaman
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Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk–outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in …
A Narrative Review Of The Evidence For Variations In Serum 25-Hydroxyvitamin D Concentration Thresholds For Optimal Health, William B. Grant, Fatme Al Anouti, Barbara J. Boucher, Erdinç Dursun, Duygu Gezen-Ak, Edward B. Jude, Tatiana Karonova, Pawel Pludowski
A Narrative Review Of The Evidence For Variations In Serum 25-Hydroxyvitamin D Concentration Thresholds For Optimal Health, William B. Grant, Fatme Al Anouti, Barbara J. Boucher, Erdinç Dursun, Duygu Gezen-Ak, Edward B. Jude, Tatiana Karonova, Pawel Pludowski
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Vitamin D3 has many important health benefits. Unfortunately, these benefits are not widely known among health care personnel and the general public. As a result, most of the world’s population has serum 25-hydroxyvitamin D (25(OH)D) concentrations far below optimal values. This narrative review examines the evidence for the major causes of death including cardiovascular disease, hypertension, cancer, type 2 diabetes mellitus, and COVID-19 with regard to sub-optimal 25(OH)D concentrations. Evidence for the beneficial effects comes from a variety of approaches including ecological and observational studies, studies of mechanisms, and Mendelian randomization studies. Although randomized controlled trials (RCTs) are generally considered …