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Articles 1 - 12 of 12
Full-Text Articles in Medicine and Health Sciences
Automatic Data Collection System And Video Laryngoscope Database, Gabrielle Hoyer
Automatic Data Collection System And Video Laryngoscope Database, Gabrielle Hoyer
Utah Space Grant Consortium
The aggregate intubation data collected by a network of video laryngoscopes can be processed to understand the quality of an individual’s or a group of individual’s practice(s). Currently, all data surrounding intubations is self-reported and not understood on an aggregate basis. We are developing a technology which can enable monitoring and benchmarking of intubations across a wide variety of practices.
Predicting Propofol-Induced Burst Suppression Using An Individualized Model-Based Approach Over Repeated Treatments, Jason C. Huang
Predicting Propofol-Induced Burst Suppression Using An Individualized Model-Based Approach Over Repeated Treatments, Jason C. Huang
Utah Space Grant Consortium
Our group is investigating the antidepressant effects of high-dose propofol, but dosing propofol to induce standardized changes in EEG activity (“burst suppression”) is challenging due to limited knowledge of each subject’s pharmacokinetics (PK) and pharmacodynamics (PD). In this paper, we approximated PK-PD models for propofol-induced burst suppression (PIBS), based on multiple subjects over repeated treatments. We then applied these models to predict BSR in each subject’s repeated treatment, then evaluate their predictive performances. We hypothesized that predicting BSR from a greater number of previous treatments would improve performance, but our current results are not conclusive enough to validate the hypothesis. …
Monitoring Acute Kidney Injury Risk With Urine Oxygen Partial Pressure, Lars Lofgren
Monitoring Acute Kidney Injury Risk With Urine Oxygen Partial Pressure, Lars Lofgren
Utah Space Grant Consortium
Acute kidney injury (AKI) is a common complication associated with cardiac surgery. AKI is associated with increased hospital costs, hospital length of stay (LOS), and mortality risk. The current diagnostic criteria rely on serum creatinine measurements and urine output data. Serum creatinine is not renal specific. It is known that there are factors other than renal injury that influence serum creatine concentrations. Serum creatinine levels are measured as concentrations which means large changes in fluid balance may alter the serum creatinine concentration. Urine output is not a reliable measurement of renal injury, either. During surgery it is common to administer …
Detecting Dna Oxidation In Sperm, Alexie Zwerdling
Detecting Dna Oxidation In Sperm, Alexie Zwerdling
Student Research Symposium
Declining body-wide levels of nicotinamide adenine dinucleotide (NAD) that are present in normal aging men are linked to decreased sperm quality and DNA integrity. When NAD is low, the amount of oxidative stress on the DNA appears to be increased, due to the limited regeneration of the antioxidant glutathione, which is NAD-dependent. We therefore hypothesize that the increased sperm DNA damage in the aging male is caused by an elevated formation of 8-oxoguanine in the DNA, caused by increased oxidative stress when NAD levels are low. To test this hypothesis, a transgenic mouse model (ANDY mouse) was used to create …
Using Handmade Cloning To Reduce Oocyte Mitochondria In Reconstructed Embryos, Laura Adams
Using Handmade Cloning To Reduce Oocyte Mitochondria In Reconstructed Embryos, Laura Adams
Student Research Symposium
Mitochondrial heteroplasmy, the presence of more than one population of mitochondrial DNA (mtDNA) in one cell, can cause metabolic issues and reduced ATP synthesis, even at relatively low levels. The presence of this condition in somatic cell nuclear transfer (SCNT) embryos likely contributes to reduced prenatal and postnatal viability: the majority of the oocyte’s mitochondria is still present at the time of nuclear transfer, as well as through any further embryonic development post-fusion and activation. Though the somatic cell also contributes its mitochondria (which can successfully communicate with its nucleus), the oocyte’s mitochondria compose a greater proportion of the total …
Efficacy Of A Yfv-Specific Monoclonal Antibody In The Treatment Of Yf In A Hamster Model, Ryne Christiansen
Efficacy Of A Yfv-Specific Monoclonal Antibody In The Treatment Of Yf In A Hamster Model, Ryne Christiansen
Student Research Symposium
The yellow fever virus (YFV) is a flavivirus found mainly in South America and Africa. Infection may result in fever, chills, jaundice, nausea, and vomiting. Outbreaks may have up to 50% case mortality. Although Yellow Fever (YF) is a highly preventable disease through the use of an effective vaccine, there are no approved antivirals for this disease. An effective antiviral is necessary to treat infected individuals in areas where the YF vaccine was not used and an outbreak of YF occurs. In this study, female Syrian golden hamsters were infected with YFV and treated with YFV-specific monoclonal antibodies (mAbs). Weight …
Roles Of Nad In Dna Repair And Response To Oxidative Stress, Micah Forbush
Roles Of Nad In Dna Repair And Response To Oxidative Stress, Micah Forbush
Student Research Symposium
It has become a common trend for people to start their families at a later age, often due to lifestyle choices like achieving career goals first and waiting to achieve financial stability. Along with this trend of increasing parental age comes another, the decrease in fertility. While it is well established that female fertility declines significantly with age, current research is showing that male fertility may be impacted just as much. NAD (Nicotinamide Adenine Dinucleotide) is an important biochemical cofactor in most metabolic reactions, and importantly, is it also essential for DNA repair. As age increases in humans, the amount …
Impact Of Fecal Microbiota Transfer (Fmt) On Phenotype Of Mice Fed A Standard Diet And A Western-Style Diet Using A Colitis-Associated Colorectal Cancer Model, Abbey Horrocks
Student Research Symposium
A variety of genetic and environmental factors can affect the composition of the human gut microbiota, including a poor diet. Western diets are typically associated with dysbiosis and other adverse health outcomes that are expressed phenotypically. The primary objective of this study is to determine the contribution of gut microbiota from mice donors who have previously consumed one of two basal diets: 1) the standard AIN93G diet, which is designed to promote rodent health; and 2) the total Western diet (TWD), which promotes inflammation-associated colorectal tumorigenesis. The donors’ microbiota were transferred to a cohort of mice who were fed either …
Bolstering Southeast Asia's Livestock Biosecurity And Climate Change Resilience Essential For Global Health, Madelyn Kunzler
Bolstering Southeast Asia's Livestock Biosecurity And Climate Change Resilience Essential For Global Health, Madelyn Kunzler
Student Research Symposium
A large factor of climate change is its effect on infectious zoonotic diseases. Zoonotic diseases are diseases that can be transferred from animals into humans. Cases of zoonotic diseases have increased as humans have interacted more with animals, and as worldwide travel has become more frequent. It is predicted that 60% of emerging human diseases will be zoonotic. The cases will continue to increase to due climate change. As climate change continues, research has shown that new diseases will emerge from the melting permafrost and ice caps. It is also likely that pre-existing diseases will be able to migrate to …
Fecal Microbiota Transfer (Fmt) From Tumor-Bearing Mice Fed The Total Western Diet (Twd) Does Not Contribute To A Higher Tumor Burden In Mice Fed A Healthy Diet, Porter Green
Student Research Symposium
Colorectal cancer (CRC) is the third most common cause of cancer death in the United States. Diet and gut microbiome have shown to influence the development of colitis associated colorectal cancer (CAC). For this study, the goal was to determine the association between colon inflammation, diet and microbiome in the development of CAC in mice. The primary objective of this study was to determine the contribution of gut microbiota from mice donors who have previously consumed one of two basal diets: 1) the standard AIN93G diet, which is designed to promote rodent health; and 2) the total Western diet (TWD), …
Roles Of Nad+ In Testicular Aging And Epigenetic Sperm Modifications, Renata Hoskova
Roles Of Nad+ In Testicular Aging And Epigenetic Sperm Modifications, Renata Hoskova
Student Research Symposium
Since 1980, the average age of first-time fathers has been increasing. With increased age, sperm chromatin quality and nicotinamide adenine dinucleotide (NAD) levels are reduced. In order to condense around protamines, sperm DNA undergoes breaks, at which time epigenetic reprogramming occurs. In humans, about 2% of DNA stays wound to histones in spermatozoa. Histones carry post-translational modifications that control gene activity and have the potential to transmit epigenetic information to the offspring. Analysis of epigenetic sperm modifications is being conducted within niacin deficient versus niacin replete mice. The experimental plan includes the characterization of histone exchange in elongating spermatids via …
Rotc Cadets' Nutrition Knowledge & Behaviors: A Pilot Study, Mikaela Blake, Annika Israelsen, Tori Gossling, Jacob Lamb
Rotc Cadets' Nutrition Knowledge & Behaviors: A Pilot Study, Mikaela Blake, Annika Israelsen, Tori Gossling, Jacob Lamb
Student Research Symposium
The Reserve Officer Training Corps (ROTC) prepares college students for future military service. The ROTC includes a rigorous physical training program. As such, effective nutrition practices are necessary to maintain performance. The purpose of this study was to assess USU Cadets’ nutrition knowledge and practices to inform future research and intervention needs. Cadets were recruited through email and classroom announcements. Participants completed an online survey that gathered demographic, fitness, nutrition knowledge, nutrition behaviors, Intuitive Eating, perceived stress, and food security data. Results indicated that most cadets had a moderate knowledge of nutrition with a deficit in sports nutrition. This study …