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Exposure To Endocrine Disrupting Chemicals (Edcs) And Cardiometabolic Indices During Pregnancy: The Home Study, Ann M. Vuong, Joseph M. Braun, Andreas Sjödin, Antonia M. Calafat, Kimberly Yolton, Bruce P. Lanphear, Aimin Chen

Public Health Faculty Publications

Background: Toxicology studies have identified pregnancy as a window of susceptibility for endocrine disrupting chemicals (EDCs) and cardiometabolic indices in women. No study in humans, however, has examined EDC mixtures and cardiometabolic indices during pregnancy. Methods: We used the Health Outcomes and Measures of the Environment (HOME) Study to examine whether bisphenol A (BPA), polybrominated diphenyl ethers (PBDEs), per- and polyfluoroalkyl substances (PFAS), and phthalates are associated with blood pressure, glucose, and lipids in 388 pregnant women. We measured PBDEs and PFAS in serum at 16 weeks gestation, while BPA and phthalate metabolites were quantified in urine at 16 and …