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Efficacy And Safety Of Dotinurad In Hyperuricemic Patients With Or Without Gout: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Ayman Iqbal, Kinza Iqbal, Eisha Farid, Ali Ishaque, Muhammad Hasanain, Taha Bin Arif, Shajeea Arshad Ali, Sawai Singh Rathore, Mehreen Malik
Efficacy And Safety Of Dotinurad In Hyperuricemic Patients With Or Without Gout: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Ayman Iqbal, Kinza Iqbal, Eisha Farid, Ali Ishaque, Muhammad Hasanain, Taha Bin Arif, Shajeea Arshad Ali, Sawai Singh Rathore, Mehreen Malik
Department of Anaesthesia
Introduction: A systematic review and meta-analysis of the available randomized controlled trials (RCTs) were conducted to investigate the efficacy and safety of dotinurad in hyperuricemic patients with or without gout. Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that increases uric acid excretion by selectively inhibiting urate transporter 1 (URAT1). To the best of our knowledge, this is the first meta-analysis conducted to gauge the efficacy and safety of dotinurad.
Methods: Electronic databases (PubMed, the Cochrane Library, and ClinicalTrials.gov) were searched from inception till March 2, 2021, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis …