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Efficacy Of Souroubea-Platanus Dietary Supplement Containing Triterpenes In Beagle Dogs Using A Thunderstorm Noise-Induced Model Of Fear And Anxiety, Aleksandar Masic, Gary Landsberg, Bill Milgram, Zul Merali, Tony Durst, Pablo Sanchez Vindas, Mario Garcia, John Baker, Rui Liu, John Arnason
Efficacy Of Souroubea-Platanus Dietary Supplement Containing Triterpenes In Beagle Dogs Using A Thunderstorm Noise-Induced Model Of Fear And Anxiety, Aleksandar Masic, Gary Landsberg, Bill Milgram, Zul Merali, Tony Durst, Pablo Sanchez Vindas, Mario Garcia, John Baker, Rui Liu, John Arnason
Brain and Mind Institute
A novel botanical dietary supplement, formulated as a chewable tablet containing a defined mixture of Souroubea spp. vine and Platanus spp. Bark, was tested as a canine anxiolytic for thunderstorm noise-induced stress (noise aversion). The tablet contained five highly stable triterpenes and delivered 10 mg of the active ingredient betulinic acid (BA) for an intended 1 mg/kg dose in a 10 kg dog. BA in tablets was stable for 30 months in storage at 23 °C. Efficacy of the tablets in reducing anxiety in dogs was assessed in a blinded, placebo-controlled study by recording changes in blood cortisol levels and …