Medicine and Health Sciences Commons^™

Inhibiting Fatty Acid Binding Protein Family Members Decreases Multiple Myeloma Cell Proliferation Through Effecting The Myc Pathway, Mariah Farrell, Heather Fairfield, Anastasia D'Amico, Carolyne Falank, Connor Murphy, Michaela Reagan

Costas T. Lambrew Research Retreat 2021

FABP inhibition leads to increased survival of myeloma bearing mice and decreased cell growth by inhibiting MYC signaling.

Institutional Experience With Primary Interventional Radiology Sclerotherapy For Lymphatic Malformation, Obiyo Osuchukwu, Brenton Reading, Charlene Dekonenko, Wendy Jo Svetanoff, Jeff Thekkekara, Douglas C. Rivard, Charles L. Snyder, Tolulope A. Oyetunji

Costas T. Lambrew Research Retreat 2021

Interventional Radiology Sclerotherapy is effective for treatment of primary and recurrent lymphatic malformations

Plasma Concentrations Of Per- And Polyfluoroalkyl Substances And Body Composition From Mid-Childhood To Early Adolescence, Jaclyn Janis, Sheryl Rifas-Shiman, Shravanthi M. Seshasayee, Clifford J Rosen, Abby F Fleisch, Sharon Sagiv, Emily Oken

Costas T. Lambrew Research Retreat 2021

BACKGROUND

• Per- and polyfluoroalkyl substances (PFAS) may alter body composition by lowering anabolic hormones and increasing inflammation.

Prior studies have found positive, inverse, and null associations of PFAS concentrations with adiposity among children and adolescents.

Few studies have examined associations of PFAS concentrations with changes in body composition longitudinally.

No study has examined the association of PFAS plasma concentrations with lean mass.

Preventive Healthcare Services Receipt And Primary Care Provider Utilization Among People Who Inject Drugs, E K. Nenninger, Kinna Thakarar

Costas T. Lambrew Research Retreat 2021

Introduction:

People who inject drugs (PWID) face barriers to accessing primary care providers (PCPs) and preventive services, but are at increased risk for preventable infections

Preventive services can be accessed through PCPs, or while hospitalized or at community organizations like syringe service programs (SSPs)

The Introduction Of A Multimodal Clinical Pathway For Outpatient Total Knee Arthroplasty In The Era Of Covid-19, D Bunch, R Mountjoy, G Korsunsky, A Rana, C Sturgeon

Costas T. Lambrew Research Retreat 2021

The combination of a short acting spinal and muscle-sparing regional blocks, including adductor canal and iPACK blocks, can allow for successful outpatient total knee arthroplasty.

Ketamine Infusions For Post-Cesarean Pain In Patients With Opioid Use Disorder, Talitha Budi, Johanna Cobb, Wendy Craig, Heather Turcotte, Janelle Richard, Aurora Quaye

Costas T. Lambrew Research Retreat 2021

Discussion:

• Opioid consumption may be reduced during ketamine infusion without significant side effects

• Further investigation planned with a prospective, randomized, double-blind, placebo-controlled trial.

Improving The Care Of Patients With Cirrhosis At Mmc, Lesley B. Gordon, Elizabeth Herrle, Matt Buttarazzi, Monica Thim, Jenna S. Ptaschinski, Victoria Molina, Natalie Channell

Costas T. Lambrew Research Retreat 2021

Purpose: Improve the rate and timeliness of paracenteses for patients with decompensated cirrhosis.

Exploring Ob/Gyn Provider Knowledge, Practice And Confidence Levels Before And After Aces Training, Nadi Nina Kaonga, Alexandra Turnbull, Paula Vokey, Julia Brock

Costas T. Lambrew Research Retreat 2021

Trauma-informed training on ACEs improves provider confidence on screening and treating their prenatal patients.

Standardized Ekg Curriculum, Michael Ellerman, Jon Nichols, Sanjeev Francis

Costas T. Lambrew Research Retreat 2021

Goal: To study the effect of a standardized EKG curriculum on competency of interpreting common EKGs among internal medicine residents

Anterior-Based Muscle Sparing Approach For Total Hip Arthroplasty, Callahan M. Sturgeon, George M. Babikian, Brian J. Mcgrory, Adam J. Rana

Costas T. Lambrew Research Retreat 2021

A high value, high quality and low cost surgery: a 7.5 year single-center, retrospective case series

Impact Of Bowel Management Guidelines On Documentation And Patient Outcomes In The Intensive Care Unit, Alana Trottier, Paul Blakeslee, Kristiina Hyrkas

Costas T. Lambrew Research Retreat 2021

Introduction

• Bowel management (BM) is an inadvertently overlooked aspect of patient care for critically ill patients who have complex, immediate life-threatening health issues.

• Bowel dysfunction is common with the reported incidence of diarrhea between 3.3%-78% and constipation between 20-83%

• Studies suggest that BM guidelines can standardize care, improve documentation, and impact patient outcomes

• Use of BM guidelines has remained low, probably influenced by clinicians’ resistance to change, resulting in small to moderate improvements and difficulties sustaining new practices

• We anticipated that sustained changes require recognizing clinicians’ current practice, integrating modifications into existing workflow, and engaging …

Examining The Relationship Between Markers Of Emergency Department Crowding And Physician Wellbeing, Jessica Dibiase, Tania D. Strout, Samir Haydar, Karla Hyde, Elizabeth Hamilton, Christine Hein

Costas T. Lambrew Research Retreat 2021

Objectives-

Explore changes to EP wellbeing over time.

Evaluate the relationships between markers of ED crowding and boarding and EP wellbeing

Development Of Maine Ongoing Outreach Simulation Education (Moose), A Novel Telesimulation Program, To Improve Neonatal Resuscitation In A Rural Community Hospital, Allison Zanno, Misty Melendi, Micheline Chipman, Jeffrey Holmes, Alexa Craig, Samantha Piro, Anna Gilbert, Sarah Gabrielson, Leah Mallory, Anya Culter, Mary Ottolini

Costas T. Lambrew Research Retreat 2021

Objective- To implement monthly neonatal resuscitation telesimulation team training sessions in a rural community hospital delivery room that is feasible, sustainable, and replicable at other sites.

Leveraging Spiritual Care Resources To Reduce The Number Of Behavioral Events On An Acute And Intermediate Medical-Surgical Unit, Natasha Bartlett, Tia Jamir, Sally Langerak, Heather Weidemann

Costas T. Lambrew Research Retreat 2021

In 2018, R4/AVU an acute and intermediate care medical unit at Maine Medical Center (MMC), had a high level of distressing behavioral events (Code Grays) and staff stress.

Ideographic Modeling And Data Visualization Of Sleep, Affect, And Psychotic Symptoms: A Case Example, D M. Weiss, E Aslinger, W L. Cook, K A. Johnson, K M. Elacqua, R I. Mesholam-Gately, K A. Woodberry

Costas T. Lambrew Research Retreat 2021

Background:

1. Psychotic disorders are heterogeneous.

2. Current diagnostic categorizations are unable to capture individuals’ unique symptom experiences.

3. Newly-developed ideographic analyses and data visualization tools may be useful in assessing individuals’ symptom experiences and stimulating data informed care.

Investigation Of The Relationship Between Obesity, Weight Cycling, And Tumor Progression In Murine Myeloma Models, Heather Fairfield, Catherine R. Marinac, Mariah Farrell, Brenda M. Birmann, Michaela R. Reagan

Costas T. Lambrew Research Retreat 2021

We investigated this relationship in two murine myeloma models with a high fat diet (HFD) to induce obesity, and a diet cycling (DC) regimen to model weight cycling.

Perceptions Of Self-Efficacy And Experiences Of Mindfulness On Pain And Anxiety In Patients Undergoing A Colorectal Surgery: A Prospective Mixed Methods Study, Rebecca Brown, Julie Fitzgibbons, Rachel Farrington

Costas T. Lambrew Research Retreat 2021

Introduction

• Pain and anxiety have a physiological response on the body.

• Increased heart rate, respiratory rate and blood pressure can lead to complications, and thus longer hospitalization along with decreased patient satisfaction.

Parent Experience Of Hie And Hypothermia: A Call For Trauma Informed Care, Anna Sagaser, Betsy Pilon, Annie Goeller, Monica Lemmon, Alexa Craig

Costas T. Lambrew Research Retreat 2021

Objective:

To assess parents’ experience of communication with the medical team and involvement with their infant during HIE treatment.

Phq 9 Utilization In Maine Health, Steven Gerrish, Kerri Barton, Neil Korsen

Costas T. Lambrew Research Retreat 2021

The PHQ is a brief patient survey for diagnosing depression and monitoring response to treatment.

Multiple Myeloma Cells Graphs And Figures Inhibit Adipogenesis, Increase Senescencerelated And Inflammatory Gene Transcript Expression, And Alter Metabolism In Preadipocytes, Michaela R. Reagan, Heather Fairfield, Samantha Costa, Carolyne Falank, Mariah Farrell, Connor S. Murphy, Anastasia D'Amico, Heather Driscoll

Costas T. Lambrew Research Retreat 2021

Myeloma cells alter metabolism & induce senescence in adipocyte-lineage cells, suggesting that senescence-associated proteins are involved in multiple myeloma.

Process Evaluation Of A Smoking Cessation Group For Adults With Serious Mental Illness, David M. Weiss, Thomas Styron

Costas T. Lambrew Research Retreat 2021

Tobacco cessation strategies are needed to improve health outcomes among individuals with serious mental illness

The Maine Lung Cancer Coalition: A Statewide, Multi-Sector Partnership To Improve Evidence-Based Lung Cancer Prevention & Screening, Leo B Waterston, Liz Scharnetzki, Susan Leeds, Jaclyn A. Janis, Lee Lucas, Deborah Deatrick, Rebecca Boulos, Neil Korsen, Paul K.J. Han

Costas T. Lambrew Research Retreat 2021

MLCC has two primary goals:

1. Engage and educate about evidence based lung cancer prevention and screening practices

2. Develop, implement, and evaluate innovative programs to increase access to prevention, screening, and treatment services for all Mainers

The Nci/Nih Cancer Moonshot Biobank (Cmb) And The Maine Cancer Genetics/Genomics Education Core (Me-Cgec) Collaborate To Improve Cancer Care In Maine, Anne C. Breggia, Sue Miesfeldt, Neil Korsen, Jill Prescott, Lisa Lemire, Meghan Searight, Jamie Saunders, Scot Remick

Costas T. Lambrew Research Retreat 2021

Goal: To better understand drug resistance and sensitivity in patients with late stage (Stage III & IV) cancers that are receiving standard of care molecularly targeted therapies through next generation sequencing (NGS) of biopsy and blood samples collected longitudinally (diagnosis-- treatment--progression).

Thyroid Hormone-Clearing Deiodinase 3 Protects From Cranio- Encephalic And Cardiac Congenital Abnormalities, Arturo Hernandez, M Elena Martinez, Ilka Pinz, Marilena Preda, Thomas Gridley

Costas T. Lambrew Research Retreat 2021

Implications: Transient overexposure to TH during development may contribute to idiopathic congenital syndromes in humans (cleft palate, hydrocephalus, cardiac and Chiari malformations, others)

Would Surgeons Opt For Polypropylene Mesh If They Hypothetically Had Stress Urinary Incontinence Or Pelvic Organ Prolapse?, William J. Devan, Sanchita Bose, Dayron Rodriguez, Ricardo Munarriz, Linda Ng

Costas T. Lambrew Research Retreat 2021

Introduction

• Controversy surrounding vaginal mesh kits

• Many patients have negative connotations regarding mesh

• If patients were shown that their surgeons would opt for mesh –maybe this would help lessen the negativity?

Measuring Vastus Medialis Cross-Sectional Area With Panoramic Ultrasound Over Time, Kaitlin Minnehan, Elizabeth Scharnetzki, Kaitlyn Chin, Christina Holt, William Dexter

Costas T. Lambrew Research Retreat 2021

Panoramic ultrasound detected a statistically significant decrease in the VM CSA of participants after 70 days of bedrest without exercise.

Improving Safety Using Hfmea And Insitu Simulation Prior To Initiating Contrast Mri Studies In An Ambulatory Setting, Micheline Chipman, Todd Dadaleares, Heather Beaulieu, Leah Mallory

Costas T. Lambrew Research Retreat 2021

The objective of this event was to test a new system for emergency response to MRI contrast reactions by ensuring staff familiarity with emergency equipment and a newly drafted emergency response protocols, and to mitigate any LST identified.

Studying Emotions In Tele-Palliative Care, A Small Formative Study, Eric Anderson, Rebecca Hutchinson, Mollie Ruben, Noah Manning, Kathleen Walsh, Robert Gramling, Paul Han

Costas T. Lambrew Research Retreat 2021

Can emotional connection be formed in virtual consults?

A Simulation-Based Outreach Program Improves Delivery Room Team Confidence In Neonatal Resuscitation At Rural Community Hospitals, Allison Zanno, Misty Melendi, Micheline Chipman, Jeffrey Holmes, Alexa Craig, Samantha Piro, Anna Gilbert, Sarah Gabrielson, Leah Mallory, Anya Culter, Mary Ottolini

Costas T. Lambrew Research Retreat 2021

Objective- Our goal is to pilot the use of an onsite Neonatal Community Outreach Education Program to improve provider confidence with procedural skills and neonatal resuscitation in the delivery room.

The Mmc Biobank Is A Resource That Supports Biomedical Research, Anne C. Breggia, Sue Lapierre, Christopher Keister, Dawn Charnetzky, Hannah Brown, Joseph Nano, Sydney Robinson, Howard Feller, Susan Nester, Elizabeth Hamir, Heidi Ingersoll, Anthony Sellner, Trevor Jorgensen, Mike Jones

Costas T. Lambrew Research Retreat 2021

Mission: To provide normal and diseased annotated human biospecimens to the research community that supports discoveries leading to improved patient therapies and advances in personalized medicine.