Medicine and Health Sciences Commons^™

Nitrous Oxide Adaptation On Gene Expression In Breast Cancer Cells, Harsh Chheda, Estevan Ruiz Limón López, Zainab Mahmood, Ankit Sharma, Tina Tran, Uzma Abdulbaseer, Farouk Alshatti, James A. Radosevich

Chemistry and Physics Faculty Proceedings, Presentations, Speeches, Lectures

Hypothesis and Objective: Genes participating in the notch signaling pathway are influenced by exposure to high nitrous oxide (HNO) levels. Notch signaling pathway genes are responsible for regulating cell fate, differentiation, and apoptosis. Dysregulation of these genes can contribute to tumorigenesis. Alterations in the expression of these genes in MCF7 breast cancer cells could help determine the effects of the notch signaling pathway on tumorigenesis as a result of exposure to nitrous oxide.

Methods: Samples of cDNA from MCF7 and MCF7-HNO cells were used in DNA microarray analysis. Qualifying genes of interest provided a p value < .05. Differentially expressed genes (DEGs) were defined and categorized using the Gene Oncology Uniprot (GO) Molecular Function database. These cells were further analyzed using a proprietary bioinformatics analysis created by our laboratory.

Results: Exposure to HNO …

Effect Of Pandemic On Endoscopic Utilization In Colonic Volvulus: A Global Multicentric Study, Abhilash Perisetti Md, Hermant Goyal Md, Syed Mahanazuddin Phd, Saurabh Chandan Md, Ruthvik Allala Ba, Mariajose Rojas Md, Jonathan Kopel Phd, Sonali Sachdeva Mbbs, Mark M. Aloysius Md, Phd, Benjamin Tharian, Neil Sharma Md

Other Specialties

Introduction- Acute colonic volvulus (ACV) is a gastrointestinal emergency that results from the torsion of a segment of the colon either at the level of the sigmoid colon or cecum. It can lead to severe complications such as bowel infarction and peritonitis which can increase mortality. The COVID-19 pandemic has led to a significant reduction in endoscopic utilization globally. However, the data about endoscopy utilization in a gastrointestinal emergency such as ACV is not non-existent. Hence, we attempted to evaluate the rates of endoscopy utilization in 2020 compared to 2019 for ACV patients.

Methods- We used TriNetX, a federated cloud-based …

Safety Of Glucagon Use During Endoscopic Retrograde Cholangiopancreatography: A Retrospective Multicentric Study, Abhilash Perisetti Md, Hermant Goyal Md, Syed Mahanazuddin Phd, Rupinder Mann Md, Saurabh Chandan Md, Benjamin Tharian Md, Neil Sharma Md

Other Specialties

Introduction- Injectable glucagon inhibits gastrointestinal (GI) and duodenal motility by relaxing smooth muscles, decreasing the frequency and amplitude of phasic activity of the sphincter of Oddi. This enables endoscopists to enhance biliary cannulation and extract small bile duct stone. Additionally, glucagon can potentially worsen underlying hyperglycemia and hyperkalemia especially in patients with diabetes. It is unclear if glucagon impacts the adverse events of Endoscopic Retrograde Cholangiopancreatography (ERCP) such as rates of GI bleeding, GI perforation, post-ERCP pancreatitis (PEP) and in patient hospitalizations.

Methods We used TriNetX, a federated cloud-based network comprising of 92 healthcare organizations (HCOs) across the US. All …

Impact Of Pandemic On Epidemiology And Management Of Acute Colonic Pseudo Obstruction: Nationwide Clinical Data Research Network, Abhilash Perisetti Md, Hermant Goyal Md, Syed Mahanazuddin Phd, Mariajose Rojas Md, Mahesh Gajendran Md, Syed Ali Amir Sherazi Md, Shweta Gupta Md, Mbs, Ragesh Thandassery Md, Benjamin Tharian Md, Mrcp, Fracp, Neil Sharma Md

Other Specialties

Introduction Acute colonic pseudo-obstruction (ACPO), also known as Ogilvie’s syndrome, is characterized by massive acute dilatation of the large intestine without a mechanical cause. Early recognition to identify serious adverse events such as ischemia/ perforation is critical to reducing mortality rates. COVID-19 pandemic led to a significant shift of resources for the treatment of patients with reduced utilization of endoscopy and imaging, which could have impacted outcomes in patients with ACPO. In this study, we aim to identify the change in the clinical outcomes in ACPO patients in 2020.

Methods All adult patients with a new diagnosis of intestinal obstruction …

Reduced Incidence Of New Gastrointestinal Cancers Diagnosis During Covid-19 Pandemic, Abhilash Perisetti Md, Syed Mahanazuddin Phd, Rachana Yendala Md, Hermant Goyal Md, Benjamin Tharian Md, Mariajose Rojas Md, Neil Sharma Md

PCI Publications and Projects

Introduction- Gastrointestinal cancers such as esophageal, gastric, colon, liver, and pancreas cancers present a significant global challenge. The burden of these cancers depends mainly on early recognition and treatment initiation. COVID-19 pandemic led to a strain on multiple healthcare systems resulting in stay-at-home restraints, which might have impacted early recognition of these cancers. The data about the the incidence of GI cancers during the pandemic is scarce.

Methods- All adult patients with a new diagnosis of GI cancers in 2020 were compared with the patients in 2019. ICD-10 codes were utilized to identify these patient from TriNetX, a federated cloud-based …

Contingency Management Implementation: Strengthening Mat In Primary Care, Angela Colistra Lpc, Phd, Ms, Sophia Harbove Ms, Ctp, Yamelisa Taveras Ma, Caadc, Ccs, Abby S. Letcher Md, Nyann Biery Ms

Department of Family Medicine

No abstract provided.

The Focused Rapid Assessment Process (Frap): Utilizing Geospatial Mapping And Rapid Qualitative Analysis To Impact Cancer Survivorship Disparities, Autumn Kieber-Emmons Md, Mph

Department of Family Medicine

No abstract provided.

Measuring The Decrement Times Of Volatile Anesthetics In Drosophila Melanogaster Using Gas Chromatography-Mass Spectrometry, Jason Tolley

Scholar Week 2016 - present

Presentation Location: Warming House, Olivet Nazarene University

Abstract

Background

Model organisms are widely used in research, especially in the context of complex situations. One model organism that has been widely used is the common fruit fly, Drosophila melanogaster (D. mel). D. mel are most commonly used in the context of genetics, but they have also been widely used in research focusing on general anesthetics. One value that has not been measured in D. mel, however, as it relates to general anesthetics, is the decrement times. This is what was the present research set out to determine. …

S3: Post-Covid-19 Recovery Care Plan For Older Adults With Continuing Symptoms Of Breathlessness And Fatigue, Nancy M. Bryan, Marie Wright-Rolf Edd, Msn, Rn, Siboney Zelaya Ph.D., Mph, Msn Ed, Rn, Justin Carbonel

Annual Research Symposium

Background:

The CDC research actively continues gathering information related to short and long-term symptoms that remain following the acute phase of Covid-19 diagnosis (CDC, 2020).

Fatigue and shortness of breath are listed among the most commonly reported long-term symptoms of Covid-19:

1. Fatigue
2. Shortness of Breath
3. Cough
4. Joint Pain
5. Chest Pain (CDC, 2020).

Evidence suggests that older adults over the age of 60 who have multiple comorbidities are more susceptible and are at a higher risk of contracting the Covid-19 virus thus potentially prolonging recovery time post diagnosis (Greenhalgh, Knight, A’Court, Buxton, & Husain, 2020).

The Agency for Healthcare Research and …

A Case Of Abdominal Compartment Syndrome In Cardiac Surgery: A Rare, Potentially Fatal Complication., Michelle Chen, K. Gage Parr

Anesthesiology and Critical Care Medicine Faculty Posters and Presentations

No abstract provided.

Evidence-Based Practice: Delaying Infant Bathing, Gabrielle Wadle, Grace Frankland

Scholars Week

A hospital's policy regarding infant bathing is currently not congruent with best nursing practice. The hospital’s current policy is to bathe an infant once they are stable and their rectal temperature is at or above 98.6 °F. Although the infant may become stable within the first 24-hours of birth, the World Health Organization recommends that, “Bathing should be delayed until 24 hours after birth.” (2013, p. 4). Research has been completed to support delaying infant bathing until 24 hours post-delivery, suggesting potential modifications to current policy.

Pornography: Social, Emotional And Mental Implications Among Adolescents, William Kelly Canady

National Youth Advocacy and Resilience Conference

This presentation will explain the historical development of pornography. It will highlight four segments: 1- Porn’s impact on brain development of reward pathways, ultimately increasing the appetite for more porn. 2- Porn can be a false substitute for real intimacy, resulting in decreased sexual satisfaction with a real person and increased verbal and physical aggression. 3- Porn promotes sex trafficking, promotes multiple sex partners and reduced STD prevention. 4- A review of interventions available to assist clients in navigating a lifestyle away from pornography.

Approaching Difficult Topics With Patients Panel Discussion, Lynn M. Wilson Do, Jeremy Fischer, S Carter, Rob Danoff

Department of Family Medicine

No abstract provided.

Facilitating Student Community Health Immersion During Covid-19 Crisis: The Promise Neighborhood Health Equity Fellowship And Bridging The Gaps Community Health Internship Collaboration., Abby S. Letcher Md, Hasshan Batts, Sirry Alang, Mary Ellen Miller

Department of Family Medicine

No abstract provided.

In Patients With Mild To Moderate Alzheimer’S, Does Music Therapy Help To Decrease Mood Disturbances When Compared To Those Not Participating In Music Therapy?, Lauren Bauer

Capstone Showcase

Abstract:

Introduction: Affecting both memory and cognitive abilities, Alzheimer’s disease is a growing problem as the baby boomer population ages. Clinical trials for new medications fail or are slow going, researchers have sought alternatives to alleviate symptoms for patients of this disease. This paper will address the effect of music therapy on mood disturbance in patients with Alzheimer’s disease.

Method: A literature search was completed in November of 2019 using PubMed, EBSCO Search, ScienceDirect, and Google Scholar. Six articles were chosen based on relevance to the research question, study design, outcome, and results.

Results: Based on review, music …

The Efficacy Of Combination Of Psychosocial Interventions And Pharmacotherapeutic Intervention Compared To Standard Care In Patients Age 16-40 Diagnosed With Schizophrenia When Looking At Functional Capacity, Lisa Roth

Capstone Showcase

Introduction: Schizophrenia is a complex mental illness that arises from a combination of genetic factors, brain chemistry, substance use and environmental factors that affects the way a person behaves, thinks, and perceives. Schizophrenia has no cure, but it has several options for treatment including antipsychotic medications, psychotherapy, and education. Medication is frequently prescribed, and there is little evidence of how often psychotherapy is practiced to properly treat negative symptoms. The combination of these symptoms can have an impact on the functional capacity of an individual; this means that they may have less of an ability to proceed in a typical …

Efficacy Of Myo-Inositol In The Treatment Of Polycystic Ovarian Syndrome (Pcos), Rachel Mathews

Capstone Showcase

Polycystic ovarian syndrome (PCOS) is a disorder that results from insulin resistance. Symptoms include chronic anovulation, polycystic ovaries, acne, hirsutism, and infertility. Although there is currently no cure for PCOS, treatments such as metformin, clomiphene citrate, and reproductive assistive techniques (IVF) have been used to target specific symptoms. Recent research has suggested that myo-inositol may be beneficial in the treatment of PCOS. Therefore, this review analyzes the addition of myo-inositol (I) in adult patients with PCOS (P) compared to current methods such as metformin, clomiphene citrate, and assisted therapies alone (C) in improving ovulation and fertility (O). A literature search …

The Efficacy Of Platelet-Rich Plasma Administration For Rotator Cuff Tears, Angela Bekampis

Capstone Showcase

Despite advancing surgical techniques for rotator cuff tears (RCTs), the recovery from surgery is often painful and the rate of re-tear remains high. The use of platelet-rich plasma (PRP) is being studied as an adjunct therapy in order to increase the success of treatment. The goal of this study is to consolidate and compare the results of previous research to determine whether the use of PRP had significant benefit in the treatment of RCTs. Therefore the research question was: in adults (18+) diagnosed with a partial or full-thickness rotator cuff tears, does the use of PRP as an adjuvant treatment …

Opioid Use Disorder: The Timeline For Medication Assisted Therapy, Alexander Cristofori

Capstone Showcase

Opioid Use Disorder is patterns of opioid use leading to withdrawal, giving up important life events in order to use opioids, and excessive time spent using opioids, to name a few diagnostic criteria. The clinical progression of the disorder involves periods of acute exacerbation and remission that are cyclic in nature. Treatment is most effective when it includes both pharmacological and psychosocial modalities, referred to as medication assisted therapy (MAT). Three drugs used commonly in MAT-based treatment for OUD from oldest to newest include Methadone, Buprenorphine-naloxone, and Naltrexone. Treatment program models that prioritize total abstinence from the addictive substance attached …

The Efficacy Of In Vitro Fertilization In Treating Infertility Due To Anovulatory Pcos In Comparison To Ovulation Induction Via Letrozole, Amanda Salay

Capstone Showcase

Abstract:

Introduction: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder found in women of reproductive age that often causes infertility. The first-line treatment for infertility in anovulatory PCOS patients is ovulation induction. In vitro fertilization (IVF) is a third line treatment often used as a last resort. PCOS patients have higher failure risks of first- and second-line medications. Therefore, this review analyzes if adverse pregnancy outcomes (O) are reduced more with IVF (I) versus using letrozole for ovulation induction (C) in women aged 20-30 struggling with infertility due to anovulatory PCOS (P).

Methods: A literature search on Pubmed and EBSCOhost …