Medicine and Health Sciences Commons^™

Irritable Bowel Syndrome, Katherine Stillman

Nursing Student Class Projects (Formerly MSN)

Past understanding of the pathophysiology of irritable bowel syndrome (IBS) presents this chronic condition as a functional gastrointestinal disorder related to psychological causes. While no structural abnormalities are present in IBS, this poorly understood condition of persistent abdominal pain and altered bowel habits can be debilitating, contributing to a decreased quality of life. Current research has uncovered new evidence, that for many patients, symptoms may actually originate in the gut. An altered gut microbiome is now accepted as playing a central role in the development of the disorder. This poster summarizes the current pathophysiological concepts of IBS, including the role …

A Cross-Sectional Study Of Nausea In Functional Abdominal Pain: Relation To Mucosal Mast Cells And Psychological Functioning., Craig A. Friesen, Meenal Singh, Vivekanand Singh, Jennifer Verrill Schurman

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Nausea is a common symptom in youth with chronic abdominal pain. The aims of the current study were to assess: 1) the frequency of nausea in patients with functional dyspepsia (FD) and irritable bowel syndrome (IBS), respectively, as defined by Rome IV criteria; and, 2) relationships between nausea and mucosal inflammation as defined by antral and duodenal eosinophil and mast cell densities. A secondary aim was to assess relationships between nausea and other gastrointestinal symptoms, non-gastrointestinal somatic symptoms, and psychological dysfunction.

METHODS: Records from patients with pain associated functional gastrointestinal disorders were retrospectively reviewed for gastrointestinal and somatic symptoms …

Efficacy Of The Combination Of Pinaverium Bromide 100mg Plus Simethicone 300mg In Abdominal Pain And Bloating In Irritable Bowel Syndrome: A Randomized, Placebo-Controlled Trial, Max J. Schmulson, Jazmin Chiu-Ugalde, Adolfo Saez-Rios, Aurelio Lopez-Colombo, Gualberto J. Mateos-Perez, Jose Mario Remes-Troche, Sergio Sobrino-Cossio, Julio C. Soto-Perez, Jose L. Tamayo De La Cuesta, Oscar T. Teramoto-Matsubara, Juan Carlos Lopez Alvarenga

School of Medicine Publications and Presentations

Goals: We aimed to evaluate the efficacy and safety of PB+S (pinaverium bromide 100 mg plus simethicone 300 mg) in patients with irritable bowel syndrome (IBS).

Background: IBS is a multifactorial disorder; thus, combination therapy with different mechanisms of action is expected to be useful. PB+S has shown effectiveness in an open-label clinical study in IBS. However, there are no placebo-controlled trials.

Materials and Methods: IBS-Rome III patients with abdominal pain/discomfort for at least 2 days within the week prior to baseline assessment were included in this 12-week, randomized, doubleblind, placebo-controlled study of PB+S versus placebo, bid. The primary …

Are Probiotics Effective In Improving Quality Of Life In Adults With Irritable Bowel Syndrome?, Lauren O. Bruce

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective evidence-based medicine (EBM) review is to determine whether or not probiotics are effective in improving quality of life in adults with irritable bowel syndrome.

STUDY DESIGN: A systematic review of three double-blind randomized controlled trials (RCTs) written in the English language, published between the years 2016 and 2018.

DATA SOURCES: Three randomized controlled trials were published in peer-reviewed journals and found using PubMed and GoogleScholar databases.

OUTCOME(S) MEASURED: All three of the included studies measured the quality of life in adults with irritable bowel syndrome (IBS) utilizing the self-reported IBS-QOL questionnaire.

RESULTS: Each of …

Is Cognitive Behavioral Therapy Effective In Alleviating Ibs-Related Symptoms Experienced By Patients With Irritable Bowel Syndrome?, Nathan J. Ambrose

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not cognitive behavioral therapy is effective in alleviating IBS-related symptoms experienced by patients with irritable bowel syndrome.

STUDY DESIGN: A systematic review of three randomized controlled trials (RCTs) that were published in peer-reviewed journals in 2009, 2010, and 2018, all in the English language.

DATA SOURCES: All three studies discussed in this systematic review were found and accessed using PubMed.

OUTCOME MEASURED: Reduction of IBS symptoms as measured by the IBS-SSS questionnaire and the IBS symptom score analysis.

RESULTS: All three studies yielded a statistically significant reduction …

The Efficacy Of Peppermint Oil And Physical Activity Vs. Eluxadoline For The Treatment Of Irritable Bowel Syndrome, Julian Kang

Capstone Showcase

Introduction: Irritable bowel syndrome (IBS), defined as a chronic functional disorder that is characterized by recurring abdominal pain and altered bowel habits, is the most commonly diagnosed gastrointestinal disease in Western populations. While not yet completely understood, IBS has multiple factors believed to contribute to its pathophysiology. There are several treatment methods regarding non-pharmacological (such as lifestyle modifications) and pharmacological options (including anti-spasmodics, opioid agonists, and anti-depressants). Peppermint oil is a product derived from the natural herb, Mentha Piperita, and has been used as a nonpharmacological method to treat abdominal pain. Therefore, this review analyzes the use of …

An Intervention With Dance And Yoga For Girls With Functional Abdominal Pain Disorders (Just In Time): Protocol For A Randomized Controlled Trial, Anna Philipson, Stefan Särnblad, Lars Ekstav, Mats Eriksson, Ulrika L. Fagerberg, Margareta Möller, Evalotte Mörelius, Anna Duberg

Research outputs 2014 to 2021

©Anna Philipson, Stefan Särnblad, Lars Ekstav, Mats Eriksson, Ulrika L Fagerberg, Margareta Möller, Evalotte Mörelius, Anna Duberg. Background: Functional abdominal pain disorders (FAPDs) affect many children worldwide, predominantly girls, and cause considerable long-term negative consequences for individuals and society. Evidence-based and cost-effective treatments are therefore strongly needed. Physical activity has shown promising effects in the practical management of FAPDs. Dance and yoga are both popular activities that have been shown to provide significant psychological and pain-related benefits with minimal risk. The activities complement each other, in that dance involves dynamic, rhythmic physical activity, while yoga enhances relaxation and focus. Objective: …

Does Fibre-Fix Provided To People With Irritable Bowel Syndrome Who Are Consuming A Low Fodmap Diet Improve Their Gut Health, Gut Microbiome, Sleep And Mental Health? A Double-Blinded, Randomised Controlled Trial, Ran Yan, Mandy Murphy, Angela Genoni, Evania Marlow, Ian Dunican, Johnny Lo, Lesley Andrew, Amanda Devine, Claus T. Christophersen

Research outputs 2014 to 2021

Introduction:

A diet low in fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) is an effective way to reduce gut symptoms in people with irritable bowel syndrome (IBS). This diet reduces the intake of fermentable fibres, leading to changes of the gut microbiota and insufficient fermentation in the large bowel, resulting in reduced production of short-chain fatty acids (SCFAs), such as butyrate, which has unfavourable implications for gut health, sleep and mental health. This study will examine the effect of Fibre-fix, a supplement containing a mix of dietary fibres, on the human gut microbiome composition, fermentative capacity, sleep, quality of life …