Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Communication Sciences and Disorders (3)
- Life Sciences (3)
- Speech Pathology and Audiology (3)
- Speech and Hearing Science (3)
- Genetics and Genomics (2)
-
- Medical Specialties (2)
- Otolaryngology (2)
- Public Health (2)
- Disability Studies (1)
- Diseases (1)
- Genetics (1)
- Medical Genetics (1)
- Medical Sciences (1)
- Neuroscience and Neurobiology (1)
- Other Genetics and Genomics (1)
- Otorhinolaryngologic Diseases (1)
- Psychiatry and Psychology (1)
- Public Health Education and Promotion (1)
- Social and Behavioral Sciences (1)
- Institution
- Publication
- Publication Type
Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Direct Delivery Of Antisense Oligonucleotides To The Middle And Inner Ear Improves Hearing And Balance In Usher Mice, Jennifer J. Lentz, Bifeng Pan, Abhilash Ponnath, Christopher M. Tran, Carl Nist-Lund, Alice Galvin, Hannah Goldberg, Katelyn N. Robillard, Francine M. Jodelka, Hamilton E. Farris, Jun Huang, Tianwen Chen, Hong Zhu, Wu Zhou, Frank Rigo, Michelle L. Hastings, Gwenaëlle S.G. Géléoc
Direct Delivery Of Antisense Oligonucleotides To The Middle And Inner Ear Improves Hearing And Balance In Usher Mice, Jennifer J. Lentz, Bifeng Pan, Abhilash Ponnath, Christopher M. Tran, Carl Nist-Lund, Alice Galvin, Hannah Goldberg, Katelyn N. Robillard, Francine M. Jodelka, Hamilton E. Farris, Jun Huang, Tianwen Chen, Hong Zhu, Wu Zhou, Frank Rigo, Michelle L. Hastings, Gwenaëlle S.G. Géléoc
School of Medicine Faculty Publications
Usher syndrome is a syndromic form of hereditary hearing impairment that includes sensorineural hearing loss and delayed-onset retinitis pigmentosa (RP). Type 1 Usher syndrome (USH1) is characterized by congenital profound sensorineural hearing impairment and vestibular areflexia, with adolescent-onset RP. Systemic treatment with antisense oligonucleotides (ASOs) targeting the human USH1C c.216G>A splicing mutation in a knockin mouse model of USH1 restores hearing and balance. Herein, we explore the effect of delivering ASOs locally to the ear to treat hearing and vestibular dysfunction associated with Usher syndrome. Three localized delivery strategies were investigated in USH1C mice: inner ear injection, trans-tympanic membrane …
Primary Care Physician Perceptions Of Hearing Loss And Amplification: A Survey, Sophie Racine
Primary Care Physician Perceptions Of Hearing Loss And Amplification: A Survey, Sophie Racine
Dissertations, Theses, and Capstone Projects
The goal of this survey is to determine primary care physicians’ (PCP) views regarding hearing loss and hearing amplification. A questionnaire was created, using TypeForm©. Factors interrogated in the survey included structural aspects of the health care delivery system, presence of stigma among providers regarding hearing amplification, PCPs’ knowledge of hearing loss, the utility of amplification, official recommendations on screening and amplification, costs of hearing aids and risks of untreated hearing loss, and practitioners’ viewpoints and practice behaviors surrounding hearing loss and amplification. The survey instrument is comprised of four domains: 1) demographics, 2) knowledge of hearing loss and amplification, …
Induction Of Nocebo Effects By Verbal Suggestions During The Caloric Test, Abbey Weist
Induction Of Nocebo Effects By Verbal Suggestions During The Caloric Test, Abbey Weist
Dissertations, 2020-current
The caloric test is the most frequently performed vestibular diagnostic test and is considered the “gold-standard” for the assessment of the peripheral vestibular system. Using a warm or cool stimulus, the caloric test alters the temperature gradient in the vestibular system resulting in nausea and dizziness. The nocebo effect is a phenomenon that can occur when negative expectations result in negative effects. No study has examined whether expectations of nausea and dizziness during the caloric test enhance the experience of unwanted symptoms. The purpose of this investigation was to determine whether a nocebo response can be elicited during the caloric …
Advanced Phenotyping Of Otosclerosis In An Ontario Population And Two Large Newfoundland Families, Matthew B. Lucas
Advanced Phenotyping Of Otosclerosis In An Ontario Population And Two Large Newfoundland Families, Matthew B. Lucas
Electronic Thesis and Dissertation Repository
Otosclerosis is a relatively common hearing loss disorder characterized by abnormal bone growth in the otic capsule leading to stapes fixation. In approximately half of cases, otosclerosis is inherited as an autosomal dominant trait. Typically, gene discovery efforts rely on surgical confirmation, audiometry and occasionally acoustic reflexes to identify affected cases of otosclerosis within families, requiring that the otosclerosis was at an advanced stage to be detected. This makes it difficult to identify individuals with early otosclerosis. The use of advanced phenotyping to identify cases of otosclerosis was tested in an Ontario otosclerotic population as well as in two large …
Evidence For Gene-Smoking Interactions For Hearing Loss And Deafness In Japanese American Families, Jia Y Wan, Christina Cataby, Andrew Liem, Emily Jeffrey, Trina M Norden-Krichmar, Deborah Goodman, Stephanie A Santorico, Karen L Edwards
Evidence For Gene-Smoking Interactions For Hearing Loss And Deafness In Japanese American Families, Jia Y Wan, Christina Cataby, Andrew Liem, Emily Jeffrey, Trina M Norden-Krichmar, Deborah Goodman, Stephanie A Santorico, Karen L Edwards
Journal Articles
BACKGROUND: This study investigated the relationship between smoking and hearing loss and deafness (HLD) and whether the relationship is modified by genetic variation. Data for these analyses was from the subset of Japanese American families collected as part of the American Diabetes Association Genetics of Non-insulin Dependent Diabetes Mellitus study. Logistic regression with generalized estimating equations assessed the relationship between HLD and smoking. Nonparametric linkage analysis identified genetic regions harboring HLD susceptibility genes and ordered subset analysis was used to identify regions showing evidence for gene-smoking interactions. Genetic variants within these candidate regions were then each tested for interaction with …
Factors Affecting Seatbelt Use Among The Deaf And Hard-Of-Hearing, Deidre G. Mott
Factors Affecting Seatbelt Use Among The Deaf And Hard-Of-Hearing, Deidre G. Mott
Walden Dissertations and Doctoral Studies
In the United States, despite the proven significant economic, health, and social benefits of seatbelt use, millions of Americans do not use seatbelts. It is known that some factors, including obesity, reduce the rates of seatbelt use; however, a lack of research exists regarding whether individuals who are deaf or hard-of-hearing (HOH) have different rates of seatbelt use. The purpose of this study was to examine the difference in seatbelt use between deaf or HOH individuals and hearing individuals after adjusting for individual-level factors (BMI, marital status, education, and access to health care). The theoretical foundation for this study was …