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Full-Text Articles in Medicine and Health Sciences
Selinexor Hyperactivates Akt And Induces Its Nuclear Accumulation, Erin Lawrence
Selinexor Hyperactivates Akt And Induces Its Nuclear Accumulation, Erin Lawrence
Honors Scholars Collaborative Projects
Selinexor is currently being used in several clinical trials for cancer and has shown anti-cancer effects in combination with other chemotherapies. Clinical trials evaluating the use of selinexor in the treatment of triple negative breast cancer are limited, but in vitro studies show promising results in its ability to kill triple negative breast cancer cells. The mechanism by which this occurs, however, is not understood. The goal of this research was to determine the mechanism by which selinexor kills BT- 549 triple negative breast cancer cells.
Effect Of Amodiaquine On Gene Expression And Apoptosis In Colorectal Cancer Cells, Holly Pyles
Effect Of Amodiaquine On Gene Expression And Apoptosis In Colorectal Cancer Cells, Holly Pyles
Honors Scholars Collaborative Projects
This study used gene expression analysis to explore the specific response to amodiaquine in HCT116 colorectal cancer cells. Real-time PCR revealed that 20 human stress and toxicity genes were upregulated by at least 3 fold in HCT116 colorectal cancer cells treated with AMQ. Of these 20 upregulated genes, 9 were found to be pro-apoptotic and 2 were DNA damage repair genes, which supports our original hypothesis that amodiaquine is inducing a stress response in these cells. These results are consistent with previous research done by Qiao et al. (2013), as DNA damage repair genes were among the genes upregulated in …