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Full-Text Articles in Medicine and Health Sciences
Lung Cancer And Kidney Injury: An Updated Review, Bhargav Patel, Mohammad Ebrahimi Kalan, Maryam Khosravian, Audrey C. Tolouian, Ramin Tolouian, Mahnaz Aboufazeli, Masoumeh Asgharpour, Amirhesam Alirezaei
Lung Cancer And Kidney Injury: An Updated Review, Bhargav Patel, Mohammad Ebrahimi Kalan, Maryam Khosravian, Audrey C. Tolouian, Ramin Tolouian, Mahnaz Aboufazeli, Masoumeh Asgharpour, Amirhesam Alirezaei
Nursing Faculty Publications
Lung cancer is the leading cause of cancer deaths worldwide, accounting for an estimated 1.8 million deaths. Lung cancer is also the most common primary cancer leading to soft tissue (ST) metastasis. Renal disease may occur as a direct or indirect consequence of the cancer itself (e.g., postrenal obstruction, compression, or infiltration), its treatment (e.g., radiotherapy or chemotherapy), or its related complications (e.g., opportunistic infection). Existing evidence shows that the most frequent primary solid tumor responsible for renal metastasis is pulmonary carcinoma, followed by gastric, breast, soft tissue, and thyroid carcinomas. Chronic kidney disease is a potential risk factor in …
Identification Of A Novel Single Amino Acid Substitution (V666g) Of Jak1 From A Patient With Acute Lymphoblastic Leukemia Impairs Jak3 Mediated Il-2 Signaling, Alice Hernandez Grant
Identification Of A Novel Single Amino Acid Substitution (V666g) Of Jak1 From A Patient With Acute Lymphoblastic Leukemia Impairs Jak3 Mediated Il-2 Signaling, Alice Hernandez Grant
Open Access Theses & Dissertations
The Janus kinase (JAK) family, notably JAK1, JAK2 and JAK3 are recognized as oncogenic drivers in high risk Acute Lymphoblastic Leukemia (ALL). The bulk of activating JAK mutations are thought to occur within functional hot-spots across Janus Homology (JH) domains. The most frequently mutated regions is the JH2 pseudo-kinase, which provides a negative regulatory role to the adjacent catalytically active JH1 kinase domain. Despite the prevalence of JAK activating mutations and a need for new therapeutic inhibitors, there is a lack of understanding in the allosteric regulation of JAK kinases. Here we sought to identify mutations involved in driving ALL …