Medicine and Health Sciences Commons^™

The Status Of Antimicrobial Resistance In Campylobacterspp. Isolated From Animals And Humans In Southeast Asia: A Review, Saeid Jafari, Mahdi Ebrahimi, Taradon Luangtongkum

The Thai Journal of Veterinary Medicine

Campylobacteris considered to be a major foodborne pathogen associated with human bacterial gastroenteritis in many parts of the world. Southeast Asia (SEA) has been challenging for infectious diseases and antimicrobial resistance in recent years. Antibiotic resistance in Campylobacterisolates has been reported in humans and animals in this region.Since the SEA region is one of the top tourist destinations of the world, the provision of safe food is of importance for the travel-related foodborne infections. Therefore, it is essential to elucidate the status of antibiotic resistance of Campylobacterspp. in the SEA region to reduce the impact of infection and to implement …

Rabbit As A Reservoir Of Multidrug-Resistant Acinetobacter Baumanniiexpressing The Ade Multidrug Efflux Pumps, Sirawit Pagdepanichkit, Rungtip Chuanchuen

The Thai Journal of Veterinary Medicine

Acinetobacter baumanniihas emerged as a nosocomial pathogen and considered as a major cause of hospital acquired infections. While A. baumanniiin humans have been extensively studied in various situations, the study of A. baumanniiin companion animals is still limited. The aim of this study was to examine the presence and antimicrobial resistance profile of A. baumanniiisolates from companion rabbits. A total of 17 nasal swab from rabbit carcasses were obtained. A. baumanniiwas detected in 23.53% (4/17) of the samples and all the isolates exhibited resistance to chloramphenicol, erythromycin, spectinomycin and trimethoprim. Fifty percent of the isolates (2/4) were multidrug resistance (MDR) …

Dual Roles Of Neutrophils In Metastatic Colonization Are Governed By The Host Nk Cell Status., Peishan Li, Mingyang Lu, Jiayuan Shi, Li Hua, Zheng Gong, Qing Li, Leonard D. Shultz, Guangwen Ren

Faculty Research 2020

The role of neutrophils in solid tumor metastasis remains largely controversial. In preclinical models of solid tumors, both pro-metastatic and anti-metastatic effects of neutrophils have been reported. In this study, using mouse models of breast cancer, we demonstrate that the metastasis-modulating effects of neutrophils are dictated by the status of host natural killer (NK) cells. In NK cell-deficient mice, granulocyte colony-stimulating factor-expanded neutrophils show an inhibitory effect on the metastatic colonization of breast tumor cells in the lung. In contrast, in NK cell-competent mice, neutrophils facilitate metastatic colonization in the same tumor models. In an ex vivo neutrophil-NK cell-tumor cell …

Covid-19 Preclinical Models: Human Angiotensin-Converting Enzyme 2 Transgenic Mice., Cathleen Lutz, Leigh Maher, Charles Lee, Wonyoung Kang

Faculty Research 2020

Coronavirus disease 2019 (COVID-19) is a declared pandemic that is spreading all over the world at a dreadfully fast rate. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the pathogen of COVID-19, infects the human body using angiotensin-converting enzyme 2 (ACE2) as a receptor identical to the severe acute respiratory syndrome (SARS) pandemic that occurred in 2002-2003. SARS-CoV-2 has a higher binding affinity to human ACE2 than to that of other species. Animal models that mimic the human disease are highly essential to develop therapeutics and vaccines against COVID-19. Here, we review transgenic mice that express human ACE2 in the airway and …

Drowning Of Pet Owners During Attempted Animal Rescues: The Avir-A Syndrome, John Pearn, Amy E. Peden, Richard Charles Franklin

International Journal of Aquatic Research and Education

The rescuer who drowns can result from the attempted rescue of a human or an animal. We report here a total population analysis of all drowning fatalities for the 14-year period 1–July-2002 to 30-June-2016 which involved an attempted rescue of an animal. Cases were drawn from the Royal Life Saving National Fatal Drowning Database, which in turn, derived its data primarily from the National Coronial Information System (NCIS). Eight people drowned, all adults (ranging in age from 19-74 years), in the attempted rescue of an animal. Seven of the animals were domestic pet dogs, and in two cases farm animals. …

The Effect Of Hay Net Use On Cribbing Horses, Lauren Wesolowski

Undergraduate Honors Thesis Projects

Cribbing is a stereotypic behavior observed in horses, wherein the animal grasps a solid object with its front incisors and contracts its neck muscles to suck in air through its mouth, resulting in an audible grunt. Stereotypic behaviors such as cribbing are thought to be done in response to stress or insufficient stimulus in an animal’s living environment. Slow feeding hay nets can increase the amount of time horses spend eating daily hay rations. This research aims to use slow feeding hay nets to create a feeding process that is closer to natural grazing behavior and provide more stimulation for …

Evidence Of Increased Hypoxia Signaling In Fetal Liver From Maternal Nutrient Restriction In Mice., Bethany N Radford, Victor K M Han

Paediatrics Publications

BACKGROUND: Intrauterine growth restriction (IUGR) is a pregnancy condition where fetal growth is reduced, and offspring from IUGR pregnancies are at increased risk for type II diabetes as adults. The liver is susceptible to fetal undernutrition experienced by IUGR infants and animal models of growth restriction. This study aimed to examine hepatic expression changes in a maternal nutrient restriction (MNR) mouse model of IUGR to understand fetal adaptations that influence adult metabolism.

METHODS: Liver samples of male offspring from MNR (70% of ad libitum starting at E6.5) or control pregnancies were obtained at E18.5 and differential expression was assessed by …

Impaired Meningeal Lymphatic Vessel Development Worsens Stroke Outcome, Pavel Yanev, Katherine Poinsatte, Devon Hominick, Noor Khurana, Kielen R. Zuurbier, Marcus Berndt, Erik J. Plautz, Michael T. Dellinger, Ann M. Stowe

Neurology Faculty Publications

The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3) signaling for development. Here we characterize the effect of stroke on meningeal LVs, and the impact of meningeal lymphatic hypoplasia on post-stroke outcomes. We show that photothrombosis (PT), but not transient middle cerebral artery occlusion (tMCAo), induces meningeal lymphangiogenesis in young male C57Bl/J6 mice. We also show that Vegfr3^wt/mut mice develop significantly fewer meningeal LVs than Vegfr3^wt/wt mice. Again, meningeal lymphangiogenesis occurs in …

Functionalized Scaffold And Barrier Membrane With Anti-Bmp-2 Monoclonal Antibodies For Alveolar Ridge Preservation In A Canine Model, Seiko Min, Taewan Kim, Oksu Kim, Carames Goncalo, Tadahiko Utsunomiya, Takashi Matsumoto, Kayo Kuyama, Nikola Angelov

Journal Articles

INTRODUCTION: The aim of this study was to investigate the ability of anti-bone morphogenetic protein 2 monoclonal antibody (anti-BMP-2 mAb) to functionalize scaffolds to mediate bone regeneration in a canine model.

MATERIALS AND METHODS: The mandibular right premolar 4 (PM4) was extracted in eight beagle dogs and grafted with anti-BMP-2 mAb+anorganic bovine bone mineral with 10% collagen (ABBM-C) and porcine bilayer native collagen membrane (CM). The ABBM-C and CM were functionalized with either anti-BMP-2 mAb (test group) or an isotype matched control mAb (control group). Animals were euthanized at 12 weeks for radiographic, histologic, and histomorphometric analyses. Outcomes were compared …