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Bioscaffold Valve With And Without Mechanically Conditioned Stem Cells For The Treatment Of Critical Mitral Valve Diseases In The Young, Brittany A. Gonzalez

FIU Electronic Theses and Dissertations

Congenital heart disease, which includes heart valve defects, are the most common type of birth abnormality in the US. Infants with critical congenital valve disease have no established treatment-measure other than compassionate care options, owing to an absence of prosthetic valves in small sizes and their inability to support somatic growth. A regenerable valve would be appealing since these barriers could be overcome; it can potentially provide for growth, self-repair, infection resistance and be a permanent approach for replacing defective heart valves.

Porcine small intestinal submucosa (PSIS) bioscaffold was used to create valvular constructs with the possibility to grow overtime. …