Medicine and Health Sciences Commons^™

Circulating Tumour Dna: A Non-Invasive Biomarker For Melanoma, Ashleigh Cavell Mcevoy

Theses: Doctorates and Masters

Cutaneous melanoma accounts for 90% of all skin cancer deaths (Balch et al., 2010) and is responsible for 3.6% of deaths from cancer in Australia (Australian Institute of Health and Welfare, 2016). Whilst early detection and successful surgical removal of primary melanomas have improved survival rates (DeSantis et al., 2014), approximately 30% of these patients will have disease recurrence at some point in their lives (Soong et al., 1992; Soong et al., 1998). This is despite being considered disease free following treatment, which may have included surgical removal of the primary and/or its metastasis/es, radiation and/or systemic therapy. Whilst the …

The Effect Of Maximal Isometric Training On Doublet-Induced Force Enhancement And Its Relationship With Changes In Voluntary Rate Of Force Development, David Vernon Murray

Theses: Doctorates and Masters

Motor unit double discharges (i.e. doublets), which are excitatory potentials that occur at shorter-than-normal intervals (e.g. 5-10 ms) during normal muscle activation, are known to cause muscle force to exceed that predicted from a standard, linear summation of twitch forces. However, although a marked increase in the occurrence of motor unit doublets at the onset of a contraction has been observed after explosive-type exercise training, and has been correlated with changes in RFD (Van Cutsem et al., 1998), little is known about the influence of strength training on the physiological and biomechanical benefits derived from the phenomenon. The present research …

An Investigation Into The Creation Of Goal Scoring Opportunities In Women’S International Football; And A Comparison To Men’S International Football, Mark Scanlan

Theses: Doctorates and Masters

Football is the most popular sport in the world, played in over two hundred countries and it is governed by the Fédération Internationale de Football Association (FIFA), who host a World Cup every four year for both men and women. Women’s football is growing in terms of popularity, with this growth in popularity, research into the women’s game has begun to emerge. However, to date there is very little published research in women’s football that describes effective attacking strategies and the creation of goal scoring opportunities (GSO). Video of each match (52) from the Women’s World Cup (Canada 2015) was …

Genetic Determinants Of Rates Of Cognitive Decline In Preclinical Alzheimer’S Disease, Tenielle L. S. Porter

Theses: Doctorates and Masters

In 2015 the number of people worldwide living with Dementia was 46.8 million, with approximately 50-75% of these cases being clinically defined as Alzheimer’s disease (AD). Despite extensive efforts, clinical trials have so far failed to yield a treatment that successfully addresses the underlying cause of AD. This lack of treatment has been suggested, in part, to be a result of late stage of intervention in current clinical trial design. For this reason, greater focus has been placed on preclinical trials and in turn both the identification of individuals at-risk for AD and, amongst these, those that are expected to …

Does Facial Physiognomy In The Context Of Anoccupational Safety And Health Message Predict Outcomes?, Ian Parker

Theses: Doctorates and Masters

Physiognomy, the practice of looking to another person’s outward facial appearance to unmask the inner character of that person, has had a diverse historical impact within art, medicine, theology, anthropology, law, criminology, political history, psychology, psychiatry, and popular culture, since it was conceptualised in Greece during the 5th and 4th centuries B.C (Physiognomy, 1999-2009, 2009a). Aristotle, the prominent Greek philosopher, penned many chapters on physiognomic properties and touched upon strength/weakness, genius/stupidity, and other trait characteristics and their opposites in so far as such characteristics were associated with facial form (Physiognomy, 2006, 2009b).

In more modern times, facial recognition and evaluation …

Bone Fracture Incidence, Measurement And Adaptation: An Exploration Through The Continuum From Incidence To Measurement And Adaptation, Mark Jenkins

Theses: Doctorates and Masters

This research encompasses four studies exploring bone adaptation, fracture incidence, and preventative measures to decrease fracture risk and increase bone health. Study one was a clinical audit exploring incidence rates for appendicular fractures in children in Western Australia over ten years. Diagnostic and remedial approaches were explored in studies two, three and four by examining the between-day reliability of upper limb scans; reliability of the osteogenic index (OI) for upper-body strength and power exercises; and the diagnostic value or utility of using pQCT in disease profiling, respectively. Fracture rates in the limbs of children were found to be increasing each …

Gender Differences In Physical Performance Characteristics Of Competitive Surfers, Joanna Parsonage

Theses: Doctorates and Masters

Competitive surfing is judged on the performance and complexity of innovative and progressive manoeuvres. As such, surfers require the physical attributes of strength and power in both the upper and lower-body in order to facilitate performance. To date, there remains limited research pertaining to the physical performance characteristics of competitive female surfers, making it difficult to quantify the current gender gap in performance attributes. Therefore, the purpose of this thesis was fivefold: (1) to describe and compare the gender differences in physical performance characteristics of competitive surfers; (2) to investigate the reliability and validity of the isometric push-up (IPU), dynamic …

The Cryopreservation Of Human Semen, And Subsequent Evaluation Of A Commercially-Available Device To Isolate Motile Sperm, Callum Andrew Robinson

Theses: Doctorates and Masters

The cryopreservation of human semen is a vital asset in assisted reproductive technologies (ART). Although advances have been in the freezing of sperm, further refinement is both necessary and ongoing. Computer-assisted semen analysis (CASA) has been increasingly utilised in both research and diagnostic however there are a range of variables that must first be controlled in order to produce reliable measurements. Following thawing, sperm must be isolated from both the original seminal plasma and the cryoprotectants; the two most used isolation methods include density gradient centrifugation (DGC) and the swim-up method.

The present thesis sought to investigate the following areas …

Neuromuscular Factors Contributing To Reductions In Muscle Force After Repeated, High-Intensity Muscular Efforts, Benjamin J. C. Kirk

Theses: Doctorates and Masters

Fatigue can accumulate sufficiently to limit muscular force production during repeated, forceful muscle contractions, including those that occur in the occupational, clinical and athletic settings. Fatigue during such efforts is likely to result from disturbances to multiple processes in the nervous system and muscle. However, previous research examining the mechanisms underpinning fatigue have typically required subjects to perform low-level constant-force contractions or to repeat maximal efforts in a single set format. Such tasks do not translate well to occupational, daily living or athletic situations where high-intensity, yet submaximal, repeated efforts may be performed in work bouts (or sets) with brief …

A Framework For Development Of Android Mobile Electronic Prescription Transfer Applications In Compliance With Security Requirements Mandated By The Australian Healthcare Industry, Kyaw Kyaw Htat

Theses: Doctorates and Masters

This thesis investigates mobile electronic transfer of prescription (ETP) in compliance with the security requirements mandated by the Australian healthcare industry and proposes a framework for the development of an Android mobile electronic prescription transfer application. Furthermore, and based upon the findings and knowledge from constructing this framework, another framework is also derived for assessing Android mobile ETP applications for their security compliance.

The centralised exchange model-based ETP solution currently used in the Australian healthcare industry is an expensive solution for on-going use. With challenges such as an aging population and the rising burden of chronic disease, the cost of …

The Mechanics Of Front Leg Loading During Cricket Fast Bowling: Delivery Variations, Spell Demands, And The Effects Of Strength Training, Samuel J. Callaghan

Theses: Doctorates and Masters

The goal of fast bowling in cricket is to dismiss a batsman for as few runs as possible. To assist this goal, fast bowlers will attempt to maximise ball release velocity (BRV) to decrease the decision-making and stroke execution time of the opposing batsmen. Fast bowlers will also employ various delivery lengths (i.e. short, good and full) to assist in affecting a batsman’s stroke execution.

Several issues remain to be addressed with regards to the biomechanical assessment of fast bowling. This is particularly evident when analysing fast bowling performance (i.e. BRV), the implications of front foot loading (i.e. vertical and …

Breathing New Life: Investigating Ways To Improve The Mental Health Of People Living With Chronic Obstructive Pulmonary Disease In Western Australia, Tina Phan

Theses: Doctorates and Masters

Anxiety and depression are common comorbidities in people with chronic obstructive pulmonary disease (COPD), contributing to greater morbidity and mortality in an already vulnerable population. Despite the prevalence, few recommendations exist in global management guidelines for the detection and treatment of these comorbidities, reflecting the limited literature available on effective strategies for dealing with mental health issues in COPD populations. There is promising evidence that cognitive behavioural therapy (CBT) improves mental health outcomes in people with COPD. However, investigational studies have commonly reported participants’ lack of transport, lack of time and illness as barriers to recruitment and successful completion. This …

Ghanaian Parents’ Experiences Of Caring For Their Preterm Infants After Discharge From The Neonatal Unit - A Narrative Inquiry Study, Esther Abena Adama

Theses: Doctorates and Masters

The care of preterm infants is associated with stress. In the busy neonatal unit where highly skilled healthcare workers are always present, parents have reported being stressed when caring for their preterm infants in the neonatal unit. In Ghana, preterm birth is the highest cause of neonatal mortality with 70% of these morbidities and mortalities occurring in the community. Yet to date, no study in Ghana has explored how parents experience their care giving role after discharge from the neonatal unit into the community.

This study explored the experiences of caring for preterm infants in the neonatal unit and after …

Effects Of Long-Term Participation In Tennis On Cognitive Function In Elderly Individuals, Scott Culpin

Theses: Doctorates and Masters

Many studies have reported the relationship between exercise and cognition with conflicting results. This may be due to differences in intervention durations, session lengths, intensities, and type of exercise. It has been suggested that exercises requiring greater cognitive demand such as football, basketball and racquet sports, are protective against cognitive decline, compared to less cognitively demanding exercises such as swimming, cycling and running, however, research concerning exercise types are currently limited. The present study tested the hypothesis that elderly individuals who had been regularly playing tennis more than 10 years, would have greater cognitive function than those who had been …

The Influence Of A Simulated Olympic Distance Cycle Exercise On Subsequent Running Economy And Biomechanics In Triathletes, Chantelle Du Plessis

Theses: Doctorates and Masters

The multidisciplinary sport of triathlon provides a good model for testing whether a secondary task can be negatively affected by a preceding task, especially when movement patterns are different. Research suggests that cycling exercise impairs subsequent running performance by altering a runner’s economy and various mechanics (or technique-related) parameters. However, this is not an unambiguous finding. Furthermore, movement patterns are self-optimised during cycling and running to minimise the energy cost, yet the relationship between running mechanics and economy are not clear when different locomotor tasks are performed in succession

Two research studies were conducted with the focus of describing and …

Epidemiological Model Of The Transmission And Spread Of Hepatitis B Pandemic In Ghana, Kwaafo Akoto Awuah-Mensah

Theses: Doctorates and Masters

The world's attention to the burden and spread of hepatitis B has increased signicantly in the recent past. A number of interventions by way of treatment and immunisation have been initiated to fight the pandemic, especially in high prevalence regions such as Africa and Asia. Lack of good quality information about hepatitis B is a major hindrance to policy direction and comprehensive implementation of interventions in Sub-Saharan Africa designated as an endemic region. Limited studies on hepatitis B, coupled with lack of adequate health care systems and infrastructure, have led to ignorance or misconceptions and stigmatisation about the disease and …

The Utility Of Multidisciplinary Rehabilitation As A Treatment Strategy For Circadian Rhythm And Sleep Disturbances In Premanifest Huntington’S Disease, Danielle Megan Bartlett

Theses: Doctorates and Masters

Background: Huntington’s disease (HD) is a rare, neurodegenerative disease caused by an expanded cytosine-adenine-guanine (CAG) sequence in the Huntingtin gene, resulting in the production of an aberrant protein, mutant huntingtin (mHTT). The mHTT protein exhibits a toxic loss and gain in function, leading to degeneration of neurons in the brain. Consequently, the classic triad of motor, cognitive and mood features of the disease develop. Among the earliest features of HD are circadian rhythm and sleep disturbances. These anomalies present many years prior to formal clinical diagnosis of HD and, while it has been postulated that these disturbances arise as a …

Braking Ground Reaction Force During 90deg Sidestep Cut And Its Relationship To Leg Muscle Strength, Walter Yu

Theses: Doctorates and Masters

Previous studies on change of direction (COD) have reported that braking is an important factor for COD performance. However, previous studies have focused on the plant step and the penultimate step (PEN), thus little is known about deceleration before these steps. This study compared ground reaction forces (GRF) of two braking steps, the PEN and the step prior to PEN (PEN-1), the entry and exit velocity of the COD, and muscle function measures (leg press and leg curl one-repetition maximum, isometric and isokinetic strength, and drop jump performance) between faster and slower participants for a 90^o sidestep cut. This …

A Profile Of Game Style, Physical, Technical And Tactical Skills, And The Pathways That Underpin Expertise In Australian Youth Soccer Players, Bradley Scott Keller

Theses: Doctorates and Masters

The attainment of expertise has been the focus of research in many domains including music, chess and sport. This research has progressed with many theories detailing the best way to develop expertise and nurture talent in sport. Soccer is a multifaceted sport which requires a number of physical, technical and tactical skills to be successful, making it difficult to achieve expertise. Although Australia’s performance on the international stage is improving, there is a lack of evidence to inform the most effective development pathways to support the next wave of talented youth soccer players. Therefore, the aim of the thesis was …

N-Glycosylation Profiles As A Risk Stratification Biomarker For Type Ii Diabetes Mellitus And Its Associated Factors, Eric Adua

Theses: Doctorates and Masters

Worldwide, the prevalence of cardiometabolic diseases, particularly type II diabetes mellitus (T2DM), and to a lesser extent, metabolic syndrome (MetS), has increased dramatically. Despite this increase, there is still a lack of robust biomarkers for cardiometabolic diseases to secure better clinical outcomes. The enzymatic attachment of oligosaccharides (glycans) to proteins-glycosylation is of metabolic and physiological significance, as exploring aberrations of glycosylation profiles can reveal novel biomarkers. In parallel, this process could also explain the biological mechanisms that underpin a suboptimal health status (SHS), a reversible subclinical stage of a cardiometabolic disease. However, studies on the correlation between glycosylation and MetS/T2DM …

Design, Implementation And Evaluation Of The Impact Of A Body Image Professional Development Program For Early Childhood Educators, Karen Lombardi

Theses: Doctorates and Masters

Poor body image is a serious public health concern globally, and may lead to the development of poor mental and physical health, as well as eating disorders. Body image concerns were once believed to arise during puberty, though it is now reported children as young as three years of age present with such problems. Early intervention is therefore an important strategy to improve mental and physical health outcomes for very young children, and educators are an obvious conduit to build confidence, self-esteem and resilience of such children. In order for them to adequately fulfil this role, educators must first understand …

Impact Of Biobanks On Research Outcomes In Rare Diseases：A Systematic Review, Monique Garcia

Theses: Doctorates and Masters

Rare diseases (RDs) are a global priority yet are still under researched. When combined, RDs are common, with individual diseases numbering approximately 5,000-8,000, equating to approximately 7% of the population in Europe. Extrapolating this figure for Australia suggests that about 1.2 million people are affected by RDs, with about 400,000 of those being children. The WA Rare Diseases Strategic Framework 2015-2018, the first strategy for rare diseases in Australia, recognises that in order to alleviate the significant burden of rare diseases, innovative translational tools that facilitate research into new diagnostic and therapeutic strategies should be given priority.

Registries facilitate clinical, …

Assessment Of Joint Kinetics In Elite Sprint Cyclists, Lynne Munro

Theses: Doctorates and Masters

Sprint cycling requires the production of explosive muscle power outputs up to very high pedalling rates. The ability to assess muscular function through the course of the sprint would aid training practices for high-level performers. Inverse dynamics provides a non-invasive means of estimating the net muscle actions acting across any joint contributing to movement. However, analysis of joint kinetics requires motion-capture techniques that present some unique challenges for cycling. This thesis presents three studies investigating the application of a custom-designed force pedal system to examine the joint kinetics of elite trained track sprint cyclists. To provide the basis for selecting …

Ultrasound Measurements On The Inferior Vena Cava By Renal Nursing Staff For Assessment And Management Of Intravascular Volume Status In Haemodialysis Patients, Ulrich Steinwandel

Theses: Doctorates and Masters

Title: Ultrasound measurements on the inferior vena cava (IVC-US) by renal nursing staff for assessment and management of intravascular volume status in haemodialysis patients.

Aims: The primary aim of this thesis was to provide evidence that renal nurses could safely and efficiently perform IVC-US on haemodialysis patients to obtain objective assessment of intravascular volume status and potentially reduce adverse events and morbidity. The secondary aims for this study were: (1) conduct a systematic literature review to identify evidence if renal nurses have previously used this method for intravascular volume assessment; (2) teach a renal nurse through a staged educational programme, …

Antibiotic Resistance In Gram Negative Bacteria Isolated From Fish Sold In Western Australia, Hannah Kathleen Robinson

Theses: Doctorates and Masters

Background Information The global misuse and overuse of antibiotics in human medicine and the animal production industry is contributing to the development of antibiotic resistance in bacteria. This is a serious threat to modern medicine and public health. Antibiotic resistant organisms can cause severe infections in humans which are difficult to treat, and in some cases impossible to resolve which can lead to premature death. Several studies have been conducted across the globe to assess the use of antibiotics in the seafood industry and the associated health risks, however, limited studies have recently explored this risk in an Australian setting. …

High-Intensity Interval Eccentric Cycling: Acute And Chronic Effects, Marcin Lipski

Theses: Doctorates and Masters

Eccentric cycling training has been prescribed in continuous and low intensities protocols, based on concentric cycling parameters. While the lower metabolic demand of eccentric than concentric cycling is advantageous for clinical or ‘at-risk’ populations, it is a disadvantage for cardiovascular and pulmonary adaptations. High-intensity interval protocols may increase both, strength and endurance. Thus, this research project compared i) an incremental concentric and eccentric cycling test until exhaustion for the relationship between power output and physiological parameters <Study1>; ii) interval and continuous eccentric cycling protocols for oxygen consumption, perceived exertion and enjoyment <Study 2>; and iii) aerobic performance, muscle …

The Delivery Of Primary Health Care In Remote Australian Communities: A Grounded Theory Study Of The Perspective Of Nurses, Kylie Mccullough

Theses: Doctorates and Masters

Around 85% of Australia’s landmass is remote and sparsely populated. Across these vast areas of desert, wilderness and tropical islands, nurses provide the majority of health care services. The residents of Australia’s remote communities have poorer health status than their metropolitan counterparts. The proportion of Indigenous people is high and health and social disadvantage is widespread. The characteristics of each remote community are unique and often reflect challenges associated with distance to tertiary health services and limited health resources. As a result, nursing practice within this context is very different to other nursing contexts. Despite recognition of Primary Health Care …

Public Health Implications Of Metal Ash Concentrations From Prescribed Burns: A Study Of Open Jarrah Forests, John Edwards

Theses: Doctorates and Masters

Ash is not a homogenous product. It is the solid residue of combustion and contains a complex mixture of chemical products. The fire that produces ash is non-discriminatory in that it will burn anything that is combustible. The ash residue resulting from fires varies and is dependent on its source, and burn characteristics such as the temperature of the fire. Ash comprises particles of carbon, soot and trace elements. Ash presents public health risk to people and communities, through direct and indirect ingestion, inhalation and absorption. The health effects of ash exposure are not limited to symptoms affecting the eyes, …

Holistic Health: Shaping Women’S Experiences Of Positive Body Image, Helen Elizabeth Monks

Theses: Doctorates and Masters

This PhD thesis seeks to contribute to a nuanced understanding of positive body image and how it is expressed among a group of women participating in holistic health culture in a modern Western society. Qualitative data were collected from in-depth ethnographic interviews with 25 women in Perth, Western Australia, to illuminate an understanding of their holistic health beliefs and practices, perceptions of appearance and health ideals, as well as their understandings of positive body image. Thematic analysis of the data through Nvivo revealed several overarching themes, demonstrating how certain aspects of holistic health culture may encourage or dissuade the development …

Exploring The Preparedness Of Novice (Student) Paramedics For The Mental Health Challenges Of The Paramedic Profession: Using The Wisdom Of The Elders, Lisa Holmes

Theses: Doctorates and Masters

This study investigates the preparedness of novice (student) paramedics for the mental health challenges of the paramedic profession and identifies the coping strategies used by veteran paramedics to successfully meet these challenges. The lived experience of veteran paramedics is utilised to provide this important assistance.

Initially, two surveys were developed and administered to 16 course coordinators and 302 students of the 16 accredited undergraduate degree paramedicine courses across Australia and New Zealand, to identify the perceived need (for preparation) within the curriculum. In addition, the anticipations, confidence and fears of novice (student) paramedics, course coordinators and veteran paramedics were also …