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Full-Text Articles in Medicine and Health Sciences

The Current State Of Subjective Training Load Monitoring—A Practical Perspective And Call To Action, Joseph O. C. Coyne, G. Gregory Haff, Aaron J Coutts, Robert U. Newton, Sophia Nimphius Dec 2018

The Current State Of Subjective Training Load Monitoring—A Practical Perspective And Call To Action, Joseph O. C. Coyne, G. Gregory Haff, Aaron J Coutts, Robert U. Newton, Sophia Nimphius

Research outputs 2014 to 2021

This commentary delivers a practical perspective on the current state of subjective training load (TL) monitoring, and in particular sessional ratings of perceived exertion, for performance enhancement and injury prevention. Subjective measures may be able to reflect mental fatigue, effort, stress, and motivation. These factors appear to be important moderators of the relationship TL has with performance and injury, and they also seem to differ between open and closed skill sports. As such, mental factors may affect the interaction between TL, performance, and injury in different sports. Further, modeling these interactions may be limited due to the assumption that an …


The Effect Of Altering Body Posture And Barbell Position On The Between-Session Reliability Of Force-Time Curve Characteristics In The Isometric Mid-Thigh Pull, Stuart N. Guppy, Claire J. Brady, Yosuke Kotani, Michael H. Stone, Nikola Medic, Guy Gregory Haff Nov 2018

The Effect Of Altering Body Posture And Barbell Position On The Between-Session Reliability Of Force-Time Curve Characteristics In The Isometric Mid-Thigh Pull, Stuart N. Guppy, Claire J. Brady, Yosuke Kotani, Michael H. Stone, Nikola Medic, Guy Gregory Haff

Research outputs 2014 to 2021

Seventeen strength and power athletes (n = 11 males, 6 females; height: 177.5 ± 7.0 cm, 165.8 ± 11.4 cm; body mass: 90.0 ± 14.1 kg, 66.4 ± 13.9 kg; age: 30.6 ± 10.4 years, 30.8 ± 8.7 years), who regularly performed weightlifting movements during their resistance training programs, were recruited to examine the effect of altering body posture and barbell position on the between-session reliability of force-time characteristics generated in the isometric mid-thigh pull (IMTP). After participants were familiarised with the testing protocol, they undertook two testing sessions which were separated by seven days. In each session, the participants …


Impact Of Biobanks On Research Outcomes In Rare Diseases: A Systematic Review, Monique Garcia, Jenny Downs, Alyce Russell, Wei Wang Nov 2018

Impact Of Biobanks On Research Outcomes In Rare Diseases: A Systematic Review, Monique Garcia, Jenny Downs, Alyce Russell, Wei Wang

Research outputs 2014 to 2021

BACKGROUND: Alleviating the burden of rare diseases requires research into new diagnostic and therapeutic strategies. We undertook a systematic review to identify and compare the impact of stand-alone registries, registries with biobanks, and rare disease biobanks on research outcomes in rare diseases.

METHODS: A systematic review and meta-aggregation was conducted using the preferred reporting items for systematic reviews and meta-analyses (the PRISMA statement). English language publications were sourced from PubMed, Medline, Scopus, and Web of Science. Original research papers that reported clinical, epidemiological, basic or translational research findings derived from data contained in stand-alone registries, registries with biobanks, …


The Association Between Subclass-Specific Igg Fc N-Glycosylation Profiles And Hypertension In The Uygur, Kazak, Kirgiz, And Tajik Populations, J. N. Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, J. Zhang, Hao Wang, D. Q. Zheng, X. Y. Zhang, H. L. Peng, Z. Y. Zhao, D. Liu, Yang Sun, Q. Sun, Q. H. Li, J. X. Zhang, Ming Sun, W. J. Cao, Ana Momčilović, Genadij Razdorov, L. J. Wu, Alyce Russell, Y. X. Wang, Song Manshu, Gordan Lauc, Wei Wang Sep 2018

The Association Between Subclass-Specific Igg Fc N-Glycosylation Profiles And Hypertension In The Uygur, Kazak, Kirgiz, And Tajik Populations, J. N. Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, J. Zhang, Hao Wang, D. Q. Zheng, X. Y. Zhang, H. L. Peng, Z. Y. Zhao, D. Liu, Yang Sun, Q. Sun, Q. H. Li, J. X. Zhang, Ming Sun, W. J. Cao, Ana Momčilović, Genadij Razdorov, L. J. Wu, Alyce Russell, Y. X. Wang, Song Manshu, Gordan Lauc, Wei Wang

Research outputs 2014 to 2021

Hypertension results from the interaction of genetic and acquired factors. IgG occurs in the form of different subclasses, of which the effector functions show significant variation. The detailed differences between the glycosylation profiles of the individual IgG subclasses may be lost in a profiling method for total IgG N-glycosylation. In this study, subclass-specific IgG Fc glycosylation profile was investigated in the four northwestern Chinese minority populations, namely, Uygur (UIG), Kazak (KZK), Kirgiz (KGZ), and Tajik (TJK), composed of 274 hypertensive patients and 356 healthy controls. The results showed that ten directly measured IgG N-glycan traits (i.e., IgG1G0F, IgG2G0F, IgG2G1FN, IgG2G1FS, …


Keep Calm And Carry On: Parental Opinions On Improving Clinical Dietary Trials For Young Children, Analise Nicholl, Therese O'Sullivan Aug 2018

Keep Calm And Carry On: Parental Opinions On Improving Clinical Dietary Trials For Young Children, Analise Nicholl, Therese O'Sullivan

Research outputs 2014 to 2021

Recruitment can be an issue for paediatric research. We aimed to investigate parental opinions of paediatric clinical assessments, and to combine findings with recent literature to inform the design of a clinical dietary trial. We used convenience sampling to recruit 17 parents of children aged 2⁻6 years from two community playgroups in Perth, Western Australia. Three focus groups considered proposed child assessments, study design, and potential study enrolment. Qualitative thematic analysis of focus group transcripts used NVivo 11 (QSR, Melbourne, VIC, Australia). Four main parental concerns emerged, presented here with solutions combining parent responses and relevant literature. (1) Parent and …


Future Warming And Acidification Result In Multiple Ecological Impacts To A Temperate Coralline Alga, Megan J. Huggett, Kathryn Mcmahon, Rachele Bernasconi Aug 2018

Future Warming And Acidification Result In Multiple Ecological Impacts To A Temperate Coralline Alga, Megan J. Huggett, Kathryn Mcmahon, Rachele Bernasconi

Research outputs 2014 to 2021

Coralline algae are a crucial component of reef systems, stabilising reef substrate, providing habitat and contributing to accretion. Coralline algae and their surface microbial biofilms are also important as settlement cues for marine invertebrates, yet few studies address the impact of future environmental conditions on interactions between coralline algae, reef microbes and settlement by larvae of marine invertebrates. We exposed the temperate coralline algal species Amphiroa gracilis to warming and/or acidification scenarios for 21 days. Algae became bleached but photosystem II function was not measurably impacted. Settlement by larvae of the sea urchin Heliocidaris erythrogramma was reduced and the structure …


The Assessment Of Isometric, Dynamic, And Sports-Specific Upper-Body Strength In Male And Female Competitive Surfers, Joanna Parsonage, Josh Secomb, Rebecca Dowse, Brendon Ferrier, Jeremy Sheppard, Sophia Nimphius Jun 2018

The Assessment Of Isometric, Dynamic, And Sports-Specific Upper-Body Strength In Male And Female Competitive Surfers, Joanna Parsonage, Josh Secomb, Rebecca Dowse, Brendon Ferrier, Jeremy Sheppard, Sophia Nimphius

Research outputs 2014 to 2021

The primary purpose of this study was to investigate gender differences in the dynamic strength index (DSI): an assessment of upper-body dynamic strength relative to maximal isometric strength. The secondary purpose was to investigate gender differences in the dynamic skill deficit (DSD): an assessment of sports-specific dynamic strength relative to maximal isometric strength, and its association with a sports-specific performance measure in surfers. Nine male (age = 30.3 ± 7.3 yrs) and eight female (age = 25.5 ± 5.2 yrs) surfers undertook three upper-body assessments: isometric push-up, dynamic push-up, and a force plate pop-up to determine the DSI and DSD. …


The Changes Of Immunoglobulin G N-Glycosylation In Blood Lipids And Dyslipidaemia, Di Liu, Xi Chu, Hao Wang, Jing Dong, Si-Qi Ge, Zhong-Yao Zhao, Hong-Li Peng, Ming Sun, Li-Juan Wu, Man-Shu Song, Xiu-Hua Guo, Qun Meng, You-Xin Wang, Gordan Lauc, Wei Wang Jan 2018

The Changes Of Immunoglobulin G N-Glycosylation In Blood Lipids And Dyslipidaemia, Di Liu, Xi Chu, Hao Wang, Jing Dong, Si-Qi Ge, Zhong-Yao Zhao, Hong-Li Peng, Ming Sun, Li-Juan Wu, Man-Shu Song, Xiu-Hua Guo, Qun Meng, You-Xin Wang, Gordan Lauc, Wei Wang

Research outputs 2014 to 2021

Background

Alternative N-glycosylation has significant structural and functional consequences on immunoglobulin G (IgG) and can affect immune responses, acting as a switch between pro- and anti-inflammatory IgG functionality. Studies have demonstrated that IgG N-glycosylation is associated with ageing, body mass index, type 2 diabetes and hypertension.

Methods

Herein, we have demonstrated patterns of IgG glycosylation that are associated with blood lipids in a cross-sectional study including 598 Han Chinese aged 20–68 years. The IgG glycome composition was analysed by ultra-performance liquid chromatography.

Results

Blood lipids were positively correlated with glycan peak GP6, whereas they were negatively correlated with …


Evaluation Of Individual And Combined Markers Of Urine Dipstick Parameters And Total Lymphocyte Count As A Substitute For Cd4 Count In Low-Resource Communities In Ghana, Enoch Odame Anto, Christian Obirikorang, Emmanuel Acheampong, Bright Amankwaa, Bright Oppong Afranie, Sampson Donkor, Isaac Hope, Juliana Jommo, Esther Osaah Jan 2018

Evaluation Of Individual And Combined Markers Of Urine Dipstick Parameters And Total Lymphocyte Count As A Substitute For Cd4 Count In Low-Resource Communities In Ghana, Enoch Odame Anto, Christian Obirikorang, Emmanuel Acheampong, Bright Amankwaa, Bright Oppong Afranie, Sampson Donkor, Isaac Hope, Juliana Jommo, Esther Osaah

Research outputs 2014 to 2021

We evaluated the individual and combined levels of urine dipstick and total lymphocyte count (TLC) as surrogate markers for CD4 count in a low-resource community in Ghana. This cross-sectional study recruited 200 HIV-infected patients from the Saint Francis Xavier Hospital, Assin Fosu, Ghana. Complete blood count, CD4 count, and urine dipstick analysis were measured for participants. The threshold values were determined as/


A Diagnostic Autoantibody Signature For Primary Cutaneous Melanoma, Pauline Zaenker, Johnny Lo, Robert L. Pearce, Phillip Cantwell, Lester Cowell, Mark Lee, Christopher Quirk, Henry Law, Elin S. Gray, Mel R. Ziman Dr Jan 2018

A Diagnostic Autoantibody Signature For Primary Cutaneous Melanoma, Pauline Zaenker, Johnny Lo, Robert L. Pearce, Phillip Cantwell, Lester Cowell, Mark Lee, Christopher Quirk, Henry Law, Elin S. Gray, Mel R. Ziman Dr

Research outputs 2014 to 2021

Melanoma is an aggressive form of skin cancer that is curable by surgical excision in the majority of cases, if detected at an early stage. To improve early stage melanoma detection, the development of a highly sensitive diagnostic test is of utmost importance. Here we aimed to identify antibodies to a panel of tumour associated antigens that can differentiate primary melanoma patients and healthy individuals. A total of 245 sera from primary melanoma patients and healthy volunteers were screened against a high-throughput microarray platform containing 1627 functional proteins. Following rigorous statistical analysis, we identified a combination of 10 autoantibody biomarkers …


Scoring Analysis Of The Men’S 2014, 2015 And 2016 World Championship Tour Of Surfing: The Importance Of Aerial Manoeuvres In Competitive Surfing, Brendon Ferrier, Jeremy Sheppard, Oliver R.L. Farley, Josh L. Secomb, Joanna Parsonage, Robert Newton, Sophia Nimphius Jan 2018

Scoring Analysis Of The Men’S 2014, 2015 And 2016 World Championship Tour Of Surfing: The Importance Of Aerial Manoeuvres In Competitive Surfing, Brendon Ferrier, Jeremy Sheppard, Oliver R.L. Farley, Josh L. Secomb, Joanna Parsonage, Robert Newton, Sophia Nimphius

Research outputs 2014 to 2021

The aim of this study was to investigate the impact of aerial manoeuvres on scoring in professional surfing. 23,631 waves were analysed for the number and types of aerial manoeuvres performed from the 2014, 2015 and 2016 Men’s World Championship Tour. Additionally, the awarded score, timing and order of the aerial was also analysed. Descriptive statistics and Two Way ANOVA’s were performed with Sidak Multiple Comparisons Post Hoc analysis. Results were a significantly higher score being awarded (P ≤ 0.0001) when including an aerial in competition across all three seasons. In 2015 surfers were awarded a significantly larger score …


Colorectal Cancer Survival Rates In Ghana: A Retrospective Hospital-Based Study, Francis Agyemang-Yeboah, Joseph Yorke, Christian Obirikorang, Emmanuella Nsenbah Batu, Emmanuel Acheampong, Emmanuel Amankwaa Frimpong, Enoch Odame Anto, Bright Amankwaa Jan 2018

Colorectal Cancer Survival Rates In Ghana: A Retrospective Hospital-Based Study, Francis Agyemang-Yeboah, Joseph Yorke, Christian Obirikorang, Emmanuella Nsenbah Batu, Emmanuel Acheampong, Emmanuel Amankwaa Frimpong, Enoch Odame Anto, Bright Amankwaa

Research outputs 2014 to 2021

BACKGROUND: Colorectal cancer (CRC) is one of the commonest cancers associated with diverse prognosis times in different parts of the world. Despite medical interventions, the overall clinical outcomes and survival remains very poor for most patients in developing countries. This study therefore investigated the survival rate of colorectal cancer and its prognostic factors among patients at Komfo Anokye Teaching Hospital, Ghana.

METHODOLOGY: In this retrospective cohort study, a total of 221 patients diagnosed with CRC from 2009 to 2015 at the Surgical and Oncological units of Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana were employed. The survival graphs were obtained …


The Role Of Adult Day Services In Supporting The Occupational Participation Of People With Dementia And Their Carers: An Integrative Review, Janice Du Preez, J. L. Millsteed, Ruth Marquis, Janet Richmond Jan 2018

The Role Of Adult Day Services In Supporting The Occupational Participation Of People With Dementia And Their Carers: An Integrative Review, Janice Du Preez, J. L. Millsteed, Ruth Marquis, Janet Richmond

Research outputs 2014 to 2021

The increasing numbers of people with dementia places considerable stress on health and aged care services and has resulted in the development of community adult day services. Aim: The aim of this integrative review is to determine the extent to which these services support the occupational participation of people with dementia, and how they impact their primary carers. Method: The mixed-methods appraisal tool (MMAT) was used to identify relevant studies in the period 2011–2016. Results: Nine databases were searched and yielded 16 articles with a variety of research designs for inclusion in the review. Conclusions: Findings …


Measuring The Prevalence Of Intradialytic Hypotension In A Satellite Dialysis Clinic: Are We Too Complacent?, Ulrich Steinwandel, Nick Gibson, Mandy Towell-Barnard, Richard Parsons, James J. R. Rippey, Johan Rosman Jan 2018

Measuring The Prevalence Of Intradialytic Hypotension In A Satellite Dialysis Clinic: Are We Too Complacent?, Ulrich Steinwandel, Nick Gibson, Mandy Towell-Barnard, Richard Parsons, James J. R. Rippey, Johan Rosman

Research outputs 2014 to 2021

Aims and objectives

To measure the prevalence of symptomatic (S‐IDH) and asymptomatic intradialytic hypotension (A‐IDH) or postdialysis overhydration in a satellite haemodialysis clinic in Western Australia.

Background

Intradialytic hypotension is one of the most common side effects of haemodialysis caused by ultrafiltration provoking a temporary volume depletion. The prevalence of asymptomatic hypotension during dialysis has been rarely reported, but is considered to have the same negative consequences as symptomatic hypotension on various end organs like the brain and the gastrointestinal tract.

Design

Observational study on a retrospective 3‐month period of nursing recorded fluid‐related adverse events.

Methods

Data collection on the …


Complex Training And Countermovement Jump Performance Across Multiple Sets: Effect Of Back Squat Intensity, Nick Poulos, Anic Chaouachi, Martin Buchheit, Denis Slimani, Greg Haff, Robert Newton Jan 2018

Complex Training And Countermovement Jump Performance Across Multiple Sets: Effect Of Back Squat Intensity, Nick Poulos, Anic Chaouachi, Martin Buchheit, Denis Slimani, Greg Haff, Robert Newton

Research outputs 2014 to 2021

The purpose of this investigation was to determine the acute effects of back squats on countermovement jump performance across multiple sets using a strength-power potentiation complex training protocol. Fifteen elite volleyball players performed three unloaded countermovement jumps (CMJ) following three repetitions of the back squat performed at either 65% or 87% of 1-RM, respectively, repeated for 10 sets. A control session of three CMJs was also repeated for 10 sets. Mean jump height performance was enhanced compared to performing CMJs only irrespective of which intensity was used (65% 1-RM: +3.3 ± 2.2% [CI: 1.0 to 5.6]; 87% 1-RM: 2.6 ± …


What Drives Food Insecurity In Western Australia? How The Perceptions Of People At Risk Differ To Those Of Stakeholders, Lucy M. Butcher, Maria M. Ryan, Therese A. O'Sullivan, Johnny Lo, Amanda Devine Jan 2018

What Drives Food Insecurity In Western Australia? How The Perceptions Of People At Risk Differ To Those Of Stakeholders, Lucy M. Butcher, Maria M. Ryan, Therese A. O'Sullivan, Johnny Lo, Amanda Devine

Research outputs 2014 to 2021

Food insecurity is considered a “wicked” problem due to the highly complex and at times undefined casual factors. Although many stakeholders are working to address the problem, a possible divergence exists between their views on food insecurity and those of the people who are actually experiencing the problem. The purpose of this study was to investigate whether there was a difference between the opinions of those “at risk” and stakeholders. A total of seven focus groups (two stakeholder groups n = 10, five “at-risk” groups n = 34) and three interviews (stakeholders n = 3) were conducted to ascertain perceptions. …


Minimally Actuated Walking: Identifying Core Challenges To Economical Legged Locomotion Reveals Novel Solutions, Ryan T. Schroeder, John Ea Bertram Jan 2018

Minimally Actuated Walking: Identifying Core Challenges To Economical Legged Locomotion Reveals Novel Solutions, Ryan T. Schroeder, John Ea Bertram

Research outputs 2014 to 2021

Terrestrial organisms adept at locomotion employ strut-like legs for economical and robust movement across the substrate. Although it is relatively easy to observe and analyze details of the solutions these organic systems have arrived at, it is not as easy to identify the problems these movement strategies have solved. As such, it is useful to investigate fundamental challenges that effective legged locomotion overcomes in order to understand why the mechanisms employed by biological systems provide viable solutions to these challenges. Such insight can inform the design and development of legged robots that may eventually match or exceed animal performance. In …


Unravelling Immunoglobulin G Fc N-Glycosylation: A Dynamic Marker Potentiating Predictive, Preventive And Personalised Medicine, Alyce Russell, Eric Adua, Ivo Ugrina, Simon Laws, Wei Wang Jan 2018

Unravelling Immunoglobulin G Fc N-Glycosylation: A Dynamic Marker Potentiating Predictive, Preventive And Personalised Medicine, Alyce Russell, Eric Adua, Ivo Ugrina, Simon Laws, Wei Wang

Research outputs 2014 to 2021

Multiple factors influence immunoglobulin G glycosylation, which in turn affect the glycoproteins’ function on eliciting an anti-inflammatory or pro-inflammatory response. It is prudent to underscore these processes when considering the use of immunoglobulin G N-glycan moieties as an indication of disease presence, progress, or response to therapeutics. It has been demonstrated that the altered expression of genes that encode enzymes involved in the biosynthesis of immunoglobulin G N-glycans, receptors, or complement factors may significantly modify immunoglobulin G effector response, which is important for regulating the immune system. The immunoglobulin G N-glycome is highly heterogenous; however, it is …


Can A Renal Nurse Assess Fluid Status Using Ultrasound On The Inferior Vena Cava? A Cross-Sectional Interrater Study: Ultrasound On The Inferior Vena Cava, Ulrich Steinwandel, Nicholas Gibson, Amanda Towell, James Rippey Jan 2018

Can A Renal Nurse Assess Fluid Status Using Ultrasound On The Inferior Vena Cava? A Cross-Sectional Interrater Study: Ultrasound On The Inferior Vena Cava, Ulrich Steinwandel, Nicholas Gibson, Amanda Towell, James Rippey

Research outputs 2014 to 2021

Introduction:

Ultrasound of the inferior vena cava (IVC-US) has been used to estimate intravascular volume status and fluid removal during a hemodialysis session. Usually, renal nurses rely on other, imprecise methods to determine ultrafiltration. To date, no study has examined whether renal nurses can reliably perform ultrasound for volume assessment and for potential prevention of intradialytic hypotension. This pilot study aimed to determine if a renal nurse could master the skill of performing and correctly interpreting Point of Care Ultrasound on patients receiving hemodialysis.

Methods:

After receiving theoretical training and performing 100 training scans, a renal nurse performed …


Effect Of Plyometric Training On Speed And Change Of Direction Ability In Elite Field Hockey Players, Jasdev Singh, Brendyn B. Appleby, Andrew P. Lavender Jan 2018

Effect Of Plyometric Training On Speed And Change Of Direction Ability In Elite Field Hockey Players, Jasdev Singh, Brendyn B. Appleby, Andrew P. Lavender

Research outputs 2014 to 2021

This study investigated the effects of two plyometric training protocols on sprint and change of direction (COD) performance in elite hockey players. A parallel-group randomized controlled trial design was used and seventeen elite male and female field hockey players were randomly allocated into either low-to-high (L-H, n = 8) or high-to-low (H-L, n = 9) training groups. Each group performed separate variations of the drop jump exercise twice weekly for six weeks, with an emphasis on either jump height (L-H) or drop height (H-L). Performance variables assessed included sprint times over 10 m and 20 m, as well as 505 …


Interpreting Signal Amplitudes In Surface Electromyography Studies In Sport And Rehabilitation Sciences, Andrew D. Vigotsky, Israel Halperin, Gregory J. Lehman, Gabriel S. Trajano, Taian M. Vieira Jan 2018

Interpreting Signal Amplitudes In Surface Electromyography Studies In Sport And Rehabilitation Sciences, Andrew D. Vigotsky, Israel Halperin, Gregory J. Lehman, Gabriel S. Trajano, Taian M. Vieira

Research outputs 2014 to 2021

Surface electromyography (sEMG) is a popular research tool in sport and rehabilitation sciences. Common study designs include the comparison of sEMG amplitudes collected from different muscles as participants perform various exercises and techniques under different loads. Based on such comparisons, researchers attempt to draw conclusions concerning the neuro- and electrophysiological underpinning of force production and hypothesize about possible longitudinal adaptations, such as strength and hypertrophy. However, such conclusions are frequently unsubstantiated and unwarranted. Hence, the goal of this review is to discuss what can and cannot be inferred from comparative research designs as it pertains to both the acute and …


Kibra Is Associated With Accelerated Cognitive Decline And Hippocampal Atrophy In Apoe Ε4-Positive Cognitively Normal Adults With High Aβ-Amyloid Burden, Tenielle Porter, Samantha Burnham, Vincent Doré, Greg Savage, Pierrick Bourgeat, Kimberly Begemann, Lidija Milicic, David Ames, Ashley Bush, Paul Maruff, Colin Masters, Christopher Rowe, Stephanie Rainey-Smith, Ralph Martins, David Groth, Guiseppe Verdile, Victor Villemagne, Simon Laws Jan 2018

Kibra Is Associated With Accelerated Cognitive Decline And Hippocampal Atrophy In Apoe Ε4-Positive Cognitively Normal Adults With High Aβ-Amyloid Burden, Tenielle Porter, Samantha Burnham, Vincent Doré, Greg Savage, Pierrick Bourgeat, Kimberly Begemann, Lidija Milicic, David Ames, Ashley Bush, Paul Maruff, Colin Masters, Christopher Rowe, Stephanie Rainey-Smith, Ralph Martins, David Groth, Guiseppe Verdile, Victor Villemagne, Simon Laws

Research outputs 2014 to 2021

A single nucleotide polymorphism, rs17070145, in the KIdney and BRAin expressed protein (KIBRA) gene has been associated with cognition and hippocampal volume in cognitively normal (CN) individuals. However, the impact of rs17070145 on longitudinal cognitive decline and hippocampal atrophy in CN adults at greatest risk of developing Alzheimer’s disease is unknown. We investigated the impact rs17070145 has on the rate of cognitive decline and hippocampal atrophy over six years in 602 CN adults, with known brain Aβ-amyloid levels and whether there is an interactive effect with APOE genotype. We reveal that whilst limited independent effects of KIBRA genotype …


Genetic Variation In Aquaporin-4 Moderates The Relationship Between Sleep And Brain Aβ-Amyloid Burden, Stephanie Rainey-Smith, Gavin N. Mazzucchelli, Victor L. Villemagne, Belinda M. Brown, Tenielle Porter, Michael Weinborn, Romola Bucks, Lidija Milicic, Hamid R. Sohrabi, Kevin Taddei, David J. Ames, Paul T. Maruff, Colin L. Masters, Christopher C. Rowe, Olivier Salvado, Ralph N. Martins, Simon M. Laws Jan 2018

Genetic Variation In Aquaporin-4 Moderates The Relationship Between Sleep And Brain Aβ-Amyloid Burden, Stephanie Rainey-Smith, Gavin N. Mazzucchelli, Victor L. Villemagne, Belinda M. Brown, Tenielle Porter, Michael Weinborn, Romola Bucks, Lidija Milicic, Hamid R. Sohrabi, Kevin Taddei, David J. Ames, Paul T. Maruff, Colin L. Masters, Christopher C. Rowe, Olivier Salvado, Ralph N. Martins, Simon M. Laws

Research outputs 2014 to 2021

The glymphatic system is postulated to be a mechanism of brain Aβ-Amyloid clearance and to be most effective during sleep. Ablation of the astrocytic end-feet expressed water-channel protein, Aquaporin-4, in mice, results in impairment of this clearance mechanism and increased brain Aβ-Amyloid deposition, suggesting that Aquaporin-4 plays a pivotal role in glymphatic function. Currently there is a paucity of literature regarding the impact of AQP4 genetic variation on sleep, brain Aβ-Amyloid burden and their relationship to each other in humans. To address this a cross-sectional observational study was undertaken in cognitively normal older adults from the Australian Imaging, Biomarkers and …


Properties Of Traditional Bamboo Carrying Poles Have Implications For User Interactions, Ryan T. Schroeder, James L. Croft, Giang D. Ngo, John E. A. Bertram Jan 2018

Properties Of Traditional Bamboo Carrying Poles Have Implications For User Interactions, Ryan T. Schroeder, James L. Croft, Giang D. Ngo, John E. A. Bertram

Research outputs 2014 to 2021

Compliant bamboo poles have long been used for load carriage in Asian cultures. Although this custom differs from Western conventions of rigid body attachments (e.g. backpack), potential benefits include reduced peak shoulder forces as well as metabolic transport cost savings. Evidence that carrying a flexible pole benefits locomotion remains mixed, perhaps in part because the properties of pole design (e.g. bamboo material, structural geometry, etc.) have largely been neglected. These properties influence vibrational forces and consequently, the energy required by the user to manage the oscillations. We collected authentic bamboo poles from northern Vietnam and characterized their design parameters. Four …


Effect Of Water Immersion Temperature On Heart Rate Variability Following Exercise In The Heat, Hui C. Choo, Kazunori Nosaka, Jeremiah J. Peiffer, Mohammed Ihsan, Chow C. Yeo, Chris R. Abbiss Jan 2018

Effect Of Water Immersion Temperature On Heart Rate Variability Following Exercise In The Heat, Hui C. Choo, Kazunori Nosaka, Jeremiah J. Peiffer, Mohammed Ihsan, Chow C. Yeo, Chris R. Abbiss

Research outputs 2014 to 2021

This study compared the effect of passive rest (CON) and water immersion at 8.6±0.2°C (CWI9), 14.6±0.3°C (CWI15) and 35.0±0.4°C (thermoneutral water immersion [TWI]) on post-exercise heart rate variability (HRV) indices. In a climate chamber (32.8±0.4°C, 32±5% relative humidity), nine men completed 25 min of cycling at the first ventilatory threshold and repeated 30-second bouts at 90% of peak power followed by a 5-minute recovery treatment in a randomised crossover manner. All water immersion re-established the HRV indices (natural logarithm of the square root of the mean sum squared differences between RR intervals [ln rMSSD], low-frequency [lnLF] and high-frequency power densities …


Association Of Wrist Circumference And Waist-To-Height Ratio With Cardiometabolic Risk Factors Among Type Ii Diabetics In A Ghanaian Population, Christian Obirikorang, Yaa Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Emmanuel Toboh, Evans Adu Asamoah, Bright Amakwaa, Emmanuella Nsenbah Batu, Peter Brenya Jan 2018

Association Of Wrist Circumference And Waist-To-Height Ratio With Cardiometabolic Risk Factors Among Type Ii Diabetics In A Ghanaian Population, Christian Obirikorang, Yaa Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Emmanuel Toboh, Evans Adu Asamoah, Bright Amakwaa, Emmanuella Nsenbah Batu, Peter Brenya

Research outputs 2014 to 2021

The study determined the association of wrist circumference (WrC) and waist-to-height ratio (WHtR) with cardiometabolic risk factors among diabetics in a Ghanaian population. This cross-sectional study involved 384 diabetic patients at Begoro District Hospital, Ghana. Blood pressure, anthropometrics, and biochemical indices were measured. The overall prevalence of dyslipidaemia, metabolic syndrome (MetS), and hypertension was 42.4%, 76.3%, and 39.8%, respectively. The optimum cut-off range of WrC to identify individuals at increased cardiometabolic risk was 17.5 to –17.8 cm for men and 16.0 to 16.7 cm for women while that of WHtR was 0.52 to 0.61 for men and 0.53 to 0.59 …


Metabolic Syndrome Among Schizophrenic Patients: A Comparative Cross-Sectional Study In The Middle Belt Of Ghana, Angela Owusu-Ansah, Anto Berko Panyin, Christian Obirikorang, Christian Agyare, Emmanuel Acheampong, Simon Kwofie, Enoch Odame Anto, Emmanuella Nsenbah Batu Jan 2018

Metabolic Syndrome Among Schizophrenic Patients: A Comparative Cross-Sectional Study In The Middle Belt Of Ghana, Angela Owusu-Ansah, Anto Berko Panyin, Christian Obirikorang, Christian Agyare, Emmanuel Acheampong, Simon Kwofie, Enoch Odame Anto, Emmanuella Nsenbah Batu

Research outputs 2014 to 2021

The study determined the prevalence ofMetS in patients with schizophrenia at the Psychiatric Unit of the Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana. This comparative cross-sectional study recruited 348 schizophrenic patients comprising 236 antipsychotic-treated and 112 newly diagnosed treatment-na¨ıve patients. The MetS prevalence was assessed based on World Health Organization (WHO), International Diabetes Federation (IDF), and the National Cholesterol Education Programme, Adult Treatment Panel III (NCEP ATP III) criteria. The overall prevalence of MetS was 14.1%, 20.4%, and 23.6% using NCEP ATP III, WHO, and IDF criteria, respectively, compared to 7.8%, 3.9%, and 2.2% reported in the generalGhanaian population.The prevalence …


Weight Loss Strategies In Combat Sports And Concerning Habits In Mixed Martial Arts, Oliver R. Barley, Dale W. Chapman, Chris Abbiss Jan 2018

Weight Loss Strategies In Combat Sports And Concerning Habits In Mixed Martial Arts, Oliver R. Barley, Dale W. Chapman, Chris Abbiss

Research outputs 2014 to 2021

Context:

Combat sports are typically divided into weight classes, and body-mass manipulation to reach a weight class is commonplace. Previous research suggests that weight loss practices in mixed martial arts (MMA) may be more extreme than in other combat sports.

Purpose:

To investigate the magnitude of weight loss and the prevalence of weight loss strategies in different combat sports.

Methods:

Competitors (N = 637) from Brazilian jiu-jitsu, boxing, judo, MMA, Muay Thai/kickboxing, taekwondo, and wrestling completed an online questionnaire seeking information regarding their weight loss practices.

Results:

Body-mass manipulation was commonly undertaken by all combat-sport athletes, …


Predictors Of Noncompliance To Antihypertensive Therapy Among Hypertensive Patients Ghana: Application Of Health Belief Model, Yaa Obirikorang, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Daniel Gyamfi, Selorm Philip Segbefia, Michael Opoku Boateng, Dari Pascal Dapilla, Peter Kojo Brenya, Bright Amankwaa, Evans Asamoah Adu, Emmanuel Nsenbah Batu, Adjei Gyimah Akwasi, Beatrice Amoah Jan 2018

Predictors Of Noncompliance To Antihypertensive Therapy Among Hypertensive Patients Ghana: Application Of Health Belief Model, Yaa Obirikorang, Christian Obirikorang, Emmanuel Acheampong, Enoch Odame Anto, Daniel Gyamfi, Selorm Philip Segbefia, Michael Opoku Boateng, Dari Pascal Dapilla, Peter Kojo Brenya, Bright Amankwaa, Evans Asamoah Adu, Emmanuel Nsenbah Batu, Adjei Gyimah Akwasi, Beatrice Amoah

Research outputs 2014 to 2021

This study determined noncompliance to antihypertensive therapy (AHT) and its associated factors in a Ghanaian population by using the health belief model (HBM). This descriptive cross-sectional study conducted at Kintampo Municipality in Ghana recruited a total of 678 hypertensive patients. The questionnaire constituted information regarding sociodemographics, a five-Likert type HBM questionnaire, and lifestyle-related factors. The rate of noncompliance to AHT in this study was 58.6%. The mean age (SD) of the participants was 43.5 (±5.2) years and median duration of hypertension was 2 years. Overall, the five HBM constructs explained 31.7% of the variance in noncompliance to AHT with a …


Bridging The Gap Between Clinicians And Fitness Professionals, Rachele Pojednic, Amy Bantham, Fred Arnstein, Mary A. Kennedy, Edward Phillips Jan 2018

Bridging The Gap Between Clinicians And Fitness Professionals, Rachele Pojednic, Amy Bantham, Fred Arnstein, Mary A. Kennedy, Edward Phillips

Research outputs 2014 to 2021

Objective Health clubs (HC) and personal trainers (PT) are traditional outlets for the promotion of physical activity (PA) and exercise programming. As physicians are increasingly being called on to write exercise prescriptions for their patients, this study sought to investigate the level of integration between the healthcare and fitness systems.

Design An internet study was designed with five domains to understand physicians’: (1) overall perception of HC, (2) appropriateness and recommendation of HC and PT to their patients, (3) attitude regarding specific aspects of HC, (4) support of patient participation in HC sponsored exercise and (5) elements of HC that …