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Full-Text Articles in Medicine and Health Sciences

Inhibition Of Tnf-Alpha Decreases Microglia Activation In Rats Neonatally Treated With Poly I:C, Heath W. Shelton, Russell W. Brown Apr 2018

Inhibition Of Tnf-Alpha Decreases Microglia Activation In Rats Neonatally Treated With Poly I:C, Heath W. Shelton, Russell W. Brown

Appalachian Student Research Forum

Introduction: Current medical treatment for individuals diagnosed with schizophrenia (SCHZ) primarily relies on the inhibition of the dopamine D2 receptor that has been shown to be supersensitive in these patients. Treatment occurs through the use of antipsychotic medication which leads to a number of debilitating dose-dependent side effects, such as weight gain, agranulocytosis, and seizures. Patients diagnosed with SCHZ have also been shown to have increased inflammation in their central nervous system (CNS), particularly within specific brain regions such as the prefrontal cortex and hippocampus. This is in large part due to the interaction between a pro-inflammatory cytokine called …


Association Between Alzheimer's Disease And Rural Northeast Tennessee Region Between 2013 And 2015, Sylvester Olubolu Orimaye, Jodi Southerland Apr 2018

Association Between Alzheimer's Disease And Rural Northeast Tennessee Region Between 2013 And 2015, Sylvester Olubolu Orimaye, Jodi Southerland

Appalachian Student Research Forum

Background: Alzheimer’s disease (AD) is a type of Dementia and a neurodegenerative disease that is characterized by the gradual degrading of both memory and cognitive functions. According to the World Health Organization (WHO), the prevalence of AD is increasing globally. Currently, AD is the sixth leading cause of mortality in the United States. As the ageing population increases in the United States, it is possible that AD will move up the ladder in the top cause of mortality. Although the prevalence of AD in most urban parts of developed nations such as the United States is widely known, little is …


Behavioral Correlates For Quitting Opioids Among Opioid-Dependent Pregnant And Non-Pregnant Women Of Childbearing Age In Rural Appalachia, Sindura Kompella, Sylvester Olubolu Orimaye, Nigel Dsouza, Karl Goodkin, Steven Kendell, Susan Wallace, Tracy Willson Apr 2018

Behavioral Correlates For Quitting Opioids Among Opioid-Dependent Pregnant And Non-Pregnant Women Of Childbearing Age In Rural Appalachia, Sindura Kompella, Sylvester Olubolu Orimaye, Nigel Dsouza, Karl Goodkin, Steven Kendell, Susan Wallace, Tracy Willson

Appalachian Student Research Forum

Background: The opioid epidemic is particularly worrisome in the pregnant population, wherein concerns are raised about the health of a mother and her child, resulting in an alarming incidence and prevalence of Neonatal Abstinence Syndrome (NAS). The 2016 National Survey on Drug Use and Health (NSDUH) show the rate of illicit psychoactive substance use among the females aged 12 or older was 15.5% in the past year. Among pregnant women aged 15 to 44, 6.3% were illicit psychoactive substance users. In Tennessee, the number of hospital discharged NAS cases from 2002 to 2013 increased from 1.50 to 16.6 cases per …