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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
A Review Of The Mechanism Of Antagonism Of N-Methyl-D-Aspartate Receptor By Ketamine In Treatment-Resistant Depression, Yasar Sattar, John Wilson, Ali M. Khan, Mahwish Adnan, Daniel Azzopardi Larios, Shristi Shrestha, Quazi Rahman, Zeeshan Mansuri, Ali Hassan, Nirav B. Patel
A Review Of The Mechanism Of Antagonism Of N-Methyl-D-Aspartate Receptor By Ketamine In Treatment-Resistant Depression, Yasar Sattar, John Wilson, Ali M. Khan, Mahwish Adnan, Daniel Azzopardi Larios, Shristi Shrestha, Quazi Rahman, Zeeshan Mansuri, Ali Hassan, Nirav B. Patel
School of Medicine Publications and Presentations
The biochemical processes involved in depression go beyond serotonin, norepinephrine, and dopamine. The N-methyl-D-aspartate (NMDA) receptor has a major role in the neurophysiology of depression. Ketamine, one of the prototypical NMDA antagonists, works rapidly in controlling depressive symptoms, including acutely suicidal behavior, by just a single injection. Ketamine may rapidly increase the glutamate levels and lead to structural neuronal changes. Increased neuronal dendritic growth may contribute to synaptogenesis and an increase in brain-derived neurotrophic factor (BDNF). Activation of the mechanistic target of rapamycin (mTOR), as well as increased levels of BDNF, may increase long-term potentiation and result in an improvement …
Reanalyzing The Activity Anorexia Protocol Using An Addiction Theory, Rolando Alfredo Botello
Reanalyzing The Activity Anorexia Protocol Using An Addiction Theory, Rolando Alfredo Botello
Theses and Dissertations
One researched and developed phenomenon is activity anorexia (AA) in rats and its resemblance to the human pathology anorexia nervosa (AN). Researchers have long relied on this comparative model for AN as AA. This study aims to reanalyze the overt physiological phenomena of AA to test an addictive theory against the prevalent AA theory. Equal numbers of subjects could eat or run during a one hour feeding period and all activity was monitored per 30 minutes. Results showed that daily running correlated with an increase in food consumption with no effect of food suppression. The only factor that regressed to …
Roller Derby As A Form Of Self-Empowerment: An Examination Of Female Athletes' Resilience To Intimate Partner Violence, Esmeralda Castillo
Roller Derby As A Form Of Self-Empowerment: An Examination Of Female Athletes' Resilience To Intimate Partner Violence, Esmeralda Castillo
Theses and Dissertations
The purpose of this study is to explore if playing roller derby can yield one more resilient to Intimate Partner Violence (IPV). IPV is a major wellness concern to our present lives. However, there are many who experience violence, yet do not develop debilitating symptoms. The subject of resilience has emerged to account for this. Resilience can be interpreted as “bouncing back” from adversity, and adapting well to sources of stress (American Psychological Association, n.d.). Sport psychologists have recognized sport as a site for the development of resilient qualities. For females, team sports offer a context to experience empowerment. The …
Principal Component Analysis Of Early Alcohol, Drug And Tobacco Use With Major Depressive Disorder In Us Adults, Kesheng Wang, Ying Liu, Youssoufou Ouedraogo, Nianyang Wang, Xin Xie, Chun Xu, Xingguang Luo
Principal Component Analysis Of Early Alcohol, Drug And Tobacco Use With Major Depressive Disorder In Us Adults, Kesheng Wang, Ying Liu, Youssoufou Ouedraogo, Nianyang Wang, Xin Xie, Chun Xu, Xingguang Luo
Health & Biomedical Sciences Faculty Publications and Presentations
Early alcohol, tobacco and drug use prior to 18 years old are comorbid and correlated. This study included 6239 adults with major depressive disorder (MDD) in the past year and 72,010 controls from the combined data of 2013 and 2014 National Survey on Drug Use and Health (NSDUH). To deal with multicollinearity existing among 17 variables related to early alcohol, tobacco and drug use prior to 18 years old, we used principal component analysis (PCA) to infer PC scores and then use weighted multiple logistic regression analyses to estimate the associations of potential factors and PC scores with MDD. The …
Analysis Of Ptprk Polymorphisms In Association With Risk And Age At Onset Of Alzheimer’S Disease, Cancer Risk, And Cholesterol, Yang Chen, Chun Xu, Sam Harirforoosh, Xingguang Luo, Ke-Sheng Wang
Analysis Of Ptprk Polymorphisms In Association With Risk And Age At Onset Of Alzheimer’S Disease, Cancer Risk, And Cholesterol, Yang Chen, Chun Xu, Sam Harirforoosh, Xingguang Luo, Ke-Sheng Wang
Health & Biomedical Sciences Faculty Publications and Presentations
The human receptor-type protein-tyrosine phosphatase kappa (PTPRK) gene is highly expressed in human brain and is previously associated with neuropsychiatric disorders and cancer. This study investigated the association of 52 single nucleotide polymorphisms (SNPs) in the PTPRK with the risk and age at onset (AAO) of Alzheimer’s disease (AD) in 791 AD patients and 782 controls. Five SNPs (top SNP rs4895829 with p=0.0125) were associated with the risk of AD based on a multiple logistic regression (p<0.05); while 6 SNPs (top SNP rs1891150 with p=8.02×10−6) were associated with AAO by using a multiple linear regression analysis. Interestingly, rs2326681 was associated with both the risk and AAO of AD (p=4.65×10−2 and 5.18×10−3, respectively). In a replication study, the results from family-based association test - generalized estimating equation (GEE) statistics and Wilcoxon test showed that seven SNPs were associated with the risk of AD (top SNP rs11756545 with p=1.02×10−2) and 12 SNPs were associated with the AAO (top SNP rs11966128 with p=1.39×10−4), respectively. One additional sample showed that four SNPs were associated with risk of cancer (top SNP rs1339197 with p=4.1×10−3), 12 SNPs associated with LDL-cholesterol (top SNP rs4544930 with p=3.47×10−3), and 8 SNPs associated with total cholesterol (top SNP rs1012049 with p=6.09×10−3). In addition, the AD associated rs4895829 was associated with the gene expression level in the cerebellum (p=7.3×10−5). The present study is the first study providing evidence of several genetic variants within the PTPRK gene associated with the risk and AAO of AD, risk of cancer, LDL and total cholesterol levels.