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Full-Text Articles in Medicine and Health Sciences
Stability And Compatibility Of Diphenhydramine Hydrochloride In Intravenous Admixtures: A New Look At An Old Drug, Daniel Sabins, Tuong Diep, Pamela Mccartan, Shashi Patel, Fang Zhao
Stability And Compatibility Of Diphenhydramine Hydrochloride In Intravenous Admixtures: A New Look At An Old Drug, Daniel Sabins, Tuong Diep, Pamela Mccartan, Shashi Patel, Fang Zhao
Doctoral External Publications
Purpose: Intravenous (IV) admixtures of diphenhydramine are widely used in hospitalized patients to prevent or treat hypersensitivity reactions. However, there is limited data to support the admixture preparation in this manner. This study was designed to investigate the stability and compatibility of diphenhydramine in IV admixtures with a goal to establish a 14-day beyond-use dating with storage under refrigeration. Methods: The commercially available 50 mg/mL diphenhydramine hydrochloride injection vials were used to prepare the 0.2 and 1.0 mg/mL IV admixtures in 0.9% sodium chloride injection and 5% dextrose injection in 50 mL polyvinyl chloride (PVC) bags. The IV bags were …
Pharmaceutical Care Management Association V. Rutledge, John J. Crean, Karl Williams
Pharmaceutical Care Management Association V. Rutledge, John J. Crean, Karl Williams
Doctoral External Publications
On June 8, 2018 the federal Eighth Circuit Court of Appeals announced its decision concerning Arkansas' attempt to regulate perceived unfair payment practices of pharmacy benefit managers (PBMs) in the case Pharmaceutical Care Management Association v. Rutledge.1 Because pharmacies across the country face similar problems, and this ruling may influence other federal appellate courts, review and discussion is useful for the purpose of making strategic decisions.
Stability Of Extemporaneously Prepared Sodium Benzoate Oral Suspension, Julia Atkins, Melinda E. Lull, Andrew S. Decker, David Hutchinson
Stability Of Extemporaneously Prepared Sodium Benzoate Oral Suspension, Julia Atkins, Melinda E. Lull, Andrew S. Decker, David Hutchinson
Doctoral External Publications
The stability of extemporaneously prepared sodium benzoate oral suspension in cherry syrup and Ora-Sweet was studied. Oral solutions of 250-mg/mL sodium benzoate were prepared in either cherry syrup or Ora-Sweet. To a beaker, 50 grams of Sodium Benzoate Powder USP was dissolved and filtered, the solution was divided equally into two parts, and each aliquot was added into two separate calibrated 100-mL amber vials. In the first vial, cherry syrup was added to make a final volume of 100 mL. In the second vial, Ora-Sweet was added to give a final volume of 100 mL. This process was repeated to …
Stability Of Extemporaneously Prepared Ophthalmic Solutions For Mydriasis, Nicole A. Camp, Jennifer T. Nadra, Susan E. Hughes, Justine M. Gilbert, Fang Zhao
Stability Of Extemporaneously Prepared Ophthalmic Solutions For Mydriasis, Nicole A. Camp, Jennifer T. Nadra, Susan E. Hughes, Justine M. Gilbert, Fang Zhao
Doctoral External Publications
Purpose Results of an evaluation of the physical and chemical stability of extemporaneously prepared adult and pediatric ophthalmic solutions containing combinations of phenylephrine, tropicamide, and cyclopentolate are reported.
Methods A stability study was conducted to help determine the feasibility of innovative formulations to meet an unmet clinical need for combination mydriatic ophthalmic eyedrops. An adult mydriatic ophthalmic solution containing phenylephrine hydrochloride 2.5% and tropicamide 1.0% and a pediatric formulation containing phenylephrine hydrochloride 2.5%, tropicamide 0.5%, and cyclopentolate hydrochloride 0.5% were prepared using proper aseptic techniques. Triplicate samples of each formulation were stored for 60 days at refrigeration temperatures (2–8 °C) …
Correlation Of Solid Dosage Porosity And Tensile Strength With Acoustically Extracted Mechanical Properties, Xiaochi Xu, Connor Mack, Zachary J. Cleland, Chaitanya Krishna Prasad Vallabh, Vivek S. Dave, Centin Cetinkaya
Correlation Of Solid Dosage Porosity And Tensile Strength With Acoustically Extracted Mechanical Properties, Xiaochi Xu, Connor Mack, Zachary J. Cleland, Chaitanya Krishna Prasad Vallabh, Vivek S. Dave, Centin Cetinkaya
Doctoral External Publications
Currently, the compressed tablet and its oral administration is the most popular drug delivery modality in medicine. The accurate porosity and tensile strength characterization of a tablet design is vital for predicting its performance such as disintegration, dissolution, and drug-release efficiency upon administration as well as ensuring its mechanical integrity. In current work, a non-destructive contact ultrasonic approach and an associated testing procedure are presented and employed to quantify and relate the acoustically extracted mechanical properties of pharmaceutical compacts to direct porosity and tensile strength measurements. Based on a comprehensive set of experimental data, it is demonstrated how strongly the …
Telepharmacy And The Law, Hailey Button, Karl Williams
Telepharmacy And The Law, Hailey Button, Karl Williams
Doctoral External Publications
Recently, an "Advisory Notice" was placed on the website of the New York State Board of Pharmacy entitled "Automated Dispensing Machines" that provide "drugs for sale to customers outside of their respective registered pharmacy areas", and that it "considers this to be a violation of state law"1. In support, the Notice cited the Education Law relating to the profession of pharmacy2 and Regulations of the Commissioner of Education3. Finally, ownership of the pharmacy and the Supervising Pharmacist are responsible for compliance and "may be subject to disciplinary and unprofessional conduct action". The Notice did not …