Medicine and Health Sciences Commons^™

Effect Of A Mixture Of Essential Oils And A Plant-Based Extract For The Management Of Localized Superficial Pyoderma In Dogs: An Open-Label Clinical Trial, Lerpen Duangkaew, Lawan Larsuprom, Chalermpol Lekcharoensuk, Charles Chen

The Thai Journal of Veterinary Medicine

A mixture of essential oils and a plant-based extract in the form of shampoo and spot-on were shown to have in vitro antimicrobial activity against Staphylococcus pseudintermedius. The purpose of this open-label clinical trial was to evaluate the efficacy of these two products for the management of canine localized superficial pyoderma. Twenty dogs diagnosed with 3-4 localized pyoderma lesions were enrolled. The dogs were bathed weekly for 8 weeks with shampoo and 48 hours later, spot-on was applied near the lesions. Clinical lesions and pruritus scores were subjectively assessed using a clinical improvement score system (1-5) and a pruritic visual …

Frontoethmoidal Meningoencephalocele With Multiple Congenital Craniofacial And Skeletal Malformations In A Stillborn Puppy, Promporn Raksaseri, Wuthichai Klomkleaw

The Thai Journal of Veterinary Medicine

A one-and-a-half-year-old Shih-Tzu bitch went into natural labor after full term of her first pregnancy, giving birth to 4 puppies. One of them was a male which died at birth, 104 grams in weight and 12 centimeters in length. This puppy showed several facial abnormalities and skeletal deformities. It was preserved in 10% formalin for anatomical, histopathological, and radiographic studies. Gross anatomical study revealed congenital anomalies of the eyes including anophthalmia of the left eye and microphthalmia of the right eye. Malformations of the ears including anotia of the left ear and microtia of the right ear were observed. Evidence …

Diagnostic Value Of Echocardiographic Indices And Cardiac Biomarkers In Dogs With Chronic Mitral Valve Insufficiency, Hyun-Seok Kim, Sang-Il Suh, Changbaig Hyun

The Thai Journal of Veterinary Medicine

Because all dogs having heart diseases are not in symptomatic heart failure stage, it is important to determine the stage of heart failure in dogs with heart diseases. Therefore, this study evaluated the diagnostic value of several echocardiographic parameters and cardiac biomarkers for differentiating dogs with heart disease from healthy dogs and dogs with symptomatic heart failure from dogs with asymptomatic heart failure. The study population consisted of 51 dogs having chronic mitral valvular insufficiency (CMVI) with varying degrees of heart failure and 18 healthy control dogs. Several echocardiographic parameters and cardiac biomarkers were evaluated to achieve the study aims. …

Osteopontin Is Linked With Akt, Foxo1, And Myostatin In Skeletal Muscle Cells, Peter P. Nghiem, Joe N. Kornegay, Kitipong Uaesoontrachoon, Luca Bello, Ying Yin, Akanchha Kesari, Priya Mittal, Scott J. Schatzberg, Gina M. Many, Norman H. Lee, Eric P. Hoffman

All Faculty Scholarship for the College of the Sciences

Introduction: Osteopontin (OPN) polymorphisms are associated with muscle size and modify disease progression in Duchenne muscular dystrophy (DMD). We hypothesized that OPN may share a molecular network with myostatin (MSTN).

Methods: Studies were conducted in the golden retriever (GRMD) and mdx mouse models of DMD. Follow-up in-vitro studies were employed in myogenic cells and the mdx mouse treated with recombinant mouse (rm) or human (Hu) OPN protein.

Results: OPN was increased and MSTN was decreased and levels correlated inversely in GRMD hypertrophied muscle. RM-OPN treatment led to induced AKT1 and FoxO1 phosphorylation, microRNA-486 modulation, and decreased MSTN. An AKT1 inhibitor …

Surgical Treatment Of Spontaneous Pneumothorax Associated With Lobal Emphysema In A Dog, Yawon Hwang, Seungwon Yoo, Gonhyung Kim

The Thai Journal of Veterinary Medicine

A 3-year-old female Maltese dog was admitted with cough, dyspnea, and gasping. There was no sign of trauma in history taking. It was speculated that pneumothorax occurred in the right pleural space after X-ray examination. Thoracocentesis and chest tube were applied for 5 days. The symptoms of dyspnea and cough were, however, not relieved or recurred. Exploratory thoracotomy was considered to be the most appropriate approach. Spongiform and air-containing tissue was identified in the whole parenchyma in the right middle lobe. Total lobectomy was performed and then a chest tube was inserted. Atrophy of the right cranial lobe and collapse …

Effects Of Cryopreservation And Leukodepletion On Morphological Index Of Red Blood Cells In Dogs, Deniz Aktaran Bala, Ibrahim Akyazi

The Thai Journal of Veterinary Medicine

Preservation of blood components for transfusion is a long-standing phenomenon. However, studies of cryopreservation of leukodepleted canine erythrocytes are quite limited and no studies are available with respect to morphological evaluation of erythrocytes during the cryopreservation process. The aim of this study was to determine morphological changes caused by cryopreservation, storage and leukocyte filtration. Healthy adult dogs meeting the criteria for blood transfusion were used in this study. Packed red blood cells (pRBCs) were obtained from each dog. The samples were divided into two groups. Leukocyte filtration was performed on one group of pRBCs. The other group received no filtration. …

Depression, Loneliness, And Pet Attachment In Homebound Older Adult Cat And Dog Owners, Sandy M. Branson, Lisa Boss, Stanley Cron, Dennis C. Turner

Journal of Mind and Medical Sciences

Background: Companion animals may reduce depression and loneliness in socially isolated homebound older adults. However, whether owning a cat or dog is more beneficial in this population remains unknown.

Materials and Methods: Pet attachment and the levels of depressive symptoms and loneliness were examined in 39 homebound older adults who exclusively owned a cat(s) or a dog(s). Cat owners (n = 12) and dog owners (n=27) were assessed for depressive symptoms (Geriatric Depression Scale-Short Form), loneliness (R-UCLA Loneliness Scale), and attachment to pets (Likert scale).

Results: Cat owners reported significantly lower levels of depressive symptoms than dog …

Relationships Between Transferrin And Transferrin Receptor (Tfr) Expression In Dogs With Malignant Oronasal Tumors, Sekkarin Ploypetch, Anudep Rungsipipat, Prapruddee Piyaviriyakul, Nan Choisunirachon, Pussadee Makoom, Chanin Kalpravidh

The Thai Journal of Veterinary Medicine

Malignant cells require a large amount of iron for cell growth. Transferrin transfers iron from blood to cells by reacting with transferrin receptor (TfR). In humans, transferrin and transferrin receptor correlate with oral squamous cell carcinoma (OSCC); however, the association with canine oral tumor has not been studied. This study aimed to investigate saliva and serum transferrin and tissue transferrin receptor in canine OSCC and oral melanoma (OM). Saliva and serum transferrin samples were collected pre- and 14 days post-operation, compared with healthy control and evaluated by a sandwich ELISA assay. Serum transferrin concentration in the experimental group both before …

Effects Of Ivabradine On Left Ventricular Function In Dogs With Congestive Heart Failure, Sajika Sri-Ngam, Soontaree Petchdee

The Thai Journal of Veterinary Medicine

Ivabradine is an essential drug administered in current standard therapy for human heart failure and is expected to be beneficial to congestive heart failure dog. Ivabradine is a selective If Channel inhibitor. It reduces cardiac pacemaker activity and slows heart rate. There are a few reports of ivabradine in veterinary applications. The aim of this study was to investigate the effects of ivabradine on left ventricular function in dogs with congestive heart failure. Thirteen client-owned dogs with systolic and/or diastolic heart failure were included in this study. The dogs were assigned to two groups: (i) the active control group, given …

Aβ Vaccination In Combination With Behavioral Enrichment In Aged Beagles: Effects On Cognition, Aβ, And Microhemorrhages, Paulina R. Davis, Ginevra Giannini, Karin Rudolph, Nathaniel Calloway, Christopher M. Royer, Tina L. Beckett, M. Paul Murphy, Frederick Bresch, Dieter Pagani, Thomas Platt, Xiaohong Wang, Amy Skinner Donovan, Tiffany L. Sudduth, Wenjie Lou, Erin L. Abner, Richard J. Kryscio, Donna M. Wilcock, Edward G. Barrett, Elizabeth Head

Sanders-Brown Center on Aging Faculty Publications

Beta-amyloid (Aβ) immunotherapy is a promising intervention to slow Alzheimer’s disease (AD). Aging dogs naturally accumulate Aβ and show cognitive decline. An active vaccine against fibrillar Aβ 1–42 (VAC) in aged beagles resulted in maintenance but not improvement of cognition along with reduced brain Aβ. Behavioral enrichment (ENR) led to cognitive benefits but no reduction in Aβ. We hypothesized cognitive outcomes could be improved by combining VAC with ENR in aged dogs. Aged dogs (11–12 years) were placed into 4 groups: (1) control/control (C/C); (2) control/VAC (C/V); (3) ENR/control (E/C); (4) ENR and VAC (E/V) and treated for 20 months. …

First Clinical Strongyloides Stercoralis Case In A Dog In Turkey, Şi̇nasi̇ Umur, Yücel Meral, Cenk Soner Bölükbaş, Ali̇ Tümay Gürler, Mustafa Açici

Turkish Journal of Veterinary & Animal Sciences

A 2.5-year-old small male Cavalier King Charles spaniel was brought to Ondokuz Mayıs University's Faculty of Veterinary Medicine Animal Hospital with symptoms of severe watery diarrhea, pain during defecation, intermittent cough, vomiting, and emaciation. Examination of the fecal smear revealed moderate infection of Strongyloides stercoralis larvae and two adult females. Counting of the larvae in feces was performed by Baermann method and 20 larvae were determined per gram of feces. The dog was treated with ivermectin (Avromec, 0.2 mg/kg subcutaneously) and multivitamin syrup (Vitabiol) for 5 days for supporting the body condition. This paper is the first clinical case report …

Thromboelastographic Evaluation Of Hemostatic Functionin Dogs With Dilated Cardiomyopathy, Zeki̇ Yilmaz, Meri̇ç Kocatürk, Oya Eralp İnan, Pinar Levent

Turkish Journal of Veterinary & Animal Sciences

This study aimed to evaluate the hemostatic function by thromboelastography (TEG) and determine if there was an association between the changes in hemostatic parameters and serum cardiac troponin I (cTnI) in dogs with dilated cardiomyopathy (DCM). DCM was diagnosed by echocardiography in 19 dogs. Ten healthy dogs were selected as controls. Myocardial injury was confirmed by increased serum cTnI levels. Coagulation was assessed by TEG evaluating clot kinetics (reaction time [R] and kinetic time [K]), clot strengthening (alpha [α] angle and G value), platelet function (maximum amplitude [MA] and coagulation-index [CI]), clot stability (LY30, the percentage of lysis 30 min …

Fascia Lata Flap To Repair Perineal Hernia In Dogs: A Preliminary Study, Simone Guérios, Juliana Monteiro, Daniella Matos Da Silva

Turkish Journal of Veterinary & Animal Sciences

Perineal hernia (PH) in dogs normally requires surgical reconstruction of the pelvic diaphragm. The use of fascia lata grafts has been reported and described in previous studies for the correction of PH after failure of the conventional herniorrhaphy. The purpose of this report is to describe a modified technique of fascia lata flap (FLP) for PH repair in dogs. Six client-owned male dogs with PH were included in the study. PH was repaired with a FLP obtained from the dog's ipsilateral thigh and sutured directly into the perineal defect. Caudal scrotal orchiectomy was performed in all dogs that were not …