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Full-Text Articles in Medicine and Health Sciences
Recipients’ Perspectives Regarding Expanded Carrier Screening Of Gamete Donors, Erika Kristy Jackson
Recipients’ Perspectives Regarding Expanded Carrier Screening Of Gamete Donors, Erika Kristy Jackson
Theses and Dissertations
Purpose: This study explored the perspectives of intended parents regarding genetic carrier screening of a gamete donor. The main goal of this study was to determine how much genetic carrier screening information a recipient would prefer to receive about potential donors. The study also aimed to identify factors that potentially influence a recipient’s choice of donor based on genetic screening results. Methods: An online questionnaire was developed to assess intended parents’ preferences regarding expanded carrier screening (ECS) of their donors. Participants were recruited from various online support groups and were eligible if they had previously utilized or were currently utilizing …
Pediatric Genetic Counselor Perspective On Serving The Foster Care Population And The Integration Of Genetic Information Within The Health Passport, Angela Rose Douglas
Pediatric Genetic Counselor Perspective On Serving The Foster Care Population And The Integration Of Genetic Information Within The Health Passport, Angela Rose Douglas
Theses and Dissertations
Many states within the foster care system have adopted a document referred to as the health passport, which provides a condensed summary of a child's health history. This passport is intended to remain with the child as he/she moves between placements to improve communication between foster parents, caseworkers, and medical professionals. This exploratory research study examines the foster care system's utility of a child's health passport and opportunities for improvement through an online survey of the pediatric genetic counselor population. First, counselor perspectives on serving foster children were gathered and summarized into themes. Major elements and/or obstacles of counseling the …
Mast Cells And Lipid Cross-Talk In Skin Inflammation, Piper Alexandra Wedman
Mast Cells And Lipid Cross-Talk In Skin Inflammation, Piper Alexandra Wedman
Theses and Dissertations
Atopic dermatitis (AD) is an inflammatory skin disease whose pathogenic mechanisms remain unclear. Using a validated human AD-like mouse model, we observed that skin remodeling started at a pre-symptomatic stage of AD that included cellular infiltration of the hypodermis, accompanied with activated/degranulated mast cells (MC). Local MC activation was quantified using a novel method of computer-assisted image analysis we developed and reported. Using a variation of this method, we defined morphometric parameters allowing for quantitation rather than scoring of cellular infiltration. Cell recruitment correlated with MC activation, chemokine production and increased levels of sphingolipid sphingosine-1-phosphate (S1P), produced by sphingosine kinase-1 …