Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2016

Series

Thomas Jefferson University

Discipline
Publication

Articles 1 - 30 of 63

Full-Text Articles in Medicine and Health Sciences

3 Million Downloads For The Jefferson Digital Commons, Daniel G. Kipnis, Msi Dec 2016

3 Million Downloads For The Jefferson Digital Commons, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

On December 14, 2016 the Jefferson Digital Commons reached a new milestone by passing the 3 million download mark along with the deposit of more than 12,000 assets to date.


Delay Discounting Of Pregnancy- And Condom-Protected Sex Among Methadone-Maintained Women, Dennis J. Hand, Phd, Lindsay Reid, Diane J. Abatemarco, Msw, Phd Dec 2016

Delay Discounting Of Pregnancy- And Condom-Protected Sex Among Methadone-Maintained Women, Dennis J. Hand, Phd, Lindsay Reid, Diane J. Abatemarco, Msw, Phd

Department of Obstetrics and Gynecology Presentations and Grand Rounds

Introduction

  • Over 80% of pregnancies are unintended among women with opioid use disorder (OUD; Heil et al., 2011).
  • Use of effective contraception is uncommon in this population (Terplan et al., 2015).
  • Initiating and using effective contraception involves delays: to obtain the method from a provider, to become protected after initiating use.
  • Interventions that include delay reductions among other elements have increased contraceptive use (Heil et al., 2016; Secura et al., 2014).
  • Women with OUD have reported greater likelihood of engaging in unprotected sex at shorter delays to acquiring protection from sexually-transmitted infection (STI) than women without OUD (Herrmann et al., …


A Word From The Writing Center (December 2016), Jennifer Wilson, Ms, Els Dec 2016

A Word From The Writing Center (December 2016), Jennifer Wilson, Ms, Els

A Word From the Writing Team (Newsletter)

This issue includes:

  • Writing tip
  • Books on writing
  • Writing Café


A Word From The Writing Center (November 2016), Jennifer Wilson, Ms, Els Nov 2016

A Word From The Writing Center (November 2016), Jennifer Wilson, Ms, Els

A Word From the Writing Team (Newsletter)

November 2016 issue includes:

  • Writing Tip
  • Learning Opportunity
  • Writing Café


Getting Started: Identifying Funding Opportunities With Jefferson Resources, Molly Gerber, Avp, Gary Kaplan, Dana Marcus Nov 2016

Getting Started: Identifying Funding Opportunities With Jefferson Resources, Molly Gerber, Avp, Gary Kaplan, Dana Marcus

Department of Surgery, Faculty Development Sessions

Section 1: Philanthropy Basics

Section 2: Fundraising for Research

Section 3: Information Resources

36 PowerPoint slides


Jefferson Digital Commons Quarterly Report: July-September 2016, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi, James Copeland, Libt Oct 2016

Jefferson Digital Commons Quarterly Report: July-September 2016, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi, James Copeland, Libt

Jefferson Digital Commons Reports

Highlights in this quarterly report include:

  • Class Day programs from 1964-2015
  • Commencement programs from the Medical College from 1870 to the present.
  • Commencement programs from College of Graduate Studies
  • Readership download map for the quarter
  • Top 10 government and education domains accessing content in the JDC
  • What people are saying about the Jefferson Digital Commons


Emerging Infectious Diseases: Global To Local Implications, Mary Lou Manning, Phd, Crnp, Cic, Faan Oct 2016

Emerging Infectious Diseases: Global To Local Implications, Mary Lou Manning, Phd, Crnp, Cic, Faan

Department of Nursing Papers

Infectious disease remains among the leading causes of death worldwide. With easy mobility and air travel, pathogens can move quickly and silently to any place around the globe in a matter of days. The recent Ebola crises in West Africa clearly demonstrated the increased risk of emerging infections in our highly connected world. Legal nurse consultants are well-positioned to provide guidance on deciphering public health laws relevant to responding to infectious disease threats.


Are Researchers Registering Systematic Reviews In Clinicaltrials.Gov?, Gary E. Kaplan, Ms, Ahip Sep 2016

Are Researchers Registering Systematic Reviews In Clinicaltrials.Gov?, Gary E. Kaplan, Ms, Ahip

Academic Commons and Scott Memorial Library Staff Papers and Presentations

BACKGROUND:

ClinicalTrials.gov (CT) is an increasingly important resource for systematic reviewers attempting to identify published and unpublished clinical studies. In addition to clinical studies, however, some searches of the CT database also return systematic reviews (SRs). When I inquired about the SRs appearing in the results, the NLM Help Desk responded that “We do not recommend that systematic reviews be entered in ClinicalTrials.gov, since we only want the results of a clinical trial entered once. However, we will not refuse them if they are entered.” I wanted to find out how many SRs are included, describe their characteristics, and suggest …


Therapeutic Interventions For The Treatment Of Infants Exposed To Drugs And Alcohol In Utero, Faigie Bier, Ots, Elizabeth Fenn, Ots, Angela Kochobay, Ots, Katie Moran, Ots, Kavita Naik, Ots Aug 2016

Therapeutic Interventions For The Treatment Of Infants Exposed To Drugs And Alcohol In Utero, Faigie Bier, Ots, Elizabeth Fenn, Ots, Angela Kochobay, Ots, Katie Moran, Ots, Kavita Naik, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus (Complete): Children and Youth

Learning Objectives (Provide 3 learning objectives):

At the conclusion of the session, the learner will be able to:

  1. Identify areas of occupational performance that are affected when an infant is born with Neonatal Abstinence Syndrome or Fetal Alcohol Spectrum Disorder.
  2. Recognize the importance of therapeutic interventions in promoting healthy development and participation of infants within the scope of practice for occupational therapy.
  3. Apply evidence-based occupational therapy interventions for infants with Neonatal Abstinence Syndrome (NAS) or Fetal Alcohol Spectrum Disorders (FASD).

Abstract:

In the United States, approximately 0.2-1.5 per 1,000 infants are …


Occupational Therapy Interventions For Activities Of Daily Living In Adults With Osteoarthritis, Amanda Gilroy, Ots, Anna Guthrie, Ots, Tierney Guido, Ots, Maura Iacobucci, Ots Aug 2016

Occupational Therapy Interventions For Activities Of Daily Living In Adults With Osteoarthritis, Amanda Gilroy, Ots, Anna Guthrie, Ots, Tierney Guido, Ots, Maura Iacobucci, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus: Productive Aging

Learning Objectives:

At the end of this presentation, participants will be able to:

  1. Describe the clinical presentation of osteoarthritis and three ways it impacts Activities of Daily Living (ADL) performance
  2. Recognize the value of an Occupational Therapy intervention in addition to surgical and pharmacological interventions for osteoarthritis
  3. Identify at least three current evidence based practice interventions for improving ADL performance for people with osteoarthritis

Abstract:

Currently, 30.8 million Americans have diagnoses of osteoarthritis (OA) and the number of individuals with arthritis is projected to increase to 78 million by 2040 (CDC, 2016). Health care costs for …


Fall Prevention Interventions For Community-Dwelling Older Adults, Monica Heacock, Ots, Erin Kelly, Ots, June Park, Ots, Alex Muscella, Ots, Tony Thierolf, Ots Aug 2016

Fall Prevention Interventions For Community-Dwelling Older Adults, Monica Heacock, Ots, Erin Kelly, Ots, June Park, Ots, Alex Muscella, Ots, Tony Thierolf, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus: Productive Aging

Learning Objectives:

At the conclusion of the session, the learner will be able to: 1. Recognize the impact of falls on community-dwelling older adults

2. Describe ways to include fall prevention interventions into current clinical practice

3. Discuss benefits of preventative interventions in regards to current healthcare trends

Abstract: According to the Centers for Disease Control and Prevention (CDC), older adults (65+ years) are the largest growing population in the United States which comprises 14.5% of the total population (CDC, 2015). This population is estimated to almost double by 2030 to approximately 71 million Americans over …


You’Ve Got Time: Occupational Therapy’S Role In The Juvenile Justice System, Monica Dasgupta, Ots, Jenna Hannan, Ots, Helena Riekena, Ots, Samantha Susson, Ots Aug 2016

You’Ve Got Time: Occupational Therapy’S Role In The Juvenile Justice System, Monica Dasgupta, Ots, Jenna Hannan, Ots, Helena Riekena, Ots, Samantha Susson, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus: Children and Youth

Learning Objectives:

  1. State one economic and two population health implications of juvenile incarceration in the United States.
  2. Identify two occupation-based interventions implemented in the juvenile justice system.
  3. Recognize two areas of opportunity for occupational therapy intervention in the juvenile justice system to promote occupational justice and reduce recidivism.

Abstract:

This is an introductory level presentation for occupational therapists (OTs), occupational therapy assistants, and students intended to provide insight to areas of opportunity for OT intervention to reduce recidivism in the juvenile justice system. A systematic review of the literature was conducted to answer the …


Losing A Limb, Regaining Independence: A Systematic Review Of Occupational Therapy Interventions For Lower Extremity Amputations, Davis Berzins, Ots, Jennifer Cohen, Ots, Jamie A. Frank, Ots, Gabrielle Kirk, Ots, Jennifer Mitchell, Ots Aug 2016

Losing A Limb, Regaining Independence: A Systematic Review Of Occupational Therapy Interventions For Lower Extremity Amputations, Davis Berzins, Ots, Jennifer Cohen, Ots, Jamie A. Frank, Ots, Gabrielle Kirk, Ots, Jennifer Mitchell, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus:

Rehab, Disability & Participation

Learning Objectives:

  1. Describe lower extremity residual limb care interventions within the scope of occupational therapy
  2. Explain the prevalence of individuals who sustain a lower extremity amputation and understand the impact on the U.S. health-care system
  3. Identify lower extremity residual limb care interventions to maximize occupational performance

Abstract:

The purpose of this presentation is to report findings of a systematic review regarding residual limb care interventions supporting increased occupational performance in adults post lower extremity amputation. A systematic review was completed utilizing PubMed, CINHAL, and OTseeker. Inclusion criteria included articles with a sample of adults …


Retrain Your Brain: A Systematic Review Of Functional Electrical Stimulation’S Effect On Adl Participation Post-Stroke, Alyssa Brief, Ots, Jimmy Cassel, Ots, Rachael Kaufman, Ots, Caitlin Knudsen, Ots, Sharon Krause, Ots Aug 2016

Retrain Your Brain: A Systematic Review Of Functional Electrical Stimulation’S Effect On Adl Participation Post-Stroke, Alyssa Brief, Ots, Jimmy Cassel, Ots, Rachael Kaufman, Ots, Caitlin Knudsen, Ots, Sharon Krause, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus: Rehab, Disability & Participation Learning Objectives:

Learning Objectives:

● Describe the impact of stroke on ADL performance

● Identify the role of OT in stroke rehabilitation

● Explain how Functional Electrical Stimulation (FES) falls within the scope of OT practice

● Interpret the current evidence on how FES influences ADL participation for individuals poststroke

Abstract:

Stroke is one of the leading causes of long term disability in the United States (Centers for Disease Control and Prevention, 2015). According to HartmanMaeir, Soroker, Ring, Avni, and Katz (2007), 57% of stroke survivors will eventually discontinue their meaningful activities, including activities …


Can I Have Your Attention? (And Keep It): Interventions To Improve Executive Function Skills In Children Post-Traumatic Brain Injury, Brianna Clee, Ots, Brianna Fecondo, Ots, Sara Johnson, Ots, Catherine Misczak, Ots Aug 2016

Can I Have Your Attention? (And Keep It): Interventions To Improve Executive Function Skills In Children Post-Traumatic Brain Injury, Brianna Clee, Ots, Brianna Fecondo, Ots, Sara Johnson, Ots, Catherine Misczak, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus: Children and Youth

Secondary Focus: Rehab, Disability, & Participation

Learning Objectives:

*Objective 1: Identify and recognize the clinical need of the pediatric traumatic brain injury population in regards to OT practice.

*Objective 2: Interpret presented findings to identify 2-3 of the most effective interventions for desired outcomes for this population.

*Objective 3: Differentiate opportunities and barriers to implementing effective executive functioning interventions in current occupational therapy practice.

Abstract:

Traumatic brain injuries are a frequent source of disability within the pediatric population with estimates of 500:100,00 children in America experiencing an injury each year (Anderson et al., 2012). …


Not Just A “Touch Of The Sugars”: The Use Of Occupational Therapy Interventions To Promote Independence In Diabetes Self-Management, Eric Bull, Ots, Juliana Sullivan, Ots, Jenna Devaney, Ots, Jillian Fader, Ots, Kathleen Sheppard, Ots Aug 2016

Not Just A “Touch Of The Sugars”: The Use Of Occupational Therapy Interventions To Promote Independence In Diabetes Self-Management, Eric Bull, Ots, Juliana Sullivan, Ots, Jenna Devaney, Ots, Jillian Fader, Ots, Kathleen Sheppard, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus: Health & Wellness

Secondary Focus: General & Professional Issues

Learning Objectives:

At the end of this presentation, participants will:

Objective 1: Define the scope of self-management in relation to diabetes care.

Objective 2: Describe how the prevalence of diabetes and complications from mismanagement impact the United States healthcare system.

Objective 3: Identify 2-3 ways in which occupational therapists can facilitate diabetes self-management in clinical practice to promote health and wellness.

Abstract:

In the United States (U.S.), 29.1 million people have diabetes mellitus (DM) (Centers for Disease Control and Prevention [CDC], 2014) and the cost of diabetes care …


Aging In Place: Technology And Independence For Community-Dwelling Older Adults, Mikael Avery, Ots, Devon Barber, Ots, Maggie Derstine, Ots, Clarice Licon, Ots Aug 2016

Aging In Place: Technology And Independence For Community-Dwelling Older Adults, Mikael Avery, Ots, Devon Barber, Ots, Maggie Derstine, Ots, Clarice Licon, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus: Productive Aging

Learning Objectives:

By the end of this presentation, participants will be able to:

  1. Explain the rationale for the use of technology-based interventions for community-dwelling older adults.
  2. Describe three current technologies that can be used to positively impact occupational performance for community-dwelling older adults.
  3. Describe the barriers to successful implementation of technology-based interventions for community-dwelling older adults.

Abstract:

The population of older adults in the U.S. continues to rise, as does the desire to remain in one’s own home, a concept known as “aging in place” (Piau, Campo, Rumeau, Vellas, & Nourhashémi, 2014; Centers …


Occupational Therapy In Preventative Care: Promoting Cardiovascular Health In Underserved Women, David Goldstein, Ots, Rachel Marlow, Ots, Katherine Nelson, Ots, Megan Smith, Ots, Phoi Truong, Ots Aug 2016

Occupational Therapy In Preventative Care: Promoting Cardiovascular Health In Underserved Women, David Goldstein, Ots, Rachel Marlow, Ots, Katherine Nelson, Ots, Megan Smith, Ots, Phoi Truong, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Primary Focus:

Health & Wellness

Level of session: intermediate, mixed audience

Learning Objectives:

By the conclusion of this presentation, participants will:

Describe how health disparities affect underserved women

Identify evidence supporting the inclusion of occupational therapy in preventative care practice

Discuss occupational therapy’s role in preventative care as it relates to cardiovascular health and wellness

Abstract:

Heart disease causes one in three deaths each year in women (AHA, 2012). Increasing healthcare costs disproportionately affect women with low incomes and those from diverse backgrounds (CHUW, 2012). For underserved women, lack of insurance, education and variations in culture may compromise …


What's New In Musculoskeletal Infection: Update On Biofilms., Arvind Nana, Sandra B Nelson, Alex Mclaren, Antonia F. Chen, Md, Mba Jul 2016

What's New In Musculoskeletal Infection: Update On Biofilms., Arvind Nana, Sandra B Nelson, Alex Mclaren, Antonia F. Chen, Md, Mba

Rothman Institute Faculty Papers

No abstract provided.


Bibliography Of Secondary Sources On The History Of Dermatology Ii. Obituaries And Biographies In English Supplemented Through 2015, Sarah Brenner, Md (Editor), Lawrence Parish, Md, Michael J. Lavery, Mb Bch Bao; Mrcp, Andrzej Grzybowski, Md, Phd, Jennifer L. Parish, Md, Daniel H. Parish, Md, Jd Jul 2016

Bibliography Of Secondary Sources On The History Of Dermatology Ii. Obituaries And Biographies In English Supplemented Through 2015, Sarah Brenner, Md (Editor), Lawrence Parish, Md, Michael J. Lavery, Mb Bch Bao; Mrcp, Andrzej Grzybowski, Md, Phd, Jennifer L. Parish, Md, Daniel H. Parish, Md, Jd

Department of Dermatology and Cutaneous Biology Faculty Papers

Introduction

A bibliographic record on the history of dermatology has been a project that started over 4 decades ago. It is a collection of all forms of history, ranging from dermatologic conditions, to famous dermatologists and physicians who have advanced the field of both dermatology and medicine, to the different countries that promoted the development of scientists, researchers and physicians alike.

It was decided that the bibliographic record would encompass journals, books and a compilation of obituaries. A pertinent question is whether a manually created bibliographic project is still warranted in the 21st century. In short, yes. While Index …


Bibliography Of Secondary Sources On The History Of Dermatology, Sarah Brenner, Md (Editor), Lawrence Parish, Md, Michael J. Lavery, Mb Bch Bao; Mrcp, Andrzej Grzybowski, Md, Phd, Jennifer L. Parish, Md, Daniel H. Parish, Md, Jd Jul 2016

Bibliography Of Secondary Sources On The History Of Dermatology, Sarah Brenner, Md (Editor), Lawrence Parish, Md, Michael J. Lavery, Mb Bch Bao; Mrcp, Andrzej Grzybowski, Md, Phd, Jennifer L. Parish, Md, Daniel H. Parish, Md, Jd

Department of Dermatology and Cutaneous Biology Faculty Papers

Introduction

A bibliographic record on the history of dermatology has been a project that started over 4 decades ago. It is a collection of all forms of history, ranging from dermatologic conditions, to famous dermatologists and physicians who have advanced the field of both dermatology and medicine, to the different countries that promoted the development of scientists, researchers and physicians alike.

It was decided that the bibliographic record would encompass journals, books and a compilation of obituaries. A pertinent question is whether a manually created bibliographic project is still warranted in the 21st century. In short, yes. While Index …


Jefferson Digital Commons Quarterly Report: April-June 2016, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi, James Copeland, Libt Jul 2016

Jefferson Digital Commons Quarterly Report: April-June 2016, Daniel G. Kipnis, Msi, Kelsey Duinkerken, Msi, James Copeland, Libt

Jefferson Digital Commons Reports

This quarterly report includes:

  • TJU Archives & Special Collections Adds Content to the DPLA
  • JDC Feature write-up in The Bulletin and JCIPE Newsletter
  • New Dashboard with amazing metrics
  • 8th Annual Faculty Day presentations
  • Surgery Residents Research Day presentations
  • Commencements videos
  • CREATE Day Occupational therapy presentations
  • Quality and Safety posters and much more
  • What People are saying about the JDC


2016 Thomas Jefferson University Commencements In The Jdc, Daniel G. Kipnis, Msi Jun 2016

2016 Thomas Jefferson University Commencements In The Jdc, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

Relive the pomp and circumstance by watching the 192nd Thomas Jefferson University commencement ceremonies in the Jefferson Digital Commons.


Barriers And Facilitators To Cervical Cancer Screening Among Iraqi Refugees Resettled In Philadelphia: A Qualitative Analysis Of Patient And Provider Perceptions, Colleen Payton, Mph, Ches, Laura Parente, Md, Dalea Al-Hawarri, Md, Philip Manasseh, Mph, Kevin Scott, Md, Marc Altshuler, Md Jun 2016

Barriers And Facilitators To Cervical Cancer Screening Among Iraqi Refugees Resettled In Philadelphia: A Qualitative Analysis Of Patient And Provider Perceptions, Colleen Payton, Mph, Ches, Laura Parente, Md, Dalea Al-Hawarri, Md, Philip Manasseh, Mph, Kevin Scott, Md, Marc Altshuler, Md

Department of Family & Community Medicine Presentations and Grand Rounds

Oral presentation at the 6th Annual North American Refugee Health Conference, Niagara Falls, New York.

Research Questions:

1. What is the prevalence of cervical cancer and cervical cancer screening among recently resettled refugees seen at Jefferson's Center for Refugee Health?

2. Are patient-and provider-identified barriers to cervical cancer screening at CRH consistent with those identified in previous research efforts?

3. What are patient-and provider identified facilitators to cervical cancer screening for Iraqi refugee women?


Using A Smartphone App To Teach Students Practical Epidemiological Skills, Russell K. Mcintire, Mph, Phd, Kathleen Day, Ms, Sean Dyer, Bs Jun 2016

Using A Smartphone App To Teach Students Practical Epidemiological Skills, Russell K. Mcintire, Mph, Phd, Kathleen Day, Ms, Sean Dyer, Bs

Thomas Jefferson University Faculty Days

Background:

Despite the evidence that shows the pedagogical benefits of experiential education, epidemiology instructors rarely utlize experiential activities to teach epidemiological concepts and skills.

Poster presented at 8th annual 2016 Thomas Jefferson University Faculty Days.


Grants Information Service, Helena Washington, Mls, Paul Hunter, Dmd, Mlis Jun 2016

Grants Information Service, Helena Washington, Mls, Paul Hunter, Dmd, Mlis

Thomas Jefferson University Faculty Days

Poster presented at 8th annual Faculty Days at Thomas Jefferson University.


Authors, Monitor Your Publications And Their Impact With Scopus And Orcid, Gary E. Kaplan, Mslis, Ahip, Patricia Wynne, Bsn, Rn, Mslis Jun 2016

Authors, Monitor Your Publications And Their Impact With Scopus And Orcid, Gary E. Kaplan, Mslis, Ahip, Patricia Wynne, Bsn, Rn, Mslis

Thomas Jefferson University Faculty Days

Poster presented at 8th annual Faculty Days at Thomas Jefferson University.


The Sustainable Development Goals: Implications And Integration Across The Curricula, Lucille B. Pilling, Mph, Edd, Rn, Kathleen C. Ashton, Phd, Rn, Acns-Bc Jun 2016

The Sustainable Development Goals: Implications And Integration Across The Curricula, Lucille B. Pilling, Mph, Edd, Rn, Kathleen C. Ashton, Phd, Rn, Acns-Bc

Thomas Jefferson University Faculty Days

Poster presented at 8th annual Faculty Days at Thomas Jefferson University.


Jdc Passes 11,000 Asset Mark, Daniel G. Kipnis, Msi Jun 2016

Jdc Passes 11,000 Asset Mark, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

The Jefferson Digital Commons now archives more than 11,000 assets and it continues to showcase Jefferson scholarship. Recent additions include: 32 conference posters and 3 newsletters.


The Structure And Regulation Of Cullin 2 Based E3 Ubiquitin Ligases And Their Biological Functions., Weijia Cai, Haifeng Yang May 2016

The Structure And Regulation Of Cullin 2 Based E3 Ubiquitin Ligases And Their Biological Functions., Weijia Cai, Haifeng Yang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and it serves as a scaffold protein for Elongin B and C, Rbx1 and various substrate recognition receptors to form E3 ubiquitin ligases.

MAIN BODY OF THE ABSTRACT: First, the composition, structure and the regulation of Cullin-2 based E3 ubiquitin ligases were introduced. Then the targets, the biological functions of complexes that use VHL, Lrr-1, Fem1b, Prame, Zyg-11, BAF250, Rack1 as substrate targeting subunits were described, and their involvement in diseases …