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Full-Text Articles in Medicine and Health Sciences
Food Quality Induces A Miscible Disease With Relevance To Alzheimer’S Disease And Neurological Diseases, Ian J. Martins
Food Quality Induces A Miscible Disease With Relevance To Alzheimer’S Disease And Neurological Diseases, Ian J. Martins
Research outputs 2014 to 2021
Food and nutrition guidelines for the handling and processing of fresh fruit, bread, and vegetables are essential and fresh produce may require cold preservation procedures to prevent minimal bacterial and fungi contamination of food. Bacterial lipopolysaccharides (LPS) corrupt lipoprotein and amyloid beta (Aβ) metabolism in diabetes, Alzheimer’s disease (AD) and various neurological diseases. In the developing world the increased plasma LPS levels induce non-alcoholic fatty liver diseases and interfere with albumin and Aβ interactions with spontaneous Aβ oligomer formation in the cerebrospinal fluid and brain that leads to neuronapoptosis by inactivation of Starling’s equation that is responsible for the maintenance …
Heat Shock Gene Sirtuin 1 Regulates Post-Prandial Lipid Metabolism With Relevance To Nutrition And Appetite Regulation In Diabetes, Ian J. Martins
Heat Shock Gene Sirtuin 1 Regulates Post-Prandial Lipid Metabolism With Relevance To Nutrition And Appetite Regulation In Diabetes, Ian J. Martins
Research outputs 2014 to 2021
New discoveries in medicine are required to understand the importance of appetite regulation that is associated with the overconsumption of foodin Type 2 and Type 3 diabetes. Food restriction in diabetes is essential to maintain the hepatic metabolism of dietary fat with relevance to defective post-prandial lipid metabolism and to the global non alcoholic fatty liver disease (NAFLD) epidemic [1,2]. Premature brain aging has become important with the development of Type 3 diabetesand Alzheimer’s disease [3] that is associated with repression of the anti-aging gene Sirtuin 1 (Sirt 1) relevant topost-prandial lipid metabolism, amyloid beta metabolism (peptide involved in amyloid …
Bacterial Lipopolysaccharides Change Membrane Fluidity With Relevance To Phospholipid And Amyloid Beta Dynamics In Alzheimer's Disease, Ian James Martins
Bacterial Lipopolysaccharides Change Membrane Fluidity With Relevance To Phospholipid And Amyloid Beta Dynamics In Alzheimer's Disease, Ian James Martins
Research outputs 2014 to 2021
Bacterial lipopolysaccharides (LPS) and their increase in plasma in individuals in the developing world has become of major concern. LPS can transform cells by their rapid insertion into cell membranes that partition into cholesterol/sphingomyelin domains. LPS alter cell phospholipid dynamics associated with the recruitment of the Alzheimer’s disease amyloid beta (Aβ) peptide with the promotion of toxic Aβ oligomer formation. The common pattern of naturally occurring phospholipids such as1-palmitoyl-2-oleolyl-phosphatidylcholine in cells confers cells with the rapid transfer of Aβ and phospholipids. Phospholipids such as dipalmitoylphosphatidylcholine (DPPC), dimyristoylphosphatidylcholine (DMPC) and dioleoylphosphatidylcholine (DOPC) are poorly transported with delayed metabolism of Aβ oligomers. …
Food Intake And Caffeine Determine Amyloid Beta Metabolism With Relevance To Mitophagy In Brain Aging And Chronic Disease, Ian J. Martins
Food Intake And Caffeine Determine Amyloid Beta Metabolism With Relevance To Mitophagy In Brain Aging And Chronic Disease, Ian J. Martins
Research outputs 2014 to 2021
In the global world diabetes and mitochondrial disease is expected to cost the developing world in the next 30 years US $400 million. In diabetes an absent peripheral sink amyloid beta clearance pathway is now relevant to amyloid beta induced mitochondrial apoptosis. The quality of food consumed has raised major concerns with increased levels of plasma bacterial lipopolysaccharides (LPS) that induces amyloid beta aggregation and mitochondrial apoptosis with programmed cell death linked to non alcoholic fatty liver disease (NAFLD) and many organ diseases. The amount, nature and time of day of fat consumption in diabetes has become important with relevance …
Magnesium Therapy Prevents Senescence With The Reversal Of Diabetes And Alzheimer’S Disease, Ian James Martins
Magnesium Therapy Prevents Senescence With The Reversal Of Diabetes And Alzheimer’S Disease, Ian James Martins
Research outputs 2014 to 2021
In the current global epidemic for Non Alcoholic Fatty Liver Disease (NAFLD), diabetes and neurodegenerative diseases such as Alzheimer’s disease there has been a major interest in magnesium therapy to delay the severity of NAFLD, Type 3 diabetes and neurodegeneration in the developing and developed world. The objective of magnesium therapy is to activate the anti-aging gene Sirtuin 1 (Sirt1) to prevent cardiovascular disease, NAFLD and diabetes. Reduced consumption of nutrients such as fatty acids, glucose, cholesterol and increased magnesium consumption is closely linked to reduced bacterial lipopolysaccharides (LPS) and activation of Sirt1 relevant to active nuclear and mitochondria interactions …