Medicine and Health Sciences Commons^™

Oxidative Stress Induces Transient O‐Glcnac Elevation And Tau Dephosphorylation In Sh‐Sy5y Cells, Emese Katai, Jozsef Pal, Viktor Soma Poor, Rupeena Purewal, Attila Miseta, Tamas Nagy

Faculty & Staff Scholarship

O‐linked β‐N‐acetlyglucosamine or O‐GlcNAc modification is a dynamic post‐translational modification occurring on the Ser/Thr residues of many intracellular proteins. The chronic imbalance between phosphorylation and O‐GlcNAc on tau protein is considered as one of the main hallmarks of Alzheimer's disease. In recent years, many studies also showed that O‐GlcNAc levels can elevate upon acute stress and suggested that this might facilitate cell survival. However, many consider chronic stress, including oxidative damage as a major risk factor in the development of the disease. In this study, using the neuronal cell line SH‐SY5Y we investigated the dynamic nature of O‐GlcNAc …

Gender Differences In Murine Pulmonary Responses Elicited By Cellulose Nanocrystals, Anna A. Shvedova, Elena R. Kisin, Naveena Yanamala, Mariana T. Farcas, Autumn L. Menas, Andrew Williams, Philip M. Fournier, Jeffrey S. Reynolds, Dmitriy W. Gutkin, Alexander Star, Richard S. Reiner, Sabina Halappanavar, Valerian E. Kagan

Faculty & Staff Scholarship

Background: Cellulose-based materials have been used for centuries to manufacture different goods derived from forestry and agricultural sources. In the growing field of nanocellulose applications, its uniquely engineered properties are instrumental for inventive products coming to competitive markets. Due to their high aspect ratio and stiffness, it is speculated that cellulose nanocrystals (CNC) may cause similar pulmonary toxicity as carbon nanotubes and asbestos, thus posing a potential negative impact on public health and the environment.

Methods: The present study was undertaken to investigate the pulmonary outcomes induced by repeated exposure to respirable CNC. C57BL/6 female and male mice were exposed …