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Full-Text Articles in Medicine and Health Sciences
Anti-Aging Genes Improve Appetite Regulation And Reverse Cell Senescence And Apoptosis In Global Populations, Ian James Martins
Anti-Aging Genes Improve Appetite Regulation And Reverse Cell Senescence And Apoptosis In Global Populations, Ian James Martins
Research outputs 2014 to 2021
Appetite regulation by nutritional intervention is required early in life that involves the anti-aging gene Sirtuin 1 (Sirt 1) with Sirt 1 maintenance of other cellular anti-aging genes involved in cell circadian rhythm, senescence and apoptosis. Interests in anti-aging therapy with appetite regulation improve an individual’s survival to metabolic disease induced by gene-environment interactions by maintenance of the anti-aging genes connected to the metabolism of bacterial lipopolysaccharides, drugs and xenobiotics. Interventions to the aging process involve early calorie restriction with appetite regulation connected to appropriate genetic mechanisms that involve mitochondrial biogenesis and DNA repair in neurons. In the aging process …
Drug Therapy For Obesity With Anti-Aging Genes Modification, Ian J. Martins
Drug Therapy For Obesity With Anti-Aging Genes Modification, Ian J. Martins
Research outputs 2014 to 2021
Nutritional regulation and drug therapy has been the focus of the current obesity epidemic in various countries in the world. Epigenetics is the major mechanism for the development of insulin resistance and obesity with unhealthy diets, oxidative stress and environmental factors relevant to alterations in gene expression with effects on mitochondrial biogenesis, adipose tissue lipid metabolism and energy expenditure. Anti-aging genes are involved in the regulation of adipogenesis with increased sensitivity to anti-aging gene dysfunction associated with adipocyte-neuron interactions compared to other cells. Unhealthy diets downregulate adipocyte anti-aging genes associated with the development of Non Alcoholic Fatty Liver Disease (NAFLD) …
Heat Shock Gene Sirtuin 1 Regulates Post-Prandial Lipid Metabolism With Relevance To Nutrition And Appetite Regulation In Diabetes, Ian J. Martins
Heat Shock Gene Sirtuin 1 Regulates Post-Prandial Lipid Metabolism With Relevance To Nutrition And Appetite Regulation In Diabetes, Ian J. Martins
Research outputs 2014 to 2021
New discoveries in medicine are required to understand the importance of appetite regulation that is associated with the overconsumption of foodin Type 2 and Type 3 diabetes. Food restriction in diabetes is essential to maintain the hepatic metabolism of dietary fat with relevance to defective post-prandial lipid metabolism and to the global non alcoholic fatty liver disease (NAFLD) epidemic [1,2]. Premature brain aging has become important with the development of Type 3 diabetesand Alzheimer’s disease [3] that is associated with repression of the anti-aging gene Sirtuin 1 (Sirt 1) relevant topost-prandial lipid metabolism, amyloid beta metabolism (peptide involved in amyloid …