Medicine and Health Sciences Commons^™

Optical Coherence Photoacoustic Microscopy (Oc-Pam) For Multimodal Imaging, Xiaojing Liu

FIU Electronic Theses and Dissertations

Optical coherence tomography (OCT) and Photoacoustic microscopy (PAM) are two noninvasive, high-resolution, three-dimensional, biomedical imaging modalities based on different contrast mechanisms. OCT detects the light backscattered from a biological sample either in the time or spectral domain using an interferometer to form an image. PAM is sensitive to optical absorption by detecting the light-induced acoustic waves to form an image. Due to their complementary contrast mechanisms, OCT and PAM are suitable for being combined to achieve multimodal imaging.

In this dissertation, an optical coherence photoacoustic microscopy (OC-PAM) system was developed for in vivo multimodal retinal imaging with a pulsed broadband …

Review Of Fluorescence Guided Surgery Systems: Identification Of Key Performance Capabilities Beyond Indocyanine Green Imaging, Alisha V. Dsouza, Huiyun Lin, Eric R. Henderson, Kimberley S. Samkoe

Dartmouth Scholarship

There is growing interest in using fluorescence imaging instruments to guide surgery, and the leading options for open-field imaging are reviewed here. While the clinical fluorescence-guided surgery (FGS) field has been focused predominantly on indocyanine green (ICG) imaging, there is accelerated development of more specific molecular tracers. These agents should help advance new indications for which FGS presents a paradigm shift in how molecular information is provided for resection decisions. There has been a steady growth in commercially marketed FGS systems, each with their own differentiated performance characteristics and specifications. A set of desirable criteria is presented to guide the …