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Full-Text Articles in Medicine and Health Sciences
Exploring Egr-1 As A Master Regulator Of Prostate Field Cancerization, Kristin Gabriel, Marco Bisoffi
Exploring Egr-1 As A Master Regulator Of Prostate Field Cancerization, Kristin Gabriel, Marco Bisoffi
Student Scholar Symposium Abstracts and Posters
Field cancerization denotes the presence of molecular aberrations (genetic, epigenetic, biochemical) in structurally intact cells residing in histologically normal tissues adjacent to tumors. Markers of field cancerization in prostate tissues have the potential to improve the clinical management of this malignancy through their potential to act as indicators of early disease and to serve as molecular targets for early intervention. However, for this, a detailed understanding of the functional pathways underlying field cancerization is necessary. We have recently identified four protein markers of prostate field cancerization, i.e. the key transcription factor early growth response 1 (EGR-1), the lipogenic enzyme fatty …
Effect Of Curcumin Analog Ca27 On Androgen Receptor Translocation In Prostate Cancer Cells, Lijah Vann Gardner
Effect Of Curcumin Analog Ca27 On Androgen Receptor Translocation In Prostate Cancer Cells, Lijah Vann Gardner
Student Scholar Symposium Abstracts and Posters
The androgen receptor (AR) plays an essential role in promoting the development and progression of metastatic prostate cancer and represents an important molecular target for therapeutic intervention. We have recently described a series of synthetic analogs of the natural product diferuloylmethane (curcumin), some of which induce the down-regulation of AR expression in prostate cancer cells by an as yet largely unknown mechanism of action. While such analogs may in the long term be lead structures for the development of therapeutic drugs, we hypothesize here that they represent ideal molecular probes to identify the mechanism(s) of action for AR down-regulation. We …