Medicine and Health Sciences Commons^™

Initial Validation Of A Novel Method Of Presurgical Language Localization Through Functional Connectivity (Fcmri), Stephanie M. Noble, Dustin Scheinost, Susan Y. Bookheimer, Patricia Walshaw, R Todd Constable, Christopher F. Benjamin

Yale Day of Data

OBJECTIVE: Neurosurgery is potentially curative in chronic epilepsy but can only be offered to patients if the surgical risk to language is known. Clinical functional magnetic resonance imaging (fMRI) is an ideal, noninvasive method for localizing language cortex yet remains to be validated for this purpose. We have recently presented a novel method for localizing language cortex. Here we present a preliminary evaluation of this method’s validity. We hypothesized language regions identified using this novel method would demonstrate stronger functional connectivity than randomly generated set of proximal networks. METHOD: fMRI data were collected from sixteen temporal lobe patients …

A Neurovascular Decoupling During Ictal Activity In Rats With Focal Epilepsy, Rafael Torres

Undergraduate Research at FIU (URFIU) Conference

The spatiotemporal profiles of neuronal activity, hemodynamics and metabolic rate in epileptic cortices during focal ictal activity were recently evaluated using modern imaging techniques in acute situations (4-aminopyridine). However, no studies have verified these profiles in chronic models of focal epilepsy. In this study, we combined electrophysiology and optical techniques to untangle the relationships between neuronal activities and hemodynamic responses during ictal periods in the cortices of rats with chronic focal epilepsy.

13 Wistar rats with focal epilepsy were used in this study. Candidate regions for a craniotomy were obtained from EEG source imaging and BOLD effect associated with interictal …