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Is There An Ideal Level Of Platelet P2y12-Receptor Inhibition In Patients Undergoing Percutaneous Coronary Intervention?: "Window" Analysis From The Adapt-Des Study (Assessment Of Dual Antiplatelet Therapy With Drug-Eluting Stents)., Ajay J. Kirtane Md, Puja B. Parikh Md, Thomas D. Stuckey Md, Ke Xu Phd, Bernhard Witzenbichler Md, Giora Weisz Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Bruce R. Brodie Md, Ernest L. Mazzaferri Md, Rupa Parvataneni Ms, Akiko Maehara Md, Philippe Généreux Md, Roxana Mehran Md, Gregg W. Stone Md Dec 2015

Is There An Ideal Level Of Platelet P2y12-Receptor Inhibition In Patients Undergoing Percutaneous Coronary Intervention?: "Window" Analysis From The Adapt-Des Study (Assessment Of Dual Antiplatelet Therapy With Drug-Eluting Stents)., Ajay J. Kirtane Md, Puja B. Parikh Md, Thomas D. Stuckey Md, Ke Xu Phd, Bernhard Witzenbichler Md, Giora Weisz Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Bruce R. Brodie Md, Ernest L. Mazzaferri Md, Rupa Parvataneni Ms, Akiko Maehara Md, Philippe Généreux Md, Roxana Mehran Md, Gregg W. Stone Md

Department of Medicine

OBJECTIVES: This study sought to determine whether there is an ideal level of platelet reactivity (PR) to optimize safety and efficacy within the large multicenter ADAPT-DES (Assessment of Dual AntiPlatelet Therapy With Drug-Eluting Stents) study of 8,582 patients receiving successful drug-eluting stent implantation.

BACKGROUND: Patients with high PR on clopidogrel have a greater incidence of adverse ischemic events after stent implantation, whereas low PR may increase bleeding. Due to limited sample size, previous studies have not been able to adjust for differences in baseline characteristics that may confound the relationship of PR and outcomes.

METHODS: In the ADAPT-DES study, routine …


Dust Off Huffing: Emerging As A New And Cheap Form Of Abuse And A Cause Of Different Types Of Arrhythmias With Transient Multiorgan Failure, Deepika Jain Md, Raman Dusaj Md Nov 2015

Dust Off Huffing: Emerging As A New And Cheap Form Of Abuse And A Cause Of Different Types Of Arrhythmias With Transient Multiorgan Failure, Deepika Jain Md, Raman Dusaj Md

Department of Medicine

No abstract provided.


Making The Case: Data Collection Made Easy, Jennifer Allen Md, Daniel Ray Md, Daniel Ray Md, R Schira Nov 2015

Making The Case: Data Collection Made Easy, Jennifer Allen Md, Daniel Ray Md, Daniel Ray Md, R Schira

Department of Medicine

No abstract provided.


Prognostic Significance Of Tissue Oxygen Saturation Using Near Infrared Spectroscopy In Patients Undergoing Therapeutic Hypothermia After Cardiac Arrest, Adrian C. Bell Do, Ataul Qureshi Md, Stephen Awuor Md, Sanjeev U. Nair Md, Agei Enoh Md, Daniel J. Makowski Do, Charity Curtis Mph, Nainesh Patel Md, Facc, Bruce Feldman Do, Facc Nov 2015

Prognostic Significance Of Tissue Oxygen Saturation Using Near Infrared Spectroscopy In Patients Undergoing Therapeutic Hypothermia After Cardiac Arrest, Adrian C. Bell Do, Ataul Qureshi Md, Stephen Awuor Md, Sanjeev U. Nair Md, Agei Enoh Md, Daniel J. Makowski Do, Charity Curtis Mph, Nainesh Patel Md, Facc, Bruce Feldman Do, Facc

Department of Medicine

No abstract provided.


Outcomes In Patients With Persistent Dialysis-Dependent Acute Kidney Injury, Aedan Olaso Md, Daniel Tseytlin Do, Hope Kincaid Mph, Cph, Sharon E. Maynard Md Nov 2015

Outcomes In Patients With Persistent Dialysis-Dependent Acute Kidney Injury, Aedan Olaso Md, Daniel Tseytlin Do, Hope Kincaid Mph, Cph, Sharon E. Maynard Md

Department of Medicine

No abstract provided.


Sotatercept Improves Anemia, Vascular Calcification, And Bone Loss In Patients With End-Stage Kidney Disease On Hemodialysis, John Havill, Nelson Kopyt Do, Fasn, Facp, Daniel Coyne, Michael Weiswasser, William T. Smith Nov 2015

Sotatercept Improves Anemia, Vascular Calcification, And Bone Loss In Patients With End-Stage Kidney Disease On Hemodialysis, John Havill, Nelson Kopyt Do, Fasn, Facp, Daniel Coyne, Michael Weiswasser, William T. Smith

Department of Medicine

No abstract provided.


A Descriptive Study Of Pulmonary Function Testing And Chest Computed Tomography In Survivors Of Veno-Venous Extracorporeal Membrane Oxygenation, Matthew Miles Do, Dorothea T. Watson Do, Rita Pechulis Md, Fccp Oct 2015

A Descriptive Study Of Pulmonary Function Testing And Chest Computed Tomography In Survivors Of Veno-Venous Extracorporeal Membrane Oxygenation, Matthew Miles Do, Dorothea T. Watson Do, Rita Pechulis Md, Fccp

Department of Medicine

No abstract provided.


Retained Medical Knowledge In Cardiopulmonary Resuscitation Affected By Simulated Mock Code Blue Session, Rachel Lipner Do, Katie Mastoris Do, Matthew Miles Do, Sarah Park Do, Ryan Rogers Do, Stacey Smith Md, Facp, Miranda Haslam Oct 2015

Retained Medical Knowledge In Cardiopulmonary Resuscitation Affected By Simulated Mock Code Blue Session, Rachel Lipner Do, Katie Mastoris Do, Matthew Miles Do, Sarah Park Do, Ryan Rogers Do, Stacey Smith Md, Facp, Miranda Haslam

Department of Medicine

No abstract provided.


Improving Pneumococcal Vaccination Rates Using Exclusive Clinic Visits; A Pilot Program, Ronald R. Julia Md, Ms, Michael J. Sither Do, Mph, Cheryl A. Bloomfield Md Oct 2015

Improving Pneumococcal Vaccination Rates Using Exclusive Clinic Visits; A Pilot Program, Ronald R. Julia Md, Ms, Michael J. Sither Do, Mph, Cheryl A. Bloomfield Md

Department of Medicine

No abstract provided.


A Very Rare Etiology Of Deep Vein Thrombosis ‘Kilt Syndrome’, Arsha Sreedhar Md, Ranjit R. Nair Md, Mohammad Saqib Md Oct 2015

A Very Rare Etiology Of Deep Vein Thrombosis ‘Kilt Syndrome’, Arsha Sreedhar Md, Ranjit R. Nair Md, Mohammad Saqib Md

Department of Medicine

No abstract provided.


Recognizing Miller Fisher Syndrome, Samer Bolis Do, Stacey Smith Md Oct 2015

Recognizing Miller Fisher Syndrome, Samer Bolis Do, Stacey Smith Md

Department of Medicine

No abstract provided.


Gi Bleed With Pancytopenia - A Rare Case Of Aml Subtype Acute Panmyelosis With Mylefibrosis (Apmf), Dhwani Pandya Md, Philip Dunn Do, Stacey Smith Md, Facp Oct 2015

Gi Bleed With Pancytopenia - A Rare Case Of Aml Subtype Acute Panmyelosis With Mylefibrosis (Apmf), Dhwani Pandya Md, Philip Dunn Do, Stacey Smith Md, Facp

Department of Medicine

No abstract provided.


Neurofibromatosis Type 1 With Ampullary Somatostatinoma, Small Bowel Gists, And Extra-Adrenal Composite Pheochromocytoma-Ganglioneuroma, Patrick Hickey Do, Rohit Sharma Md, Shanth A. Goonewardene Md, Shashin Shah Md, Hiral N. Shah Md Oct 2015

Neurofibromatosis Type 1 With Ampullary Somatostatinoma, Small Bowel Gists, And Extra-Adrenal Composite Pheochromocytoma-Ganglioneuroma, Patrick Hickey Do, Rohit Sharma Md, Shanth A. Goonewardene Md, Shashin Shah Md, Hiral N. Shah Md

Department of Medicine

No abstract provided.


Low Cea Cystic Pancreatic Tumors, A Tail Of Two Cysts, Patrick Hickey Do, Hiral N. Shah Md, Shashin Shah Md Oct 2015

Low Cea Cystic Pancreatic Tumors, A Tail Of Two Cysts, Patrick Hickey Do, Hiral N. Shah Md, Shashin Shah Md

Department of Medicine

No abstract provided.


In The Groove: A Case Series Of Groove Pancreatitis, Matthew Sullivan Do, Jeffrey Brodsky Md, Shashin Shah Md, Hiral N. Shah Md Oct 2015

In The Groove: A Case Series Of Groove Pancreatitis, Matthew Sullivan Do, Jeffrey Brodsky Md, Shashin Shah Md, Hiral N. Shah Md

Department of Medicine

No abstract provided.


Attempted Salvage Therapy Through Initiation Of Vedolizumab As An Inpatient In Two Patients With Refractory Active Ulcerative Colitis, Matthew Sullivan Do, Paola Blanco Md, Shashin Shah Md, Hiral N. Shah Md Oct 2015

Attempted Salvage Therapy Through Initiation Of Vedolizumab As An Inpatient In Two Patients With Refractory Active Ulcerative Colitis, Matthew Sullivan Do, Paola Blanco Md, Shashin Shah Md, Hiral N. Shah Md

Department of Medicine

No abstract provided.


Pancreatitis Associated With Ttp: A Cause Or Effect?, Shannon Davis Do, Ranjit R. Nair Md, Nicole M. Agostino Do Oct 2015

Pancreatitis Associated With Ttp: A Cause Or Effect?, Shannon Davis Do, Ranjit R. Nair Md, Nicole M. Agostino Do

Department of Medicine

No abstract provided.


Tct- 597 Two-Year Ischemic And Bleeding Outcomes After Coronary Intervention Of Calcified Vs. Non-Calcified Lesion Treated With Drug-Eluting Stents: The Adapt Des Study, Philippe Généreux Md, Guillaume Marquis Gravel, Bernhard Witzenbichler Md, Giora Weisz Md, Thomas D. Stuckey Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest L. Mazzaferri Md, Girish B. Ramteke, Claire Litherland Ms, Ajay J. Kirtane Md, Roxana Mehran Md, Gregg W. Stone Md Oct 2015

Tct- 597 Two-Year Ischemic And Bleeding Outcomes After Coronary Intervention Of Calcified Vs. Non-Calcified Lesion Treated With Drug-Eluting Stents: The Adapt Des Study, Philippe Généreux Md, Guillaume Marquis Gravel, Bernhard Witzenbichler Md, Giora Weisz Md, Thomas D. Stuckey Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest L. Mazzaferri Md, Girish B. Ramteke, Claire Litherland Ms, Ajay J. Kirtane Md, Roxana Mehran Md, Gregg W. Stone Md

Department of Medicine

No abstract provided.


Tct-64 Incidence, Predictors, And Impact Of Post-Discharge Bleeding Compared To Myocardial Infarction After Percutaneous Coronary Intervention, Philippe Généreux Md, Gennaro Giustino Md, Bernhard Witzenbichler Md, Giora Weisz Md, Thomas D. Stuckey Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest L. Mazzaferri Md, Mayank Yadav, Ajay J. Kirtane Md, Claire Litherland Ms, Roxana Mehran Md, Gregg W. Stone Md Oct 2015

Tct-64 Incidence, Predictors, And Impact Of Post-Discharge Bleeding Compared To Myocardial Infarction After Percutaneous Coronary Intervention, Philippe Généreux Md, Gennaro Giustino Md, Bernhard Witzenbichler Md, Giora Weisz Md, Thomas D. Stuckey Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest L. Mazzaferri Md, Mayank Yadav, Ajay J. Kirtane Md, Claire Litherland Ms, Roxana Mehran Md, Gregg W. Stone Md

Department of Medicine

No abstract provided.


Microlymphoma, A Rare Clinicopathologic Entity During The Evolution Of An Aggressive Lymphoma: A Case Report, Andrew Heisel Ms4, Arsha Sreedhar Md, Nicholas Lamparella Do, Ranjit R. Nair Md, Shereen M. Gheith Md, Phd Sep 2015

Microlymphoma, A Rare Clinicopathologic Entity During The Evolution Of An Aggressive Lymphoma: A Case Report, Andrew Heisel Ms4, Arsha Sreedhar Md, Nicholas Lamparella Do, Ranjit R. Nair Md, Shereen M. Gheith Md, Phd

Department of Medicine

No abstract provided.


Trans-Catheter Aortic Valve Replacement: The Future Is Here, Raymond Singer, J Kleaveland Sep 2015

Trans-Catheter Aortic Valve Replacement: The Future Is Here, Raymond Singer, J Kleaveland

Raymond L Singer MD

No abstract provided.


Incidence, Predictors And Impact Of Post-Discharge Bleeding After Percutaneous Coronary Intervention., Philippe Généreux Md, Gennaro Giustino Md, Bernhard Witzenbichler Md, Giora Weisz Md, Thomas D. Stuckey Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest Mazzaferri Md, Mayank Yadav, Dominic P. Francese Mph, Tullio Palmerini, Ajay J. Kirtane Md, Claire Litherland Ms, Roxana Mehran Md, Gregg W. Stone Md Sep 2015

Incidence, Predictors And Impact Of Post-Discharge Bleeding After Percutaneous Coronary Intervention., Philippe Généreux Md, Gennaro Giustino Md, Bernhard Witzenbichler Md, Giora Weisz Md, Thomas D. Stuckey Md, Michael J. Rinaldi Md, Franz-Josef Neumann Md, D Christopher Metzger Md, Timothy D. Henry Md, David A. Cox Md, Peter L. Duffy Md, Ernest Mazzaferri Md, Mayank Yadav, Dominic P. Francese Mph, Tullio Palmerini, Ajay J. Kirtane Md, Claire Litherland Ms, Roxana Mehran Md, Gregg W. Stone Md

Department of Medicine

BACKGROUND: The incidence, predictors, and prognostic impact of post-discharge bleeding (PDB) after percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation are unclear.

OBJECTIVES: This study sought to characterize the determinants and consequences of PDB after PCI.

METHODS: The prospective ADAPT-DES (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) study was used to determine the incidence and predictors of clinically relevant bleeding events occurring within 2 years after hospital discharge. The effect of PDB on subsequent 2-year all-cause mortality was estimated by time-adjusted Cox proportional hazards regression.

RESULTS: Among 8,582 "all-comers" who underwent successful PCI with DES in the ADAPT-DES …


Outcomes Of Comatose Cardiac Arrest Survivors With And Without St-Segment Elevation Myocardial Infarction: Importance Of Coronary Angiography., Karl B Kern, Kapildeo Lotun, Nainesh Patel, Michael R Mooney, Ryan D Hollenbeck, John A Mcpherson, Paul W Mcmullan, Barbara Unger, Chiu-Hsieh Hsu, David B Seder Aug 2015

Outcomes Of Comatose Cardiac Arrest Survivors With And Without St-Segment Elevation Myocardial Infarction: Importance Of Coronary Angiography., Karl B Kern, Kapildeo Lotun, Nainesh Patel, Michael R Mooney, Ryan D Hollenbeck, John A Mcpherson, Paul W Mcmullan, Barbara Unger, Chiu-Hsieh Hsu, David B Seder

Nainesh C Patel MD

OBJECTIVES: The aim of this study was to compare outcomes and coronary angiographic findings in post-cardiac arrest patients with and without ST-segment elevation myocardial infarction (STEMI). BACKGROUND: The 2013 STEMI guidelines recommend performing immediate angiography in resuscitated patients whose initial electrocardiogram shows STEMI. The optimal approach for those without STEMI post-cardiac arrest is less clear. METHODS: A retrospective evaluation of a post-cardiac arrest registry was performed. RESULTS: The database consisted of 746 comatose post-cardiac arrest patients including 198 with STEMI (26.5%) and 548 without STEMI (73.5%). Overall survival was greater in those with STEMI compared with those without (55.1% vs. …


Medical Hypothermia Post Cardiac Arrest, Nainesh Patel, John Castaldo, Ronald Freudenberger, Sudip Nanda Aug 2015

Medical Hypothermia Post Cardiac Arrest, Nainesh Patel, John Castaldo, Ronald Freudenberger, Sudip Nanda

Nainesh C Patel MD

No abstract provided.


Risk Of Heart Failure And Death After Prolonged Smoking Cessation: Role Of Amount And Duration Of Prior Smoking., Amiya A Ahmed, Kanan Patel, Margaret A Nyaku, Raya E Kheirbek, Vera Bittner, Gregg C Fonarow, Gerasimos S Filippatos, Charity J Morgan, Inmaculada Aban, Marjan Mujib, Ravi Desai, Richard M Allman, Michel White, Prakash Deedwania, George Howard, Robert O Bonow, Ross D Fletcher, Wilbert S Aronow, Ali Ahmed Aug 2015

Risk Of Heart Failure And Death After Prolonged Smoking Cessation: Role Of Amount And Duration Of Prior Smoking., Amiya A Ahmed, Kanan Patel, Margaret A Nyaku, Raya E Kheirbek, Vera Bittner, Gregg C Fonarow, Gerasimos S Filippatos, Charity J Morgan, Inmaculada Aban, Marjan Mujib, Ravi Desai, Richard M Allman, Michel White, Prakash Deedwania, George Howard, Robert O Bonow, Ross D Fletcher, Wilbert S Aronow, Ali Ahmed

Ravi V Desai MD

BACKGROUND: -According to the 2004 Surgeon General's Report on Health Consequences of Smoking, after >15 years of abstinence, the cardiovascular risk of former smokers becomes similar to that of never-smokers. Whether this health benefit of smoking cessation varies by amount and duration of prior smoking remains unclear.

METHODS AND RESULTS: -Of the 4482 adults ≥65 years without prevalent heart failure (HF) in the Cardiovascular Health Study (CHS), 2556 were never-smokers, 629 current smokers, and 1297 former smokers with >15 years of cessation, of whom 312 were heavy smokers (highest quartile; ≥32 pack-years). Age-sex-race-adjusted hazard ratios (aHR) and 95% confidence intervals …


Ectopic Cushing Syndrome And Pancreatic Cancer: A Case Report, Mira Mitry Md, Nicole M. Agostino Do, Stacey Smith Md, Facp, Vasudev G. Magaji Md, Ms Aug 2015

Ectopic Cushing Syndrome And Pancreatic Cancer: A Case Report, Mira Mitry Md, Nicole M. Agostino Do, Stacey Smith Md, Facp, Vasudev G. Magaji Md, Ms

Vasudev G Magaji MD, MS

No abstract provided.


Mifepristone Utilization In Cushing’S From Large Bilateral Adrenal Adenoma Prior To Surgery, Vasudev Magaji, Sarah Park, Katie Mastoris, Maura Bucciarelli, Scott Beman Aug 2015

Mifepristone Utilization In Cushing’S From Large Bilateral Adrenal Adenoma Prior To Surgery, Vasudev Magaji, Sarah Park, Katie Mastoris, Maura Bucciarelli, Scott Beman

Vasudev G Magaji MD, MS

Utilization of mifepristone was described to mitigate hypercortisolism from bilateral adrenal Cushing’s syndrome. A 47-year-old female on abdominal pain evaluation with CT was found to have a 5.4 × 1.7 × 4.9 cm right adrenal nodule and a 4.3 × 2.9 × 3.3 cm left adrenal nodule with calcification on CT scan with each having density of -3 Housefield units. She had hypercortisolism with testing revealing high urine free cortisol, unsuppressed cortisol on 1 mg and 8 mg overnight dexamethasone suppression testing, high 11 pm salivary cortisol × 2 along with elevated random cortisol and undetectable ACTH. Her DHEA-S, plasma …


Use Of An Electronic Medical Record (Emr) To Identify Glycemic Intensification Strategies In Type 2 Diabetes., Mary T Korytkowski, Maria Brooks, Manuel Lombardero, Dilhari Dealmeida, Justin Kanter, Vasudev Magaji, Trevor Orchard, Linda Siminerio Aug 2015

Use Of An Electronic Medical Record (Emr) To Identify Glycemic Intensification Strategies In Type 2 Diabetes., Mary T Korytkowski, Maria Brooks, Manuel Lombardero, Dilhari Dealmeida, Justin Kanter, Vasudev Magaji, Trevor Orchard, Linda Siminerio

Vasudev G Magaji MD, MS

Current treatment guidelines for type 2 diabetes (T2D) recommend individualized intensification of therapy for glycated hemoglobin (A1C) ≥ 7% in most patients. The purpose of this investigation was to explore the ability of an electronic medical record (EMR) to identify glycemic intensification strategies among T2D patients receiving pharmacologic therapy. Patient records between 2005 and 2011 with documentation of A1C and active prescriptions for any diabetes medications were queried to identify potential candidates for intensification based on A1C ≥ 7% while on 1-2 oral diabetes medications (ODM). Patients with follow-up A1C values within 1 year of index A1C were grouped according …


1,25-Dihydroxyvitamin D-Mediated Hypercalcemia In A Patient With Maligancy Without Lymphoma, Katie Mastoris, Sarah Park, Vasudev Magaji Aug 2015

1,25-Dihydroxyvitamin D-Mediated Hypercalcemia In A Patient With Maligancy Without Lymphoma, Katie Mastoris, Sarah Park, Vasudev Magaji

Vasudev G Magaji MD, MS

No abstract provided.


Ectopic Acth Syndrome Due To Men-I Associated Metastatic Neuroendocrine Pancreatic Gastrinoma In A 22 Year Old Female Without Hyperparathyroidism: Diagnostic And Therapeutic Challenges, Vasudev Magaji, Mansoor Tanwir, Mary Korytkowski, Sue Challinor Aug 2015

Ectopic Acth Syndrome Due To Men-I Associated Metastatic Neuroendocrine Pancreatic Gastrinoma In A 22 Year Old Female Without Hyperparathyroidism: Diagnostic And Therapeutic Challenges, Vasudev Magaji, Mansoor Tanwir, Mary Korytkowski, Sue Challinor

Vasudev G Magaji MD, MS

Introduction: Ectopic ACTH production due to malignant tumors is a rare cause of Cushing's syndrome (CS). Diagnosis and treatment of such patients can be challenging. Case: 22 year old female with recent onset fatigue, weight gain, polyuria, polydipsia, presented with melena and hypotension. She had cushingoid facies, acne, central obesity, muscle weakness and purple striae. Labs showed: Cortisol 56 µg/dl (5-15), 24 hour UFC >1000 µg/24hr (5-50), Cortisol after 1mg Dexamethasone suppression 54 µg/dl (Learning points: When evaluating patients with suspected ectopic ACTH production, independent review of radiologic imaging should be done to avoid being misled by prior reports. EUS …